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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | Synthesis and antibacterial evaluation of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives显示文摘Objective:To synthesis 2-substituted-4,5-diphenyl-N- alkyl imidazole derivatives,and evaluate their antibacterial activity.Methods:A mixture of benzil(10 mmol) and ammonium acetate(0.1 mol)(immediately fused) in glacial acetic acid(25 mL) was stirred at 80-100℃for 1 h under nitrogen atmosphere(to prevent incorporation of any atmospheric impurities and moisture). Substituted aldehydes(10 mmol) in glacial acetic acid(5 mL) was added drop-wise over a period of 15-20 min at the same temperature and stirred for another 4 h,the progress of the reaction was monitored by TLC test using ethyl acetate as eluent.The newly synthesized compounds were characterized by IR,1HNMR,13CNMR and by mass spectroscopy.Results:All the synthesized compounds were confirmed by spectroscopical techniques and evaluated for antimicrobial activity against Staphylococcus aureus(S.aurius),Bacilus subtilus(B.subtilus),and Escheria coli (E.coli).These compounds showed antibacterial activity(zone of inhibition) against S.aurius ranged from 3 mm to 9 mmin diameter,B.subtilus,4 -8 mm,and E.coli 5 -12 mm.Out of 2a-2e, only 2a and 2b showed some sort of activity but none of them had considerable activity compared with that of the standard.Conclusions:All the synthesized compounds show moderate activity against the tested bacteria S.aurius,B.subtilus,and E.coli.So,further structural modification is necessary to improve the antibacterial action of 2-substituted-4,5-diphenyl-N-alkyl imidazole derivatives. | Abhishek K Jain V Ravichandran Madhvi Sisodiya RK Agrawal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 3 |
| 3 | Laparoscopic pyeloplasty:our new gold standard显示文摘 | Symons SJ Bhirud PS Jain V | 2009 | Journal of Endocrinology2009，，03： | 2 |
| 4 | Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation 显示文摘 | SAMANTA S K SINGH O V JAIN R K | 2002 | Trends Biotechnol2002，20，6： | 1 |
| 5 | Melatonin loaded ethanolie liposomes: Physico- chemical characterization and enhanced transdermal delivery 显示文摘 | Dubey V Mishra D Jain NK | 2007 | European Journal of Pharmaceutics atut Biopharmaceutics2007，67，： | 1 |
| 6 | Parallel EFG algorithm for heat transfer problems 显示文摘 | Singh I V Jain P K | 2005 | Advances in Engineering Software2005，36，8： | 1 |
| 7 | Time and pH Dependent Colon Specific, Pulsatile Delivery of Theophylline for Nocturnal Asthma显示文摘 | Mastiholimath V S Dandagi P M Samata Jain S Gadad A P Kulkarni A R | 2007 | International Journal of Pharmaceutics2007，328，： | 1 |
| 8 | Efficacy of various collection methods for oocyte retrieval in buffalo 显示文摘 | DAS G K JAIN G C SOLANKI V S | 1996 | Theriogenology1996，46，8： | 1 |
| 9 | Why the bass model fits without decision variables显示文摘 | Bass F M Kvishnan T V Jain D C | 1994 | Marketing Science1994，13，3： | 1 |
| 10 | Modeling of material removal and surface roughness in abrasive flow machining process显示文摘 | Jain R K Jain V K Dixit P M | 1999 | International Journal of Machine Tools & Manufacture1999，39，19： | 1 |
| 11 | Characterization and identification of forming features for 3-D sheet metal components显示文摘 | Jagirdar R Jain V K Batra J L | 2001 | International Journal of Machine Tools and Manufacture2001，41，9： | 1 |
| 12 | Acetyl-L-carni- tine (ALCAR) prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-medi- ated nuclear factor erythroid 2 related factor 2 phosphorylation 显示文摘 | BARHWAL K HOTA S K JAIN V | 2009 | Neuroscience2009，161，： | 1 |
| 13 | Reconstruction of through-and-through cheek defects involving the oral commissure,using chimeric flaps from the thigh lateral femoral circumflex system显示文摘 | Huang WC Chen HC Jain V | 2002 | Plast Reconstr Surg2002，109，： | 1 |
| 14 | The twin-twin transfusion syndrome 显示文摘 | Jain V Fisk N Frcog | 2004 | Clin Obstet Gyneco12004，47，1： | 1 |
| 15 | A new algorithm for rapid tracking of appzopmate mximum powe point in photovohaic systems显示文摘 | Jain S Agarwal V | 2004 | IEEE Power Electronics Letters2004，2，1： | 1 |
| 16 | Activated carbons derived from coconut shells as high energy density cathode material for Li-ion capacitors显示文摘 | JAIN A ARAVINDAN V JAYARAMAN S | 2013 | Sci Rep2013，3，： | 1 |
| 17 | Effect of Bombax ceiba root on some cardiovascular risk parameters in patients with ischemic heart disease 显示文摘 | Jain V Verma S K Katewa S S | 2012 | Asian Journal of Biological Sciences2012，，5： | 1 |
| 18 | Modeling and analysis of wafer fabrication scheduling via generalized stochastic Petri net and simulated annealing 显示文摘 | Jain V Swarnkap R Tiwari M K | 2003 | International Journal of Production Research2003，41，15： | 1 |
| 19 | Parallel EFG algorithm for heat transfer problems显示文摘 | SINGH I V JAIN P K | 2005 | Advances in Eng Software2005，36，8： | 1 |
| 20 | Impact of interference on multi-hop wireless network performance 显示文摘 | Jain K Padhye J Padmanabhan V N | 2005 | Wireless Networks2005，11，4： | 1 |
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