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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction显示文摘 | Wei C. Lau Lucy A. Waskell Paul B. Watkins Charlene J. Neer Kevin Horowitz Amy S. Hopp Alan R. Tait David G.M. Carville Kirk E. Guyer Eric R. Bates | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 3 |
| 3 | Machine vision and image processing for plant identification显示文摘 | Guyer D E Miles G E | 1986 | Transactions of the ASAE1986，29，6： | 2 |
| 4 | Bovine growth hormone- human food safety evaluation显示文摘 | JUSKEVICH J C GUYER C G | 1990 | Science1990，249，： | 2 |
| 5 | Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance显示文摘 | Wei C. Lau Paul A. Gurbel Paul B. Watkins Charlene J. Neer Amy S. Hopp David G.M. Carville Kirk E. Guyer Alan R. Tait Eric R. Bates | 2004 | Circulation: Journal of the American Heart Association2004，，2： | 2 |
| 6 | Nonlinear resonance ultrasound spectroscopy(NRUS) applied to damage assessment in bone显示文摘 | MULLER M SUTIN A GUYER R | 2005 | The Journal of the Acoustical Society of America2005，118，6： | 1 |
| 7 | Supercritical carbon dioxide extraction of flavors and their analysis by gas chromatography-mass spectrometry显示文摘 | Sinha N K Guyer D E Gage D A | 1992 | J Agri Food Chem1992，40，： | 1 |
| 8 | Neurological complications of lumbar artifieial disc replacement and comparison of clinical results with those related to lumbar arthrodosis in the literature:results of a muhicenter,prospective,randomized investigational device exemption study of Charite intervertebral disc显示文摘 | Geisler FH Blumenthal SL Guyer RD | 2004 | Nenrosurg Spine2004，1，： | 1 |
| 9 | Pregabalin:A novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain,partial-onset seizures,and anxiety disorders显示文摘 | Tassone D M Boyce E Guyer J | 2007 | Clinical Therapeutics2007，29，1： | 1 |
| 10 | Nonlinear mesoscopical elasticity: evidence for a new class of material显示文摘 | Guyer R A Johnson P A | 1999 | Physics Today1999，52，14： | 1 |
| 11 | Artificial disc:preliminary results of a prospective study in the United States 显示文摘 | Hochschuler SH Ohnmeiss DD Guyer RD | 2002 | Eur Spine J2002，11，2： | 1 |
| 12 | Morphological stability of alloy thin films显示文摘 | GUYER J E VOORHEES P W | 1995 | Phys Rev Lett1995，74，： | 1 |
| 13 | Prospective randomized study of the Charite artificial dise:data from two investi-gational centers显示文摘 | Guyer RO MeAfee PC Hochsehuler SH | 2004 | Spine2004，4，： | 1 |
| 14 | Supercritical carbon dioxide extraction of onion flavors and their analysis by gas chromatography-mass spectrometry显示文摘 | SINHA N K GUYER D E GAGE D A | 1992 | Journal of Agricultural and Food Chemistry1992，40，5： | 1 |
| 15 | Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITEartificial disc versus lumbar fusion: five-year follow-up显示文摘 | Guyer RD Mcafee PC Banco RJ | 2009 | Spine J2009，9，5： | 1 |
| 16 | Microwave ablation for the treatment of hypersplenism:short waves,low cost,big results显示文摘 | Ha J Hendrix M Guyer AG | 2016 | Dig Dis Sci2016，611，1： | 1 |
| 17 | Laparoscopic fusion of the lumbar spine in a multicenter seires of the first 34 consecutive patients显示文摘 | Regan JJ Mcafee PC Guyer RD | 1996 | Sugr Laparosc Endosc1996，6，6： | 1 |
| 18 | Temperature pulses in dielectric solids显示文摘 | Ackerman C C Guyer R A | 1968 | Ann Phys1968，50，1： | 1 |
| 19 | Pregabalin:a novel γ- aminobutyric acid analogue in the treatment of neuropathic pain, partial on set seizures, and anxiety disorders 显示文摘 | Tassone D M Boyce E Guyer J | 2007 | Clin Pharmacol Ther2007，29，1： | 1 |
| 20 | Near-infrared hyperspectml reflec- tance imaging for detection of bruises on pickling cucumbers显示文摘 | ARIANA D P LU R GUYER D E | 2006 | Com- puters and Electronics in Agriculture2006，53，1： | 1 |
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