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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | The fortune at the bottom of the pyramid 显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，26，： | 1 |
| 6 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘 | Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 7 | Palmar-plantar erythrodysesthesia (PPE) : A literature review with commentary on experience in a cancer centre 显示文摘 | Gandy J How C Hart'old K | 2007 | European Journal of Oncology Nursing2007，11，： | 1 |
| 8 | Development of an electrochemical assay for 2, 6 -dinitrotoluene, based on a screen-printed carbon electrode, and its potential application in bioanalysis,occupational and public health 显示文摘 | Honeychurch K C Hart J P Pritchard P R J | 2003 | Biosensors and Bioelectronics2003，19，4： | 1 |
| 9 | Loniceroside C, anantiinflamm, atory saponin from Lorzicera japonica显示文摘 | KWAK W J HART C K CHANG H W | 2003 | ChemPhann BuI12003，51，3： | 1 |
| 10 | IL-8 in sepsis: relation to shock and inflammatory mediators 显示文摘 | Hack C E Hart M Strack van Schijadel K J M | 2002 | Infection and Immunity2002，60，： | 1 |
| 11 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples显示文摘 | Chuang J C Hart K Chang J S | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 12 | The fortune at the bottom of the pyramid显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，，26： | 1 |
| 13 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet Samples显示文摘 | Chuang J C Hart K Chang J S | 2001 | Analytica Chimica Acta2001，444，： | 1 |
| 14 | The fortune at the bottom of the pyra- mid 显示文摘 | PRAHALAD C K HART S | 2002 | Strategy+Business2002，，26： | 1 |
| 15 | Rhinoscleroma显示文摘 | HART C A RAO S K | 2000 | J Med Microbiol2000，49，： | 1 |
| 16 | Identification ofputative methylotrophic and hydrogenotrophic methanogens within sedimenting material and copepod faecal pellets显示文摘 | Ditchfield A K Wilson S T Hart M C | 2012 | Aquatic Mi- crobial Ecology2012，67，2： | 1 |
| 17 | Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression 显示文摘 | Stritt C Stem S Harting K | 2009 | Nat Neurosci2009，12，： | 1 |
| 18 | Plants actively control nitrogen cycling: Uncorking the microbial bottleneck显示文摘 | Chapman S K Langley J A Hart S C Koch G W | 2006 | New Phytologist2006，169，1： | 1 |
| 19 | Social context and perceived effects of drugs on sexual behavior among individuals who use both heroin and cocaine 显示文摘 | Kopetz C E Reynolds E K Hart C L | 2010 | Exp Clin Psychopharmacol2010，18，3： | 1 |
| 20 | Internal cycling of nitrate in soils of a mature coniferous forest显示文摘 | Davidson E A Hart S C Firestone M K | 1992 | Ecology1992，73，： | 1 |
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