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| 1 | Spleen-Yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin显示文摘OBJECTIVE:To study serum visfatin levels in women with polycystic ovary syndrome(PCOS)grouped by Traditional Chinese Medicine(TCM)patterns.To study the correlations of serum visfatin levels with homeostatic model assessment insulin resistance(HOMA-IR),fasting plasma glucose(FPG),fasting insulin(FINS),body mass index(BMI),testosterone(T),total cholesterol(TC),and triglycerides(TG).METHODS:Two hundred and twelve PCOS patients were placed into the following TCM pattern subgroups:Kidney-Yang deficiency(KYD)group,Spleen-Yang deficiency(SYD)group,stagnant Liver-Qi transforming into heat(SLQTH)group,and Kidney-Yin deficiency(KYIND)group.The correlations between serum visfatin levels and HOMA-IR,FPG,FINS,BMI,T,TC,andTG were analyzed.RESULTS:Of all patients with PCOS,there were 82in the KYD group(38.6%),67 in the SYD group(31.6%),37 in the SLQTH group(17.5%),and 26 in the KYIND group(12.3%).Visfatin levels in all PCOS subgroups were higher than those in the control group(P<0.01 or P<0.05).Among these subgroups,the visfatin levels in the SYD group were significantly higher than those in the other three TCM pattern groups(P<0.05).There were no statistical differences among the remaining three pattern groups.The levels of BMI,FINS,HOMA-IR,T,and TG were significantly higher in all subgroups than those in the control group(P<0.05).There were no significant differences in FPG and TC between all PCOS subgroups and the control group(P>0.05).The SYD group had higher levels of FINS and HOMA-IR compared with the KYD,SLQTH,and KYIND groups(P<0.05).In all subgroups,after controlling for BMI,TG,TC,and age,visfatin was positively correlated with FINS(r=0.197,P=0.015)and HOMA-IR(r=0.173,P=0.033),and was not correlated with T.CONCLUSION:KYD and SYD patterns are most common in PCOS patients.Increased visfatin is a common pathophysiologic manifestation in PCOS patients.The SYD group had the highest levels of visfatin,and visfatin was positively correlated with FINS and HOMA-IR. | Huijia Fu Yan Qiu Feng Wei Li Yang Min Xia Huiyu He | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 2 | High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity显示文摘Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials.Herein, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(<10 % in standard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine. | Changhui Fu Chaofeng He Longfei Tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu | 2016 | Science Bulletin2016，61，4： | 5 |
| 3 | Drilling Force and Temperature of Bone under Dry and Physiological Drilling Conditions显示文摘Many researches on drilling force and temperature have been done with the aim to reduce the labour intensiveness of surgery, avoid unnecessary damage and improve drilling quality. However, there has not been a systematic study of mid- and high-speed drilling under dry and physiological conditions(injection of saline). Furthermore, there is no consensus on optimal drilling parameters. To study these parameters under dry and physiological drilling conditions, pig humerus bones are drilled with medical twist drills operated using a wide range of drilling speeds and feed rates. Drilling force and temperature are measured using a YDZ-II01 W dynamometer and a NEC TVS-500 EX thermal infrared imager, respectively, to evaluate internal bone damage. To evaluate drilling quality, bone debris and hole morphology are observed by SEM(scanning electron microscopy). Changes in drilling force and temperature give similar results during drilling such that the value of each parameter peaks just before the drill penetrates through the osteon of the compact bone into the trabeculae of the spongy bone. Drilling temperatures under physiological conditions are much lower than those observed under dry conditions, while a larger drilling force occurs under physiological conditions than dry conditions. Drilling speed and feed rate have a significant influence on drilling force, temperature, bone debris and hole morphology. The investigation of the effect of drilling force and temperature on internal bone damage reveals that a drilling speed of 4500 r/min and a feed rate of 50 mm/min are recommended for bone drilling under physiological conditions. Drilling quality peaks under these optimal parameter conditions. This paper proposes the optimal drilling parameters under mid- and high-speed surgical drilling, considering internal bone damage and drilling quality, which can be looked as a reference for surgeons performing orthopedic operations. | XU Linlin WANG Chengyong JIANG Min HE Huiyu SONG Yuexian CHEN Hanyuan SHEN Jingnan ZHANG Jiayong | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 3 |
| 4 | A genetically encoded ratiometric calcium sensor enables quantitative measurement of the local calcium microdomain in the endoplasmic reticulum显示文摘The local Ca^2+ release from the heterogeneously distributed endoplasmic reticulum (ER) calcium store has a critical role in calcium homeostasis and cellular function. However;single fluorescent proteinbased ER calcium probes experience challenges in quantifying the ER calcium store in differing live cells, and intensity-based measurements make it difficult to detect local calcium microdomains in the ER. Here, we developed a genetically encoded ratiometric ER calcium indicator [GCEPIA1-SNAPer] that can detect the real-time ER calcium store and local calcium microdomains in live cells. GCEPIA1-SNAPer was located in the lumen of the ER and showed a linear;reversible and rapid response to changes in the ER calcium store. The GCEPIA1-SNAPer probe effectively monitored the depletion of the ER calcium store by TG or starvation treatment, and through 让s use we identified heterogeneously distributed calcium microdomains in the ER which were correlated w让h the distribution of STIM1 clusters upon ER calcium store depletion. Lastly, GCEPIA1-SNAPer can be used to detect the ER calcium store by high-throughput flow cytometry and confers the ability to study the function of calcium microdomains of the ER. | Chen Luo Huiyu Wang Qi Liu Wenting He Lin Yuan Pingyong Xu | 2019 | Biophysics Reports2019，5，1： | 3 |
| 5 | Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats显示文摘 | Chao‐YuMiao He‐HuiXie HuiYu Zheng‐XuChu Ding‐FengSu | 2003 | Clinical and Experimental Pharmacology and Physiology2003，，3： | 1 |
| 6 | Rational design of a novel two-dimensional porous metal-organic framework material for efficient benzene sensor显示文摘As a common volatile organic compound,benzene(C_(6)H_(6)) exists in home decoration pollution gas widely,which causes great harm to the environment and human health.Therefore,it is necessary to rationally design advanced materials with high selectivity to detect and capture C_(6)H_(6).Herein,combined with the d-band center theory and cohesive energy,a new two-dimensional metal-organic framework material,Ni-doped hexaaminobenzene-based coordination polymer(Ni-HAB-CP)is designed,and its application potential as a C_(6)H_(6) sensor are systematically investigated by using first principles calculation.The result shows that Ni-HAB-CP has a strong adsorption for C_(6)H_(6) without any additional method.In addition,NiHAB-CP can maintain good conductivity before and after adsorption,and C_(6)H_(6) can be easily desorbed from the surface of Ni-HAB-CP by charge control.Moreover,the I-V curve calculated by Atomistix Toolkit(ATK)reveals that Ni-HAB-CP has high sensitivity and selectivity to C_(6)H_(6).Hence,Ni-HAB-CP is expected to be used as a potential material for a highly efficient and recyclable C_(6)H_(6) sensor in the future.The calculation and analysis methods used in this paper could provide a certain theoretical basis and reference for the future research of gas sensors. | Wenxue Zhang Huiyu Ma Tongtong Li Cheng He | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 7 | The Com prehensive Evaluation on Four Indices of Drug Re-sistance in Acute Myeloid Leukem ia显示文摘To study sensitivity of drug resistance indexes and resistance manner in acute myeloid leukemia (AML), MTT drug sensitivity, growth types of CFU L in vitro , Bcl 2 antigen and Bcl 2/Bax ratio and intracellular fluorescence intensity of daunorubicin (DNR) were determined. In 62 cases of AML, the positive coincidence rate was 73 % with MTT test and the negative coincidence rate was 70 %. In 3 commonly used drugs, if one drug showed sensitivity, the coincidence remission rate reached 71 %. In 51 cases of AML, there were 31 patients in the group of complete remission (CR), in which CFU L of 29 patients showed independent growth. CFU L of 2 patients showed no growth. However, there were 20 patients in the group of non remission (NR), in which CFU L of 14 patients showed independent growth. CFU L of 6 patients showed non growth pattern. Statistical analysis showed significant difference ( P <0.05). In 32 cases of AML, the expression rate of Bcl 2 was 59.55 %±19.56 % in drug sensitive group, and one was 77.36 %±11.91 % in drug resistant group, respectively ( P <0.05). At the same time, the ratio of Bcl 2/Bax was 7.50±5.04 in drug sensitive group and one was 14.32±8.99 in drug resistant group, respectively ( P <0.05). In 15 case of clinically drug resistant AML, the fluorescence histogram of DNR showed left shift of main peak (LSMP) in 12 patients. They were diagnosed as classical drug resistance. Meanwhile, 1 patient showed right shift of main peak (RSMP) in 3 patients. They were diagnosed as re growth drug resistance. It is concluded that MTT and CFU L might be used for prediction of drug sensitivity or resistance when patients were on treatment. Bcl 2 and ratio of Bcl 2/Bax might be associated with the prognosis. DNR histogram could be employed for identify the pattern drug resistance. The strength and weakness of these techniques were discussed. | CHEN Yan , HE Mingsheng , XIANG Zhifu , WU Yudan, YUE Beibei , YU Dongjiao, LI Huiyu Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan, 430022 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 0 |
| 8 | Iodine-assisted ultrafast growth of high-quality monolayer MoS_(2) with sulfur-terminated edges显示文摘Two-dimensional(2D)semiconductors have attracted great attention to extend Moore’s law,which motivates the quest for fast growth of high-quality materials.However,taking MoS_(2) as an example,current methods yield 2D MoS_(2) with a low growth rate and poor quality with vacancy concentrations three to five orders of magnitude higher than silicon and other commercial semiconductors.Here,we develop a strategy of using an intermediate product of iodine as a transport agent to carry metal precursors efficiently for ultrafast growth of high-quality MoS_(2).The grown MoS_(2) has the lowest density of sulfur vacancies(~1.41×10^(12) cm^(−2))reported so far and excellent electrical properties with high on/off current ratios of 108 and carrier mobility of 175 cm^(2) V^(−1) s^(−1).Theoretical calculations show that by incorporating iodine,the nucleation barrier of MoS_(2) growth with sulfur-terminated edges reduces dramatically.The sufficient supply of precursor and low nucleation energy together boost the ultrafast growth of sub-millimeter MoS_(2) domains within seconds.This work provides an effective method for the ultrafast growth of 2D semiconductors with high quality,which will promote their applications. | Qinke Wu Jialiang Zhang Lei Tang Usman Khan Huiyu Nong Shilong Zhao Yujie Sun Rongxu Zheng Rongjie Zhang Jingwei Wang Junyang Tan Qiangmin Yu Liqiong He Shisheng Li Xiaolong Zou Hui-Ming Cheng Bilu Liu | 2023 | National Science Open2023，2，4： | 0 |
| 9 | First experimental comparisons of laser-plasma interactions between spherical and cylindrical hohlraums at SGⅢ laser facility显示文摘We present our recent laser-plasmas instability(LPI)comparison experiment at the SGIII laser facility between the spherical and cylindrical hohlraums.Three kinds of filling are considered:vacuum,gas-filling with or without a capsule inside.A spherical hohlraum of 3.6 mm in diameter,and a cylindrical hohlraum of 2.4 mm?4.3 mm are used.The capsule diameter is 0.96 mm.A flat-top laser pulse with 3 ns duration and up to 92.73 kJ energy is used.The experiment has shown that the LPI level in the spherical hohlraum is close to that of the outer beam in the cylindrical hohlraum,while much lower than that of the inner beam.The experiment is further simulated by using our 2-dimensional radiation hydrodynamic code LARED-Integration,and the laser back-scattering fraction and the stimulated Raman scatter(SRS)spectrum are post-processed by the high efficiency code of laser interaction with plasmas HLIP.According to the simulation,the plasma waves are strongly damped and the SRS is mainly developed at the plasma conditions of electron density from 0.08 n_(c) to 0.1 n_(c) and electron temperature from 1.5 keV to 2.0 keV inside the hohlraums.However,obvious differences between the simulation and experiment are found,such as that the SRS back-scattering is underestimated,and the numerical SRS spectrum peaks at a larger wavelength and at a later time than the data.These dif-ferences indicate that the development of a 3D radiation hydrodynamic code,with more accurate physics models,is mandatory for spherical hohlraum study. | Yaohua Chen Zhichao Li Xufei Xie Chunyang Zheng Chuanlei Zhai Liang Hao Dong Yang Wenyi Huo Guoli Ren Jie Liu Xiaoshi Peng Tao Xu Yulong Li Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Yonggang Liu Huiyue Wei Xiangming Liu Weiyi Cha Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Haijun Zhang Baibin Jiang Wei Zhang Kai Du Xuewei Deng Yongkun Ding Xiaofeng Wei Wanguo Zheng Xiaodong Chen Xiantu He Ke Lan | 2017 | Matter and Radiation at Extremes2017，2，2： | 0 |
| 10 | BCL9 regulates CD226 and CD96 checkpoints in CD8^(+)T cells to improve PD-1 response in cancer显示文摘To date,the overall response rate of PD-1 blockade remains unsatisfactory,partially due to limited understanding of tumor immune microenvironment(TIME).B-cell lymphoma 9(BCL9),a key transcription co-activator of the Wnt pathway,is highly expressed in cancers.By genetic depletion and pharmacological inhibition of BCL9 in tumors,we found that BCL9 suppression reduced tumor growth. | Mei Feng Zhongen Wu Yan Zhou Zhuang Wei Enming Tian Shenglin Mei Yuanyuan Zhu Chenglong Liu Fenglian He Huiyu Li Cao Xie Joy Jin Jibin Dong Dehua Yang Ker Yu Junbin Qian Diether Lambrechts Ming-Wei Wang Di Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 0 |
| 11 | 利用微孔板测序技术绘制小鼠细胞图谱显示文摘文章简介长久以来,生命科学的研究主要基于群体细胞水平的分析,近几年所涌现的单细胞组学技术,使我们能够从单个细胞的水平上更为精确的解析细胞的分化、再生、衰老以及病变。在本研究中,科研团队自主开发了一套完全国产化的Microwell-seq高通量单细胞测序平台. | Xiaoping Han Renying Wang Yincong Zhou Lijiang Fei Huiyu Sun Shujing Lai Assieh Saadatpour Ziming Zhou Haide Chen Fang Ye Daosheng Huang Yang Xu Wentao Huang Mengmeng Jiang Xinyi Jiang Jie Mao Yao Chen Chenyu Lu Jin Xie Qun Fang Yibin Wang Rui Yue Tiefeng Li He Huang Stuart H.Orkin Guo-Cheng Yuan Ming Chen 郭国骥 | 2019 | 科学新闻2019，0，2： | 0 |
| 12 | Basic models of farfield ship waves in shallow water显示文摘Basic models of the farfield waves created by a monohull ship or a catamaran that travels at a constant speed in calm water of uniform finite depth are considered.A classical basic model is the 1-point ship model introduced by Kelvin in 1887 for deep water and extended to uniform finite water depth by Havelock in 1908.Another basic model is the 2-point ship model,which considers the two dominant waves created by the bow and the stern of a monohull ship or by the twin bows of a catamaran,and therefore accounts for main wave interference effects.These 2-point ship models contain information that cannot be found in the classical patterns for the 1-point ship model commonly used since Kelvin.In particular,whereas Havelock’s classical wave patterns for the 1-point model only depend on the Froude number based on the water depth,the farfield waves for the 2-point models of a monohull ship or a catamaran also depend on the Froude number associated with the length of the monohull ship or the spacing between the twin hulls of the catamaran.Moreover,the‘apparent wake angles’associated with the highest waves that result from constructive wave interferences can greatly differ from the cusp or asymptote angles of Havelock’s wave patterns. | Yi Zhu Jaiyi He Huiyu Wu Wei Li Francis Noblesse | 2018 | Journal of Ocean Engineering and Science2018，3，2： | 0 |
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