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| 1 | Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke显示文摘Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their functions.The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these treatments.Memantine is an approved drug for the treatment of Alzheimer's disease.Memantine is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate receptor.Memantine has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical trials.The present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients. | Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 2 | Slructure and species distribution in Coringa mangrove forest, Godavari Delta, Andhra Pradesh India显示文摘 | Azariah Jayapaul Azariah Hilda Gunasekaran S and Selvam V | 1992 | Hydrobiologia1992，247，： | 1 |
| 3 | Purification of keratinase from poll]try farm isolate - scopuariopsis brevicanlis and statistical optimization of enzyme ac- tivity 显示文摘 | Aubu P Gopinath S C B Hilda A | 2005 | Enzyme and Mierobial Tech- nology2005，36，56： | 1 |
| 4 | Characterization of a predominant immunogenic outer membrane protein of Riemerella anati pestifer 显示文摘 | SUMATHI S HUANG B HILDA L | 2000 | Clin Diagn Lab Immun2000，7，2： | 1 |
| 5 | Characterization of a predominant immunogenic outer membrane protein of Riemerella anatipestifer 显示文摘 | Sumathi S Huang B Hilda L | 2000 | Clin Diagn Lab Immunol2000，7，2： | 1 |
| 6 | The effect of crude lecithin on the coefficient of digestibility and the rate of absorption of fat显示文摘 | AUGUR V HILDA S ROLLMAN | 1947 | J Nutr1947，33，2： | 1 |
| 7 | Environmental heterogeneity and spatial distribution of macrophytes in plain streams显示文摘 | HILDA P GANTES A SáNCHEZ C | 2001 | Aquatic Botany2001，70，： | 1 |
| 8 | The Effect of Crude Lecithin on the Coefficient of Digestibility and the Rate of Absorption of Fat显示文摘 | Augur V Hilda S Rollman | 1947 | The Journal of nutrition1947，33，2： | 1 |
| 9 | Purification of keratinase from poultry farm isolate-Scopulariopsis brevicaulis and statistical optimization of enzyme activity显示文摘 | Anbu P Gopinath S C B Hilda A | 2005 | Enzyme and Microbial Technology2005，36，： | 1 |
| 10 | Purifieation of keratinase from poultry farm isolate-scopulariopsis breicaulis and statistical optimization of enzyme activity显示文摘 | Anbu P Gopinath S C Hilda A | 2005 | Enzyme and Microbial Tech nology2005，36，56： | 1 |
| 11 | Craniofacial Surgery for Esthesioneuroblastoma: Report of an International Collabora tiveStudy显示文摘 | Snehal GP Bhuvanesh S Hilda ES | 2012 | J NeurolSurgB2012，73，3： | 1 |
| 12 | Purification of keratinase from poultry farm isolate - Scopulariopsisbrevieaulis and statistical optimization of enzyme ac- tivity 显示文摘 | Anbu P Gopinath S C B Hilda A | 2005 | Enzyme and Microbial Tech- nology2005，36，56： | 1 |
| 13 | Enrichment and determination of molybdenum in geological samples and seawater by ICP-AES using calmagite and activated carbon显示文摘 | Hilda C. dos Santos Maria G.A. Korn Sérgio L.C. Ferreira | 2001 | Analytica Chimica Acta2001，，1： | 1 |
| 14 | Purification of keratinase from poultry farm isolate-Scopulariopsis brevicaulis and statistical optimization of enzyme activity显示文摘 | Aubu P Gopinath S C B Hilda A | 2005 | Enzyme Microb Tech2005，36，： | 1 |
| 15 | Purification of keratinase from poultry farm isolate-Scopulariopsis brevicaulis and statistical optimization of enzyme activity显示文摘 | Gopinatha S C B Hilda A | 2005 | Enzyme and Microbial Technology2005，36，： | 1 |
| 16 | Purification of keratinase from poultry farm isolate Scopulariopsis brevicaulis and statistical opti-mization of enzyme activity显示文摘 | Anbu P Gopinath S C B Hilda A | 2005 | Enzyme and Microbiological Technol-ogy2005，36，： | 1 |
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