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| 1 | Lysophos- phatidic acid receptors in cancer pathobiology 显示文摘 | TSUJIUCHI T ARAKI M HIRANE M | 2014 | Histol His- topathol2014，29，3： | 1 |
| 2 | Wet spun chitosan-collagen fibers , their chemical N-modifications, and blood compatibility 显示文摘 | Hirane S Zhang M Nakagawa M | 2000 | Biomaterials2000，21，10： | 1 |
| 3 | Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells 显示文摘 | ISHII S HIRANE M FUKUSHIMA Kaori | 2015 | Biochem Biophys Res Commun2015，461，1： | 1 |
| 4 | Lysophospha- tidic acid receptor-5 negatively regulates cell motile and inva- sire activities of human sarcoma cell lines 显示文摘 | DONG Yan HIRANE M ARAKI M | 2014 | Mol Cell Bio- chem2014，393，12： | 1 |
| 5 | Wet spun chitosan-collagen fibers,their chemical N-modifications,and blood com-patibility显示文摘 | Hirane S Zhang Min Nakagawa M | 2000 | Biomaterials2000，21，10： | 1 |
| 6 | Wet spun chitosan collagen fibers,their chemical modification,and blood compatibility显示文摘 | Hirane S Zhang M Nakagawa M | 2000 | Biomaterials2000，，21： | 1 |
| 7 | Role of bronchial artery embolization in the management of hemoptysis显示文摘 | Femando Hiran C Stein M Benfield J R | 1998 | Arch Surg1998，133，： | 1 |
| 8 | Effects of endosul- fan on brain acetylcholinesterase activity in juvenile blue gill sunfish显示文摘 | Hiran M Dutta Dane A Arends | 2003 | Environmental Research2003，91，3： | 1 |
| 9 | Wet-spun chitosan-collagen fibers,their chemical modifications,and bloodcompatibility显示文摘 | HIRANE S ZHANG Min NAKAGAWA M | 2000 | Biomaterials2000，，21： | 1 |
| 10 | Wet spun chitosan collagen fibers, their chemical modification, and blood compatibility 显示文摘 | Hirane S Zhang M Nakagawa M | 2000 | Biomaterials2000，，21： | 1 |
| 11 | Fibrin sealant for esophageal anastomosis:A phase II study显示文摘BACKGROUND Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer(EC or EJC).Postoperative anastomotic leakage(AL)remains problematic.The use of fibrin sealant(FS)may improve the strength of esophageal anastomosis and reduce the incidence of AL.AIM To assess the efficacy and safety of applying FS to prevent AL in patients with EC or EJC.METHODS In this single-arm,phase II trial(Clinicaltrial.gov identifier:NCT03529266),we recruited patients aged 18-80 years with resectable EC or EJC clinically staged as T1-4aN0-3M0.An open or minimally invasive McKeown esophagectomy was performed with a circular stapled anastomosis.After performing the anastomosis,2.5 mL of porcine FS was applied circumferentially.The primary endpoint was the proportion of patients with AL within 3 mo.RESULTS From June 4,2018,to December 29,2018,57 patients were enrolled.At the data cutoff date(June 30,2019),three(5.3%)of the 57 patients had developed AL,including two(3.5%)with esophagogastric AL and one(1.8%)with gastric fistula.The incidence of anastomotic stricture and other major postoperative complications was 1.8%and 17.5%,respectively.The median time needed to resume oral feeding after operation was 8 d(Interquartile range:7.0-9.0 d).No adverse events related to FS were recorded.No deaths occurred within 90 d after surgery.CONCLUSION Perioperative sealing with porcine FS appears safe and may prevent AL after esophagectomy in patients with resectable EC or EJC.Further phase III studies are warranted. | Yao-Bin Lin Jian-Hua Fu Yan Huang Yi-Huai Hu Kong-Jia Luo Ke-Xi Wang AmosÉla Bella Dong-Rong Situ Ji-Yang Chen Ting Lin Xavier B D’Journo Nuria M Novoa Alessandro Brunelli Hiran C Fernando Robert J Cerfolio Mahmoud Ismail Hong Yang 无 | 2020 | World Journal of Gastrointestinal Oncology2020，12，6： | 0 |
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