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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | (+)Abscisic acid, the growth inhibitor induced in detached leaves by a period of wilting显示文摘 | Wright S T C Hiron R W P | 1969 | Natrue1969，224，： | 1 |
| 3 | The inflammation-induced down-regulation of plasma Fetuin-A (2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites显示文摘 | Gangneux C Daveau M Hiron M | 2003 | Nucleic Acids Res2003，31，20： | 1 |
| 4 | Intermediates and products of the biohydrogena- tiou of linoleic acid by Butydvibrio fib- risolvens 显示文摘 | KEPLER CR HIRONS KP MCNEILL J J | 1966 | Bioi Chem1966，241，： | 1 |
| 5 | Intermediates and products of the biohydrogenation of linoleic acid by bu- :yrivibriofibrisolvens 显示文摘 | Kepler C R Hirons K P McNeil J J | 1966 | The Journal of Biological chemis- Lry1966，241，6： | 1 |
| 6 | Uhrastructure of giant pigment granules in lentigo simplex显示文摘 | Hirone T Eryu Y | 1978 | Acta Derm Venereol1978，58，： | 1 |
| 7 | Intermediates and products of the biohydrogrnation of linoleic acid by Butyrivibrio fibrisolvens 显示文摘 | Kepler C R Hirons K P Mcneill J J | 1966 | The Journal of Biological Chemistry1966，241，6： | 1 |
| 8 | Abscisic acid, the growth inhibitor induced in detached leaves by a period of wilting 显示文摘 | Wright S T C Hiron R W P | 1969 | Nature1969，24，： | 1 |
| 9 | The inflammation-induced down-regulation of plasma Fetuin A (alpha2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites显示文摘 | Gangneux C Daveau M Hiron M | 2003 | Nucleic Acids Res2003，31，20： | 1 |
| 10 | Genome-wide differences in hepatitis C-vs alcoholism-associated hepatocellular carcinoma显示文摘AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis C,10)and 5 controls.Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis C)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis C).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis.These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C.This may open novel avenues for differential therapies in this disease. | Céline Derambure Cédric Coulouarn Frédérique Caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois Celia Duclos Odile Goria Marie Gueudin Catherine Cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier | 2008 | World Journal of Gastroenterology2008，14，11： | 1 |
| 11 | Intermediates and products of the biohydrogenation of C18 unsaturated fatty acids 显示文摘 | Kepler C R Hirons K P McNeill J J | 1966 | J Biol Chem1966，241，： | 1 |
| 12 | Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibri- solvens 显示文摘 | Kepler C R Hirons K P McNeill J J | 1966 | J Biol Chem1966，241，： | 1 |
| 13 | Intermediates and products of the biohydrogenation of linolic acid by butyrivibrio fibrisolvens 显示文摘 | Kepler C R Hirons K P McNell J J | 1966 | The Journal of Biological Chemistry1966，241，6： | 1 |
| 14 | Ultrastructure of giant pigment granules in lentigo simplex显示文摘 | Hirone T Eryu Y | 1978 | Acta Derm Venereol1978，58，3： | 1 |
| 15 | TOTO and YOYO:new very bright fluorochromes for DNA content analyses by flow cytometry显示文摘 | Hirons GT Fawcett JJ Crissman HA | | 0，，： | 1 |
| 16 | Benzotriazole as inhibitor for copper with and without corrosion products in aqueous polyethylene glycol显示文摘 | E. Guilminot J-J. Rameau F. Dalard C. Degrigny X. Hiron | 2000 | Journal of Applied Electrochemistry2000，，1： | 1 |
| 17 | Novel serum markers of fi- brosis progression for the follow-up of hepatitis C virus-infected patients显示文摘 | Caillot F Hiron M Goria O | 2009 | Am J Pathol2009，175，1： | 1 |
| 18 | Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens显示文摘 | KEPLER C R HIRONS K P MCNEILL J J | | 0，，： | 1 |
| 19 | Distinct methylated profiles in helicobacter py]ori dependent and independent gastric MALT lymphomas显示文摘 | Kaneko Y Sakurai S Hiron aka M | 2003 | Gut2003，52，5： | 1 |
| 20 | Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens显示文摘 | Kepler C R Hirons K P Mcneill J J | 1966 | Journal of Biological Chemistry1966，241，6： | 1 |
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