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| 1 | Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus显示文摘AIM:To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE).METHODS:Electronic pathology database established in the Department of Pathology of the Nanjing Drum Tower Hospital was searched for consecutive resection cases of proximal gastric carcinoma over the period from May 2004 through July 2009.Each retrieved pathology report was reviewed and the cases with tumors crossing the gastroesophageal junction line were selected as PGCE.Each tumor was re-staged,following the guidelines on esophageal adenocarcinoma,according to the 7th edition of the American Joint Commission on Cancer Staging Manual.All histology slides were studied along with the pathology report for a retrospective analysis of 13 clinicopathologic features,i.e.,age,gender,Helicobacter pylori (H.pylori ) infection,surgical modality,Siewert type,tumor Bormann's type,size,differentiation,histology type,surgical margin,lymphovascular and perineural invasion,and pathologic stage in relation to survival after surgical resection.Prognostic factors for overall survival were assessed with uniand multi-variate analyses.RESULTS:Patients' mean age was 65 years (range:47-90 years).The male:female ratio was 3.3.The 1-,3and 5-year overall survival rates were 87%,61% and 32%,respectively.By univariate analysis,age,male gender,H.pylori ,tumor Bormann's type,size,histology type,surgical modality,positive surgical margin,lymphovascular invasion,and pT stage were not predictive for overall survival;in contrast,perineural invasion (P = 0.003),poor differentiation (P = 0.0003),> 15 total lymph nodes retrieved (P = 0.008),positive lymph nodes (P = 0.001),and distant metastasis (P = 0.005) predicted poor post-operative overall survival.Celiac axis nodal metastasis was associated with significantly worse overall survival (P = 0.007).By multivariate analysis,≥ 16 positive nodes (P = 0.018),lymph node ratio > 0.2 (P = 0.003),and overall pathologic stage (P = 0.002) were independent predictors for poor overall survival after resection.CONCLUSION:Patients with PGCE showed worse overall survival in elderly,high nodal burden and advanced pathologic stage.This cancer may be more accurately staged as gastric,than esophageal,cancer. | Yi-Fen Zhang Jiong Shi Hui-Ping Yu An-Ning Feng Xiang-Shan Fan Gregory Y Lauwers Hiroshi Mashimo Jason S Gold Gang Chen Qin Huang | 2012 | World Journal of Gastroenterology2012，18，27： | 12 |
| 2 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 3 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 4 | Mathematical models for predicting microstructure evolution and mechanical properties of hot strips显示文摘 | Takenide S Masayoshi S Hiroshi Y | 1992 | ISIJ International1992，32，11： | 1 |
| 5 | Automatic Detection of Gust Fronts显示文摘 | Hiroshi Uyeda Dusan S Zrnic | 1986 | J Atmos Oceanic Technol1986，3，： | 1 |
| 6 | Creep deformation behavior and dislocation substructures of Mg-Y binary alloys显示文摘 | MAYUMI S HIROYUKI S KOUICH M HIROSHI O | 2001 | Materials Science and Engineering A2001，，： | 1 |
| 7 | Comparison of 2D and 3D carbon/carbon com- posites with respect to damage and fracture re- sistance 显示文摘 | Mohamed S Aly - Hassana Hiroshi Hatta | 2003 | Carbon2003，41，： | 1 |
| 8 | Antitumour triterpenes of Maytenus diversifolia 显示文摘 | Hiroshi N Hideyo S Teruhisa H | 1986 | Phytochemistry1986，25，2： | 1 |
| 9 | Increased carotenoid production by the food yeast candida utilis through metabolic engineering of the isoprenoid pathway显示文摘 | HIROSHI S KEIJI K PAUL D | 1998 | Appl Environ Mierobiol1998，64，7： | 1 |
| 10 | Immunological characteristics of patients with vernal keratoconjunctivitis显示文摘 | Hiroshi F Ichiro S Tsutomu T | 2002 | Jpn J Ophthalmol2002，46，： | 1 |
| 11 | Introduction on the protective gas of the new GWP≈1 magnesium alloy显示文摘 | Hiroshi S Yuuji N Masakazu K | 2004 | Materia2004，43，4： | 1 |
| 12 | Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma显示文摘 | Naomi T Hiroshi S Takahiro T | | 0，，03： | 1 |
| 13 | Development and validation of a microplate-basedβ-carotene bleaching assay and comparison of antioxidant activity(AOA)in several crops measured byβ-carotene bleaching,DPPH and ORAC assays显示文摘 | Ichiho M Minako Y Hiroshi S | 2009 | Food Science and Technology Research2009，15，2： | 1 |
| 14 | A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population显示文摘 | Ken S Hiroshi A Tomohiro K et a l | 2008 | Hypertension2008，52，6： | 1 |
| 15 | Duplex real-time SYBR green PCR assays for detection of 17 species of food or waterborne pathogens in stools显示文摘 | Hiroshi F Yoshie T Yrothro S | 2003 | J Clim Microbiol2003，41，： | 1 |
| 16 | Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid generation显示文摘 | Masayuki K Hiroshi K Ryo S | 2010 | J Neurosci Res2010，30，11： | 1 |
| 17 | Comparison of paralytic shellfish poisoning toxin between carnivorous crabs (Telmessus acutidens and Charybdis japonica) and their prey mussel (Mytilus galloprovincialis) in an inshore food chain显示文摘 | HIROSHI O TSUNEO F KEN S | 2004 | Toxicon2004，43，： | 1 |
| 18 | Expression of genes encoding type Ⅳ collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells显示文摘 | Hiroshi S Yuri K Masayoshi M | 1992 | Oncogene1992，7，： | 1 |
| 19 | Inflammatory cytokines in the herniated disc of the lumbar spine 显示文摘 | Hiroshi T Toru S Yukikazu O | 1996 | Spine1996，21，2： | 1 |
| 20 | Fatty acid composition of five candidate aquaculture species in Central Philippines 显示文摘 | Ogata Hiroshi Y Emata Amil C Garibay Esteban S | 2004 | Aquacultre2004，236，： | 1 |
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