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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Outcome analysis of intraventricular thrombolytic therapy for intraventricular haemorrhage 显示文摘 | LEE M W PANG K Y HO W W | 2003 | Hong Kong Med J2003，9，5： | 1 |
| 3 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 4 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 5 | Gaseous and particulate polycyclic aromatic hydrocarbons (PAHs) emissions from Commercial Restaurants in Hong Kong 显示文摘 | Chen Y Ho K F Ho S S | 2007 | Journal of Environment Monitoring2007，9，： | 1 |
| 6 | Improved accuracy of computer --asssisted cervical pediele screw insertion显示文摘 | Kotani Y Abumi K ho M | 2003 | J Neurosurg2003，99，3： | 1 |
| 7 | Coherent Optical OFDM Transmitter Design Employing Predistortion 显示文摘 | TANG Y HO K P SHIEH W | 2008 | 1EEE Photonics Technology Letters2008，20，11： | 1 |
| 8 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 9 | Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids 显示文摘 | Shen C C Chang Y S Ho L K | 1993 | Phytochem1993，34，3： | 1 |
| 10 | Prognostic valules of matrixmetalloproteinase 2 and tissue in inhibitor of metalloproteinase-2 exproession bladder cancer显示文摘 | Kanayama HO Yokta K Kurokawa Y | 1998 | Cancer1998，82，7： | 1 |
| 11 | Some volatile compounds formed from thermal interaction of glucose with glycine,diglycine,triglycine,and tetraglycine显示文摘 | Oh Y C Shu C K Ho C T | 1991 | J Agric Food Chem1991，39，： | 1 |
| 12 | Immunosuppressive drugs prevent a rapid dephos?phorylation of transcription factor NF A Tl in stimulated immune cells显示文摘 | SHAW K T Y HO A M RAGHAVAN A | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 13 | Positive sampling artifacts in particulate organic carbon measurements in roadside environment显示文摘 | CHENG Y LEE S C HO K F | 2010 | Environmental Monitoring and Assessment2010，168，1234： | 1 |
| 14 | Colorectal neoplasia in Asia: a multicenter colonscopy survey in symptomatic patients显示文摘 | LEUNG W K HO K Y KIM W H | 2006 | Gastrointest Endosc2006，64，： | 1 |
| 15 | Adaptive fuzzy sliding mode control with chattering elimination for nonlinear SISO systems 显示文摘 | Ho H F Wong Y K Rad A B et | 2009 | Simulation Modelling Practice and Theory2009，17，7： | 1 |
| 16 | Size, leverage, concentration, and R&D investment in generating growth opportunities 显示文摘 | Ho Y K Tjahjapraata M Yap C M | 2006 | Journal of Business2006，79，2： | 1 |
| 17 | Geolocation of a known altitude object from TDOA and FDOA measurements 显示文摘 | Ho K C Chan Y T | 1997 | IEEE Transac- tions on Aerospace and Electronic Systems1997，33，3： | 1 |
| 18 | Relationships between explanatory style, posttraumatic growth and posttraumatic stress disorder symptoms among Chinese breast cancer patients显示文摘 | Ho S M Y Chart M W Y Yau T K | 2011 | Psychology and Health2011，，3： | 1 |
| 19 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 20 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
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