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| 1 | Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production. | Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler | 2009 | World Journal of Gastroenterology2009，15，12： | 12 |
| 2 | 全新世大暖期时中国夏季风向西北大幅度漂移的一个古生物地层学证据显示文摘巴丹吉林沙漠东南部边缘巴丹海子全新世大暖期6-9kaBP的湖相沉积中含有大量腹足类化石——Radix cucunorica (Moellendorff), Succinea erythrophana Ancey, Gyraulus sibricus (Dunker), Radix lagotis (Schranck), Gyraulus albus(Miiller), Lymnaea stagnalis(Linnaeus),Gyraulus convexiusculus (HuRon),除Succinea erythrophana Ancey属陆生蜗牛外,余皆为淡水腹足类。这些化石代表了当时温暖湿润的气候环境。其中,现生的Gyraulus convexiusculus (Hutton)生活的最NW位置为地处暖温带的南泥湾,据此推知,6-9kaBP时的巴丹海子的气温和降水至少较今分别高出1.1℃和440mnl;从南泥湾至巴丹海子,气候带向NW移动了差不多700km;那时夏季风暖锋位置可向NW移动到从玉门其以NE走向至额济纳旗及其以北的中蒙国界一线,夏季风的波及范围可以漂越甘新交界的深居内陆的星星峡。 | 李保生 HOFMANN Jürgen 陈德牛 温小浩 闫满存 ZHANG David Dian 牛东风 李志文 邱世藩 王丰年 杜恕环 | 2010 | 地球环境学报2010，1，2： | 5 |
| 3 | Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease显示文摘 | Christoph Bickel Hans J Rupprecht Stefan Blankenberg Gerd Rippin Gerd Hafner Alexander Daunhauer Klaus-Peter Hofmann Jürgen Meyer | 2002 | The American Journal of Cardiology2002，，1： | 2 |
| 4 | Influence of Chromium Endowment and Surface Area of Silica-alumina Catalysts of Reaction Conditions on Benzene Synthesis 显示文摘 | Becker-heidmann P Hiller A Hofmann J | 1995 | Radiocarbon1995，37，2： | 2 |
| 5 | Effects of PTK787/ZK 222584,a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases,on primary tumor,metastasis,vessel density,and blood flow in a murine renal cell carcinoma model显示文摘 | Hofmann I Hugenschmidt H | 2000 | Cancer Res2000，60，17： | 1 |
| 6 | 显示文摘 | Wells J W Kallehauge J F Hofmann P | 2007 | J Phys:Condens Matter2007，19，17： | 1 |
| 7 | Effects of peripheralblood stem cell mobilization with granulocyte-colony stimulating fac-tor and their transcoronary transplantation after primary stent implanta-tion for acute myocardial infarction显示文摘 | Steinwender C Hofmann R Kammler J | 2006 | Am Heart J2006，15，6： | 1 |
| 8 | Power quality assessment via wavelet transform analysis 显示文摘 | Santoso S Powers E J Hofmann P | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 9 | Internal fixation of proximal humeral fractures: current concepts显示文摘 | Hessmann MH Blum J Hofmann A | 2003 | Eur J Trauma2003，29，5： | 1 |
| 10 | Attenuation of classical swine fever virus by deletion of the viral N(pro) gene 显示文摘 | Mayer D Hofmann M A Tratschin J D | 2004 | Vaccine2004，22，34： | 1 |
| 11 | A cold-active extracellular metalloprotease from Pedobacter cryoconitisproduction and properties显示文摘 | Margesin R Dieplinger H Hofmann J | 2005 | Research in Microbiology2005，156，4： | 1 |
| 12 | A Short Historical Sketch of Hackett Medical College and Affiliated Institutions显示文摘 | Hofmann J Allen | 1926 | The China Medical Journal1926，40，8： | 1 |
| 13 | Effect of fieldbus technology on digital instrumentation and control for power plants:Instrumentation and control in nuclear power plants显示文摘 | HOFMANN H SAUER H J | 1995 | Kerntechnik1995，60，56： | 1 |
| 14 | Internalfixation of proximal humeral fracture:current concepts显示文摘 | Hessmann MH Blum J Hofmann A | 2003 | Eur J Trauma2003，29，5： | 1 |
| 15 | Implementation of chlorine dioxide disinfection: effects of the treatment change on drinking water quality in a full-scale distribution system显示文摘 | VOLK C J HOFMANN R CHAURET C | 2002 | Environ Eng Sci2002，1，5： | 1 |
| 16 | Experimental studies and first clinical experience with a new lithoclast and ultrasound combination for lithotripsy显示文摘 | Hofmann R Weber J Heidenreich A | 2002 | European Urology2002，42，： | 1 |
| 17 | Clinical Experience with A New Ultrasonic and LithoClast Combination for Percutaneous Litholapaxy显示文摘 | Hofmann R Olbert P Weber J | 2002 | BJU Lint2002，90，： | 1 |
| 18 | Rotational malalignmentof the components may cause chronic pain or early failure in total kneearthroplasty显示文摘 | Hofmann S Romero J Roth-Schiffl E | 2003 | Orthopade2003，32，6： | 1 |
| 19 | New insights to the MLL recombinome of acute leukemias显示文摘 | Meyer C Kowarz E Hofmann J Renneville A Zuna J Trka J Ben Abdelali R Macintyre E De Braekeleer E De Braekeleer M Delabesse E de Oliveira MP Cavé H Clappier E van Dongen JJ Balgobind BV van den Heuvel-Eibrink MM Beverloo HB Panzer-Grümayer R Teigler-Schleg | | 0，，08： | 1 |
| 20 | Precambrian biota from the Little Dal Group, Mackenzie Mountains, northwestern Canada显示文摘 | Hofmann H J Aitken J D | 1979 | Canadian Journal of Earth Sciences1979，16，1： | 1 |
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