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8篇 您的检索式：作者名="Werner Falk"

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		题名	作者	年代	出处	被引量
	1	Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production.	Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler	2009	World Journal of Gastroenterology2009，15，12：	12
	2	Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation显示文摘	Shafaqat Ali Dang Quan Nguyen Werner Falk Michael Uwe Martin	2009	Biochemical and Biophysical Research Communications2009，，3：	1
	3	Influence of natural killer cells and perforin-mediated cytolysis on the development of chemically induced lung cancer in A/J mice显示文摘	Manuela Frese-Schaper Andreas Keil Hideo Yagita Selina Katja Steiner Werner Falk Ralph Alexander Schmid Steffen Frese	2014	Cancer Immunology Immunotherapy2014，，6：	1
	4	Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn’s disease (CD) mucosa显示文摘	Julia Brenmoehl Markus Lang Martin Hausmann Sandra N. Leeb Werner Falk Jürgen Sch?lmerich Michael G?ke Gerhard Rogler	2007	International Journal of Colorectal Disease2007，，6：	1
	5	Cell-Cell Contacts Prevent Anoikis in Primary Human Colonic Epithelial Cells显示文摘	Claudia Hofmann Florian Obermeier Monika Artinger Martin Hausmann Werner Falk Juergen Schoelmerich Gerhard Rogler Johannes Grossmann	2007	Gastroenterology2007，，2：	1
	6	Inflammation modulates fibronectin isoform expression in colonic lamina propria fibroblasts (CLPF)显示文摘	Julia Brenmoehl Werner Falk Michael G?ke Jürgen Sch?lmerich Gerhard Rogler	2008	International Journal of Colorectal Disease2008，，10：	1
	7	EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells显示文摘	Julia Hoffmann Heike Junker Annett Schmieder Simone Venz Rowena Brandt Gabriele Multhoff Werner Falk Jürgen Radons	2011	Biochemical Pharmacology2011，，：	1
	8	N:P Ratio and the Nature of Nutrient Limitation in Calluna-Dominated Heathlands显示文摘	Goddert Oheimb Sally A. Power Kirsten Falk Uta Friedrich Abdelmenam Mohamed Angelika Krug Nora Boschatzke Werner H?rdtle	2010	Ecosystems2010，，2：	1

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