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| 1 | Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration显示文摘Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil(TEO) on hydrogen peroxide(H_2O_2)-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low(LD; 100 μmol/L) and high doses(HD;1 mmol/L) of H_2O_2 in the presence or absence of TEO(180 mg/kg). Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H_2O_2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO_2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H_2O_2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H_2O_2 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties. | Guesmi Fatma Amit K Tyagi Bellamine Houda Landoulsi Ahmed | 2016 | Biomedical and Environmental Sciences2016，29，9： | 3 |
| 2 | Transportation ontology definition and application for the content personalization of user interfaces显示文摘 | OLIVEIRA K M FIRAS B HOUDA M | 2013 | Expert systems with applications2013，40，3： | 1 |
| 3 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial_: responses to maternal metformin compared with insu- lin treatment? 显示文摘 | GATFORD K L HOUDA C M LU Z X | 2013 | Diab Obes Metab2013，15，7： | 1 |
| 4 | Genetic di- versity of Sulla genus (Hedysarea) and related species us- ing Inter-simple Sequence Repeat (ISSR) markers显示文摘 | Houda C K Marghali S Marrakehi M | 2007 | Bio- chem Syst Ecol2007，35，： | 1 |
| 5 | Heat Transfer Enhancement by Additive in Vertical Falling Film Absorption of H2O/LiBr 显示文摘 | Cheng W L Houda K Chen Z S | 2004 | Applied Thermal Engineering2004，24，23： | 1 |
| 6 | Heat transfer enhancement by additive in vertical falling film absorption of H2O/LiBr显示文摘 | CHENG W L HOUDA K CHEN Z S | 2004 | Appl Therm Eng2004，24，23： | 1 |
| 7 | Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis显示文摘Objective We evaluate the effects of Thymus algeriensis(TEO) against hydrogen peroxide(H2O2) toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats. Methods Rats were treated with low(LD) and high dose(HD) of H2O2(0.1 and 1 mmol/L) in the presence or absence of TEO(150 mg/kg). Results The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease(P<0.05), sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H2O2 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase(P<0.05) in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations. Conclusion H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats. | Fatma Guesmi Hamida Beghalem Amit K Tyagi Manel Ben Ali Ramla Ben Mouhoub Houda Bellamine Ahmed Landoulsi | 2016 | Biomedical and Environmental Sciences2016，29，4： | 0 |
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