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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 3 | Late Mesozoic metamorphic core complexes: new constraints on lithosphere thinning in North China显示文摘变形核心建筑群(mcc 的) 在岩石圈扩展的最突出的结构的式样之中并且在诺思中国在迟了的中生代期间变瘦。在这篇论文,几何,运动学并且 mcc 的一些的年龄特征例如 Liaonan, Waziyu (Yiwulshan ) , Yunmengshan,等等,被讨论。一些普通特征例如运动学的极性,几何不对称现象,在时间跨度上的出现,散布并且孤立分发,和进步开发,能在地区性的岩石圈扩展上提供直接限制并且在诺思中国变瘦,它不赞成占优势的羽毛模型,一个一般分层模型或前紧张的倒塌在变厚的 orogenic 上外壳。我们是那几个方面例如在在岩石圈期间,扩展和谭璐指责的深度的运动学的极性,当为岩石圈扩展构造一个更讲理的模型并且在诺思中国变瘦时,应该被考虑。 | LIU Junlai GUAN Huimei JI Mo HU Ling | 2006 | Progress in Natural Science:Materials International2006，16，6： | 38 |
| 4 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 5 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 6 | The Dayingzi detachment fault system in Liaodong Peninsula and its regional tectonic significance显示文摘Large scale lithosphere thinning is an important characteristic of the destruction of the North China Craton (NCC) during the late Mesozoic. A series of extensional structures were developed under extensional setting, among which is the Dayingzi detachment fault system (DFS). The DFS is constituted by three parts, volcano-sedimentary basins at the hanging wall, the Dayingzi-Huanghuadian detachment fault zone, and Paleoproterozoic metamorphic rock series and Mesozoic plutons at the foot-wall. In the section across the detachment fault zone, there is a sequence of tectonites including fault gouge, microbreccia, cataclastic-mylonites, mylonites, and gneissic biotite monzonite granite. Microstructural characteristics of tectonites and electron backscatter diffraction (EBSD) patterns of quartz indicate that the rocks from the footwall experienced a process from upper greenschist facies to lower greenschist facies. SHRIMP and LA-ICP MS U-Pb dating of zircons from the volcanic rocks in the basins, the tectonic evolution of the DFS is summarized as follows: 1) regional extension started at 135.0±1.2 Ma ago, when the detachment fault cut through the middle crust. Faulting induced the upwelling of magma and eruption of volcanic rocks and deformed a series of medium-acid volcanic rocks; 2) after 135.0±1.2 Ma, a large scale detachment faulting was active cross-cutting the mid-upper crust. The western margin of Jurassic and Triassic granite was ductilly and brittly sheared; besides, the Cretaceous volcano-sedimentary rocks were tilted when the master fault approached the surface; 3) at around 127±1 Ma, the detachment fault stopped its activity and was intruded by the unsheared Cretaceous granite near Chaoyang. Comparison with the Liaonan metamorphic core complex (MCC) and other extensional structures in Liaodong Peninsula led to a general trend of including three zones in the Peninsula: MCC zone, detachment fault systems (DFS) zone, and half graben zone. MCC commonly cuts through the mid-lower crust, DFS through the mid-upper crust, and half graben through the upper crust. Therefore, development of the extensional structures in Liaodong Peninsula indicates that they are the results of crustal extension and thinning at different crustal levels. They may provide a deep insight into the dynamic mechanism, history of destruction and lithosphere thinning of the North China Craton (NCC). | SHEN Liang LIU JunLai HU Ling JI Mo GUAN HuiMei Gregory A DAVIS | 2011 | Science China Earth Sciences2011，54，10： | 17 |
| 7 | Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis显示文摘Objective:To investigate the role of NLRP3 and NLRP1 inflammasomes signaling pathways in rheumatoid arthritis(RA).Methods:A total of 36 patients with RA were selected,peripheral blood mononuclear cell(PBMC)and granulocyte were separated from venous blood.RT-qPCR method was used to detect the expression level and diversity of NLRP3 and NLRP1 in PBMC and granulocyte mRNA in patieuts with RA.and detect the mRNA expression of downstream factor IL-1β.The correlation between RA and the expression of NLRP3 aud NLRP1 was analyzed.Normal 30 cases were set as control group.Results:Expression levels of NLRP1.and caspase-1mRNA in PBMC of RA group were significautly lower than those of control group(P<0.05).while there was no significant differeuee in expression levels of NLRP3,ASC.IL-1βmRNA between these two groups(P>0.05);NLRP3,caspase-1,and ASC mRNA expression in granulocyte of RA patients were significantly lower than those in control group(P<0.05).There was no currelation between rheumatoid factor and expression levels of NLRP3.ASC.caspase-1 mRNA in RA group(P>0.05);NLRP1,IL-1βmRNA expression level had a negative corrlation with anti-rheunatoid factor antibody(P=0.0332,0.0340).Conclusions:NLRP3 and NLRP1 inflammasomes signaling pathways are involved in RA inflammatory reaction process as protective factors,and play an important role in RA inflammatory mechanisms. | Tao Wang Chang-Liang Zhu Shuai Wang Li-Wen Mo Guo-Dong Yang Jun Hu Fan Zhang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，10： | 11 |
| 8 | Contributions of climate change and human activities to ET and GPP trends over North China Plain from 2000 to 2014显示文摘确定土壤水分蒸发蒸腾损失总量(et ) 和粗野主要生产率(GPP ) 改变的生态系统的气候变化和人的活动的贡献为改编评价和持续开发是重要的。et 和 GPP 的空间与时间的模式与一个物理、遥远的基于感觉的模型一起在诺思中国平原(NCP ) 上从 2000 ~ 2014 被估计。et 和 GPP 趋势的气候变化和人的活动的贡献被第一个差别趋势 de 方法和 multivariate 回归分开并且确定。结果显示出那年度 et , GPP 微弱地增加了,与气候变化和人的活动贡献 0.188 公里 yr-2 和 0.466 公里年-2到 0.654 公里年-2,的 et 趋势 and-1.321 g C m -2年-2和 7.542 g C m -2年-2到 GPP 6.221 的趋势 g C m -2年-2,分别地。在农田,增加的趋势主要在种舞台的小麦发生了;小麦和玉米的气候变化的贡献两个都是否定的。降水和阳光持续时间是调整 et 和 GPP 趋势的主要气候的因素。人的活动在 NCP 是到水消费和粗野主要生产率的长期的趋势的主要司机,这被结束。 | CHEN Xuejuan MO Xingguo HU Shi LIU Suxia | 2017 | Journal of Geographical Sciences2017，27，6： | 11 |
| 9 | Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats显示文摘Glucocorticoid (GC ) 导致了骨质疏松症(GIO ) 被损害骨头形成描绘,它能被 tanshinol 减轻,从鼠尾草植物 miltiorrhiza Bunge 孤立的水的多酚。在这研究,我们调查了位于成骨以及使用 tanshinol 防碍 GIO 的可能性的导致 GC 的调整下面的分子的机制。4 个月的女 SD 老鼠是口头上地管理的提取的水(反对) ,泼尼松(GC, 5 | Ya-jun YANG Zhu ZHU Dong-tao WANG Xin-le ZHANG Yu-yu LIU Wen-xiu LAI Yu-lin MO Jin LI Yan-long LIANG Zhuo-qing HU Yong-jie YU Liao CUI | 2018 | Acta Pharmacologica Sinica2018，39，4： | 11 |
| 10 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 11 | Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase显示文摘积聚的证据证明了一块地磁气的地的不利效果防护了状况因此打电话给一块 hypomagnetic 地(HMF ) ,在在动物和房间的新陈代谢的过程和氧化应力上。然而,内在的机制仍然保持不清楚。在这研究,我们在人的 neuroblastoma SH-SY5Y 房间在细胞的反应的氧种类(ROS ) 的规定上评估 HMF 的角色。我们发现 HMF 暴露导致了 ROS 减少,并且那恢复由另外的 H 2 O 2 救了提高 HMF 的房间增长。ROS 上的大小联系了索引,包括全部的抗氧化剂能力, H 2 O 2 和 superoxide 阴离子层次,和 superoxide dismutase (草皮) 活动和表示,显示 HMF 减少了 H 2 O 2 生产并且禁止了 CuZn 草皮的活动。而且, HMF 象 CuZn 草皮蛋白质的提高的聚集一样加速了 CuZn 草皮的变性作用,在 vitro。我们的调查结果显示 CuZn 草皮对对 HMF 压力的反应有能力并且建议它 HMF 效果的一个调停人。 | Hai-tao Zhang Zi-jian Zhang Wei-chuan Mo Ping-dong Hu Hai-min Ding Ying Liu Qian Hua Rong-qiao He | 2017 | Protein & Cell2017，8，7： | 10 |
| 12 | Effects of Boron on the Microstructure,Ductility-dip-cracking,and Tensile Properties for NiCrFe-7 Weld Metal显示文摘The distribution of boron and the microstructure of grain boundary(GB) precipitates(M_(23)(C,B)_6 and M_2B)have been analyzed with their effects on the susceptibility of ductility-dip-cracking(DDC) and tensile properties for NiCrFe-7 weld metal,using optical microscopy(OM),secondary ion mass spectroscopy(SIMS),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that boron segregates at GBs in NiCrFe-7 weld metal during the welding process.The segregation of boron at GBs promotes the formation of continuous M_(23)(C,B)_6 carbide chains and M_2B borides along GBs.The addition of boron aggravates GB embrittlement and causes more DDC in the weld metal,by its segregation at GBs presenting as an impurity,and promoting the formation of larger and continuous M_(23)(C,B)_6 carbides,and M_2B borides along GBs.DDC in the weld metal deteriorates the ductility and tensile strength of the weld metal simultaneously. | Wenlin Mo Xiaobing Hu Shanping Lu Dianzhong Li Yiyi Li | 2015 | Journal of Materials Science & Technology2015，31，12： | 9 |
| 13 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 14 | The Liaonan Metamorphic Core Complex: Constitution, Structure and Evolution显示文摘Liaonan 变形核心建筑群(mcc ) 有三层的结构并且被五部分组成,即在更低的板中的一个滑脱断层地区,在断层带上面的本土的上面的板和 ansupradetachment 盆,和高度变形的岩石和侵入岩。属曾被地壳动力搬的上面的板主要具有微弱地在 pre-Indosinan 舞台使变形并且变形的 Neoproterozoic 和古生代的岩石。在这些岩石上面是沉积的白垩纪和火山岩的 small-scalesupradetachment 盆。更低的板被太古代的 TTG 片麻岩与在上的次要的数量统治外壳的岩石。太古代的岩石被迟了的中生代 synkinematic monzogranitic 和花岗石的 plutons 侵入。差错岩石的不同类型,提供线索给滑脱断层地区的进化,在断层带是保存得很好的, e.g.mylonitic 片麻岩,糜棱岩,角砾岩晒糜棱岩,微角砾岩和 pseudotachylites。在更低的板中的线条花岗石的侵入有一致取向沿着主要滑脱断层地区显示一致 top-to-NWshearing。这也在更低的板中为花岗石的 plutons 的 synkinematiccharacteristics 提供证据。mcc 的那发掘由于外壳的块旋转并且正切的砍以地区性的外壳的扩展开始了的在 mcc 并且从从滑脱断层地区的岩石建议的更低的板和 mylonitic 的深成岩的同位素的标明日期的不同部分的结构的分析。延期触发了岩浆形成,在 welling 和炮兵阵地上面。以 pseudotachylite 和差错计量器的外观结束的这个事件形成了在最高外壳的水平。在更低的板中从花岗石的岩石单个锆石谷物标明日期的 U-Pb 给 130 + 的年龄 - 从主要滑脱断层地区的 5 妈,和 blotite 谷物有 Ar-^(39 ) Ar 108-119 变老的 ^(40 ) 妈。几个方面可以为 Liaonan mcc 的发掘提供限制。这些包括地区性的扩展一!设置,封面 / 地下室接触,时间、空间扩展和岩浆酌联合,盆开发和差错 tectonitesalong 的进化滑脱断层地区。我们建议 Liaonan mcc 的发掘源于地区性的扩展,高举并且在东方诺思中国,和花岗石的 plutons 的伴随的 withsynkieematic 侵入外壳或岩石圈变瘦,滑脱断层地区的形成并且降低板的岩石的发掘,和在上分开的外观盆。 | LIU Junlai GUAN Huimei JI Mo CAO Shuyun HU Ling | 2006 | Acta Geologica Sinica(English Edition)2006，80，4： | 8 |
| 15 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 16 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 17 | Inside-out Ostwald ripening: A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells显示文摘一灵巧在内外面,到 TiO 2 microspheres 的控制形态学的准备的 Ostwald 成熟线路被开发。这里, TiO 2 空 microspheres (HM ) 和稳固的 microspheres (SM ) 被在 solvothermal 过程以 acetylacetone (Acac ) 调整 isopropanol (国际语音学协会) 的体积比率准备。在 HM,稳固的核心的降水,核心的表面上的外部壳的随后的免职,和同时的核心的形成过程期间,溶解和壳再结晶被观察,它验证在内外面 Ostwald 成熟机制。TiO 2 microspheres 的性质(毛孔尺寸,表面区域,和陷井状态) 的设计和优化对 dyesensitized 太阳能电池(DSSC ) 的高效重要。优化 TiO 2 microspheres (rHM 和 rSM ) 在再结晶上由 processing 以后获得了,拥有大毛孔尺寸,高表面区域和减少的陷井状态(Ti 3+ 和氧空缺) ,并且因此是为光电的设备的理想的材料。用 rHM photoanode 制作的 DSSC 的力量变换效率是 11.22% ,它显著地与基于 rSM 的 DSSC 的 10.54% 效率相比被改进。我们的工作为综合提供策略 TiO 2 microspheres 同时提供不同物理性质以表面区域, crystallinity,形态学,和 mesoporosity。 | Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai | 2016 | Nano Research2016，9，7： | 7 |
| 18 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 19 | Recent Progress in Fiber-Optic Hydrophones显示文摘Fiber-optic hydrophone (FOH) is a significant type of acoustic sensor, which can be used in both military and civilian fields such as underwater target detection, oil and natural gas prospecting, and earthquake inspection. The recent progress of FOH is introduced from five aspects, including large-scale FOH array, very-low-frequency detection, fiber-optic vector hydrophone (FOVH), towed linear array, and deep-sea and long-haul transmission. The above five aspects indicate the future development trends in the FOH research field, and they also provide a guideline for the practical applications of FOH as well as its array. | Zhou MENG Wei CHEN Jianfei WANG Xiaoyang HU Mo CHEN Yichi ZHANG | 2021 | Photonic Sensors2021，11，1： | 6 |
| 20 | Impacts of climate change on agricultural water resources and adaptation on the North China Plain显示文摘气候变化在北方中国平原(NCP ) 上为农业生产在水资源的可获得性上正在有可观的影响,在自从 1950 年代,水的缺乏当前关于弄干的趋势正在扰乱农业生产的稳定性和可持续性的地方。然而,尽管潜在的土壤水分蒸发蒸腾损失总量(et ) 在气候变化下面显示出一个减少的趋势,实际 et 稍微在水文学骑车与加速增加了。全球气候模型(GCM ) 整体设计由源于全球温暖的 2050 年代,增加的庄稼水需求和加强的 et 预言那将关于 4%-24% 减少水资源剩余(降水 et ) 并且显著地在庄稼生长时期增加灌溉水需求。这研究为创新农业可持续性估计可能的缓解和改编措施。它被表明那减少在水有限盆的冬季小麦(3.0%-15.9%) 的播种区域,和在庄稼水使用的改进,效率将有效地减轻水缺乏并且加强农业系统的跳回到气候变化。 | MO Xing-Guo HU Shi LIN Zhong-Hui LIU Su-Xia XIA Jun | 2017 | Advances in Climate Change Research2017，8，2： | 6 |
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