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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | The discovery of the oldest rocks in the Kuluketage area and its geological implications显示文摘The basement rocks in the Kuluketage area are composed predominately of tonalite-trondhjemite-granodiorite rocks, and occured mainly in Xinger and Korla. U-Pb dating of TTG gneiss near Korla yielded a late Neoarchean weighted mean 207Pb/206Pb age of 2.65 Ga, which is the oldest published age for the TTG rocks in the Kuluketage area and thus suggests that Archean terrane in the area was formed in the late Neoarchean. The Korla gneiss is much younger than the TTG rocks in the northern Altyn Tagh, eastern Tarim Craton, indicating that the oldest terrane of the Tarim Craton was exposed probably in the northern Altyn Tagh. Until late Neoarchean, the Tarim continent extends to the Kuluketage area and finally had generated a relatively large uniform Archean basement within the craton. Zircon Hf isotopic analyses of the TTG gneiss give low εHf(t) values (-5 to 1) with Paleoarchean to Mesoarchean two-stage model ages (TDM2) between 3.0 and 3.3 Ga, suggesting that the basement rocks in the northern Tarim Craton were derived dominately from partial melting of Paleoarchean to Mesoarchean juvenile crustal material. The Hf model ages, therefore, indicate that no continent crust older than 3.3 Ga existed in the Kuluketage area. | LONG XiaoPing YUAN Chao SUN Min XIAO WenJiao ZHAO GuoChun ZHOU KeFa WANG YuJing HU AiQin | 2011 | Science China Earth Sciences2011，54，3： | 16 |
| 3 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 4 | Holocene aeolian stratigraphic sequences in the eastern portion of the desert belt(sand seas and sandy lands) in northern China and their palaeoenvironmental implications显示文摘This paper presents the environmental history and its responses to palaeoclimatic changes since the start of the Holocene in the eastern portion of the desert belt(sand seas and sandy lands) in northern China by comparing the aeolian sandpalaeosol sequences and their palaeoclimatic proxies. The optically stimulated luminescence(OSL) ages of the aeolian sandpalaeosol sedimentary sequences and a series of palaeoenvironmental proxies show that:(1) The large-scale dune landscape currently in the Kubuqi Sand Sea was formed during the Holocene in general;and the palaeosol was generally developed during the period of 4–2 ka, indicating conditions favorable for vegetation growth, soil development, and organic carbon accumulation due to increased precipitation or effective moisture and weakened aeolian activities;the large-scale expansion of dunes in the recent 2 ka is closely linked to human activities. The variable discharge of the Yellow River with diversions for irrigation may have resulted in a more consistent supply of aeolian particles for dune field expansion.(2) The dune landscape of the Hunshandake Sandy Land was likely formed around 12 ka, and before this, the western part of the Hunshandake Sandy Land would have been covered by a single large lake;it was obviously wetter than today in the sandy land during the period of 9.6–3 ka and the palaeosols were developed at the same time. But the aeolian activities have not been completely dormant in this long-lasting wetter epoch;because the Holocene wetter period was likely time-transgressive across the region.(3) The palaeosol of the Hulunbuir Sandy Land began to develop as early as 14.5 ka, probably continuing until the last 2 ka. The palaeosol development of various dune fields in the eastern portion of the desert belt(sand seas and sandy lands) in northern China is spatially heterogeneous, and even the palaeosol development time in different locations within each sandy land is inconsistent. During the middle Holocene(especially the 7.5–3.5 ka), all the sandy lands were stabilized in general and the intensity of aeolian activities was significantly weakened. The number of palaeoenvironmental records in the eastern portion of the desert belt(sand seas and sandy lands) in northern China has increased rapidly in the past decade, but the amount of published data still does not match the vast extent of the dune fields. It does require much more in-depth palaeoenvironmental studies for a full understanding of the relationship between aeolian activities and climate change in northern China. | Xiaoping YANG Peng LIANG Deguo ZHANG Hongwei LI Patrick RIOUAL Xulong WANG Bing XU Zhibang MA Qianqian LIU Xiaozong REN Fangen HU Yuxin HE Gang RAO Ninghua CHEN | 2019 | Science China Earth Sciences2019，62，8： | 10 |
| 5 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 6 | Cu Partitioning Behavior and Its Effect on Microstructure and Mechanical Properties of 0.12C-1.33Mn-0.55Cu Q&P Steel显示文摘Cu, as an austenitic stable element, is added to steel in order to suppress the adverse effects of high content of C and Mn on welding. Based on C partitioning, Cu and Mn partitioning can further improve the stability of retained austenite in the intercritical annealing process. A sample of low carbon steel containing Cu was treated by the intercritical annealing, then quenching process(I&Q). Subsequently, another sample was treated by the intercritical annealing, subsequent austenitizing, then quenching and partitioning process(I&Q&P). The effects of element partitioning behavior in intercritical region on the microstructure and mechanical properties of the steel were studied. The results showed that after the I&Q process ferrite and martensite could be obtained, with C, Cu and Mn enriched in the martensite. When intercritically heated at 800 ℃, Cu and Mn were partitioned from ferrite to austenite, which was enhanced gradually as the heating time was increased. This partitioning effect was the most obvious when the sample was heated at 800 ℃ for 40 min. At the early stage of α→γ transformation, the formation of γ was controlled by the partitioning of carbon, while at the later stage, it was mainly affected by the partitioning of Cu and Mn. After the I&Q&P process, the partitioning effect of Cu and Mn element could be retained. C was assembled in retained austenite during the quenching and partitioning process. The strength and elongation of I&Q&P steel was increased by 5 305 MPa% compared with that subjected to Q&P process. The volume fraction of retained autensite was increased from 8.5% to 11.2%. Hence, the content of retained austenite could be improved significantly by Mn and Cu partitioning, which increased the elongation of steel. | 陈连生 HU Baojia XU Jinghui 田亚强 ZHENG Xiaoping SONG Jinying XU Yong | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 6 |
| 7 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 8 | Tidal stress triggering effects of earthquakes based on various tectonic regions in China and related astronomical characteristics显示文摘Dividing the China's Mainland into different tectonic stress regions,we calculate tidal stress components along the seismic compressive and extensional principal stress axes at every earthquake's focus in different tectonic stress regions.Tidal stress triggering effect on every earthquake fault is analyzed.Based on this,the lunar-solar location parameters on the occurring times of earthquakes which suffered tidal triggering effects are calculated,and the distribution patterns of the lunar-solar location parameters in different tectonic stress regions are obtained.The results indicate that earthquake tidal triggering effects and related astronomical characteristics are dependent on the properties of regional tectonic stress and the geographic locations of earthquake faults. | WU XiaoPing MAO Wei HUANG Yong HU Hui HU YiLi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 6 |
| 9 | New Record of Palaeoscolecids from the Early Cambrian of Yunnan,China显示文摘摘要:新 palaeoscolecid, Guanduscolex 次要的胡,罗 et Fu 情报。et sp。nov,与内向的人和肠的保存软部分来自云南的更低的寒武纪的 Guanshan 动物志,华南。扫描电子显微镜学(SEM ) 揭示的表皮的微结构细节证明每个环忍受三排盘子,每个盘子忍受 910 边缘并且 45 个中央节点。这发现在关系和 palaeoscolecids 和另外的早 priapulids 的进化小径上打开新灯。 | HU Shixue LI Yong LUO Huilin FU Xiaoping YOU Ting PANG Jiyuan LIU Qi Michael STEINER | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 10 | Effect of Holding Time on Thixotropic Fluidity of Semi-solid AZ91D Magnesium Alloy显示文摘在再热期间调查半固体 AZ91D 镁合金的 thixotropic 流动性,微观结构和 mechanicalproperties ,白手起家的死有隧道 ofdifferent 尺寸的集合是批评形成强迫的 used.The 结果表演,最大的形成 forcescould 被获得并且与在半固体的成立时间有关形成 process.In 0-2700 s 的 holdingtime ,与增加成立时间,最大的形成力量严厉地减少了形成力量的 andcritical 减少了 slowly.In | Zesheng JI Maoliang HU Xiaoping ZHENG | 2007 | Journal of Materials Science & Technology2007，23，2： | 6 |
| 11 | Analysis on Dam-Breaking Mode of Tangjiashan Barrier Dam in Beichuan County显示文摘Tangjiashan landslide is a typical high-speed consequent landslide of medium-steep dip angle. This landslide triggered by earthquake took place in about semi-minute. The relative sliding displacement is 900 meters, so average sliding speed is about 30 meters per second. The longitudinal length of barrier dam which is formed by high-speed landslide along river is 803.4 meters; and maximum width crossing river is 611.8 meters. And its volume is estimated about 20.37 million steres. Through detailed geological investigation of the barrier dam, together with early geological information before earthquake, geological structures of the barrier dam and its stability of upstream and downstream slopes are studied when water level reaches different elevations in condition of continual after shocks with seismic intensity of 7 or 8 Richter scale. On this basis, dam-breaking mode of barrier dam is discussed deeply. Thereby, analytic results provide significant guidance and advices to front headquarters of Tangjiashan barrier dam, so that some proper engineering measures can be implemented and flood discharge can be carried out well. | HU Xiewen LUO Gang LV Xiaoping HUANG Runqiu SHI Yubin | 2011 | Journal of Mountain Science2011，8，2： | 6 |
| 12 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 13 | Transgene directionally integrated into C-genome of Brassica napus显示文摘Integration of a transgene into a C-genome chromosome plays an important role in reducing ecological risk of transgenic Brassica napus To obtain C-genome transgenic B. napus, herbi- cide-resistant bar gene was firstly transferred into B. oleracea var. alboglabra mediated by Agrobacterium tumefaciens strain LBA4404. Then using the trans- genic B. oleracea as paternal plants and 8 non- transgenic varieties of B. rapa as maternal plants, C- genome transgenic B. napus with bar gene was arti- ficially resynthesized by means of ovary culture and chromosome doubling. Among 67 lines of the resyn- thesized B. napus, 31 were positive, and 36 were negative according to PCR test for bar gene. At least 2 plants from each line were kept for PPT spray con- firmation. The result was in consistence with the PCR test. Genomic Southern blotting of three randomly chosen lines also showed that bar gene had been integrated into the genome of resynthesized B. napus lines. | LI Jun FANG Xiaoping WANG Zhuan LUO Lixia HU Qiong | 2006 | Chinese Science Bulletin2006，51，13： | 5 |
| 14 | A New Arthropod,Guangweicaris Luo,Fu et Hu gen. nov. from the Early Cambrian Guanshan Fauna,Kunming,China显示文摘The Guanshan Fauna is a soft-bodied fauna dominated by arthropods (including trilobites, trilobitoides, Tuzoia, Isoxys, and bradorids) in association with priapulids, brachiopods, anomalocaridids, vetulicoliids, sponges, chancellorids, and echinoderms. This paper reports and describes a new arthropod from the yellowish green mudstone at the lower part of the Wulongqing Formation, Canglangpuan Stage, Lower Cambrian in Kunming, Yunnan, China. The stratigraphic and geographic distribution, classification, fossil preservation, life style of this new arthropod and comparisons with other fossil arthropods are also discussed in details. The discovery and research of the non-mineralized arthropod, Guangweicaris Luo, Fu et Hu gen. nov. from the Guanshan Fauna adds new members to the taxonomic list and provides new information to the evolution of early arthropods. Furthermore, this study would shed new light into the “Cambrian Explosion” and the evolution of early life. | LUO Huilin FU Xiaoping HU Shixue LI Yong HOU Shuguang YOU Ting PANG Jiyuan LIU Qi | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 5 |
| 15 | TiO_2-coated SnO_2 hollow spheres as anode materials for lithium ion batteries显示文摘TiO2-coated SnO2(TCS) hollow spheres,which are new anode materials for lithium ion(Li-ion) batteries,were prepared and characterized with X-ray diffraction(XRD) ,scanning electron microscopy(SEM) ,transmission electron microscopy(TEM) ,cyclic voltammetry(CV) ,and galvanostatic charge/discharge tests.The results obtained from XRD,SEM,and TEM show that TiO2 can be uniformly coated on the surface of SnO2 hollow spheres with the assistance of anionic surfactant.The cyclic voltammograms indicate that both TiO2 and SnO2 ex-hibit the activity for Li-ion storage.The charge/discharge tests show that the prepared TCS hollow spheres have a higher reversible coulomb efficiency and a better cycling stability than the uncoated SnO2 hollow spheres. | YI Jin LI Xiaoping HU Shejun LI Weishan ZENG Ronghua FU Zhao CHEN Lang | 2011 | Rare Metals2011，30，6： | 4 |
| 16 | Per os infectivity factors:a complicated and evolutionarily conserved entry machinery of baculovirus显示文摘Baculoviruses are a family of arthropod-specific large DNA viruses that infect insect species belonging to the orders Lepidoptera,Hymenoptera and Diptera.In nature,occlusion-derived viruses(ODVs) initiate baculovirus primary infection in the midgut epithelium of insect hosts,and this process is largely dependent on a number of ODV envelope proteins designated as per os infectivity factors(PIFs).Interestingly,PIF homologs are also present in other invertebrate large DNA viruses,which is indicative that per os infection is an ancient and phylogenetically conserved entry mechanism shared by these viruses.Here,we review the advances in the knowledge of the functions of individual PIFs and recent discoveries about the PIF complex,and discuss the evolutionary implications of PIF homologs in invertebrate DNA viruses.Furthermore,future research highlights on the per os infection mechanism are also prospected. | Xi Wang Xiaoping Liu George Alliwa Makalliwa Jiang Li Hualin Wang Zhihong Hu Manli Wang | 2017 | Science China(Life Sciences)2017，60，8： | 4 |
| 17 | The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases显示文摘Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive decline,accompanied by amyloid-β(Aβ)overload and hyperphosphorylated tau accumulation in the brain.Synaptic dysfunction,an important pathological hallmark in AD;is recognized as the main cause of the cognitive impairments.Accumulating evidence suggests that synaptic dysfunction could be an early pathological event in AD.Pathological tau,which is detached from axonal microtubules and mislocalized into pre-and postsynaptic neuronal compartments,is suggested to induce synaptic dysfunction in several ways,including reducing mobility and release of presynaptic vesicles,decreasing glutamatergic receptors,impairing the maturation of dendritic spines at postsynaptic terminals,disrupting mitochondrial transport and function in synapses,and promoting the phagocytosis of synapses by microglia.Here,we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in AD.We propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD. | Moxin Wu Manqing Zhang Xiaoping Yin Kai Chen Zhijian Hu Qin Zhou Xianming Cao Zhiying Chen Dan Liu | 2021 | Translational Neurodegeneration2021，10，4： | 4 |
| 18 | A qualitative study on nurses'reactions to inpatient suicide in a general hospital显示文摘Aims:To explore the impact of inpatient suicides on nurses working in front-line,the patterns of regulation and their needs for support.Methods:Data were collected through purposive sampling by conducting semi-structured and individual in-depth interviews in a tertiary referral hospital in China.Colaizzi's sevenstep phenomenological method was simultaneously used by two interviewers.Results:Reactions to inpatient suicides revealed three central themes:(1)inpatients were highly likely to commit suicide,(2)inpatient suicide was difficult to prevent,and(3)nurses lacked the necessary suicide prevention skills.Psychological responses mainly included shock and panic,self-accusation or guilt,sense of fear,and frustration.The impacts on practice were stress,excessive vigilance,and burnout.Avoidance and sharing of feelings played key roles in the regulation patterns of nurses.Conclusions:Nurses who experienced inpatient suicide became stressed.Effective interventions must be implemented to improve the coping mechanisms of nurses against the negative consequences of inpatient suicide.The findings of this study will allow administrators to gain insight into the impacts of inpatient suicides on nurses in general hospitals.Such information can be used to develop effective strategies and provide individual support and ongoing education.Consequently,nurses will acquire suicide prevention skills and help patients achieve swift recovery. | Shujie Wang Xiaoping Ding Deying Hu Keke Zhang Di Huang | 2016 | International Journal of Nursing Sciences2016，3，4： | 4 |
| 19 | Application Value of Topical Aneasthesia in Children Strabismus Surgery显示文摘Purpose:Comparison of topical vs general aneasthesia for strabismus surgery. Methods: Preoperative patients (aged 6~12 years) were divided into two study groups: the topical aneasthesia group (n=22), and the general aneasthesia group (n=21). The study groups were compared on the following measures:.analgesic effect, surgical correction effect, eye-heart reflex, preoperative preparation time. and operation time, using t-tests or X2 tests where appropriate. Results:.Compared with the general aneasthesia group, the topical aneasthesia group gained better surgical correction results(P<0.05), had a lower rate of eye-heart reflex (P<0.05), and had a shorter preoperative preparation time (P<0.001). No significant difference was observed between the groups in terms of the analgesic effect or operation time (P>0.05). Conclusion:Topical aneasthesia represents a safe and effective alternative to general aneasthesia for strabismus surgery in children. | Xiaoping He Lina Chen Xinfu Pan Huiyong Hu Zhimin Shi | 2012 | Eye Science2012，27，3： | 3 |
| 20 | Enhancement of memory function in aged mice by a novel derivative of xanomeline显示文摘 | Yihui Cui Dong Wang Wen Si Wen Lv Yan Niu Xiaoping Lei Yinhe Hu Xiaohua Cao | 2008 | Cell Research2008，18，11： | 3 |
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