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1篇 您的检索式：作者名="HUFFMAN Justin"

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		题名	作者	年代	出处	被引量
	1	Biosynthesis and Genetic Engineering of Polyketides显示文摘Polyketides are one of the largest groups of natural products produced by bacteria, fungi, and plants. Many of these metabolites have highly complex chemical structures and very important biological activities, including antibiotic, anticancer, immunosuppressant, and anti-cholesterol activities. In the past two decades, extensive investigations have been carried out to understand the molecular mechanisms for polyketide biosynthesis. These efforts have led to the development of various rational approaches toward engineered biosynthesis of new polyketides. More recently, the research efforts have shifted to the elucidation of the three-dimentional structure of the complex enzyme machineries for polyketide biosynthesis and to the exploitation of new sources for polyketide production, such as filamentous fungi and marine microorganisms. This review summarizes our general understanding of the biosynthetic mechanisms and the progress in engineered biosynthesis of polyketides.	ZHU Xiang-Cheng HUFFMAN Justin GERBER Ryan LOU Li-Li XIE Yun-Xuan LIN Ting JORGENSON Joel MARESCH Andrew VOGELER Chad WANG Qiao-Mei SHEN Yue-Mao DU Liang-Cheng	2008	云南植物研究2008，30，3：	1

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