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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Some electromagnetic aspects of coreless PCB transformers显示文摘 | TANG S C HUI S Y CHUNG Henry-hung | 2000 | IEEE Trans on power electronics2000，15，4： | 2 |
| 3 | Removal of mixed heavy metal ions in wastewater by zeolite 4A and residual products from recycled coal fly ash 显示文摘 | Hui K S Chao C Y H Kot S C | 2005 | Journal of Hazardous Materials2005，127，13： | 1 |
| 4 | Discrete transform technique for sol- ving coupled integro- differential equations in digital computers 显示文摘 | S Y R HUI C Christopoulos | 1991 | IEEE PROCEEDINGS - A1991，138，5： | 1 |
| 5 | Reduction of Power Converter EMI Emission Using Soft-Switching Technique显示文摘 | Chung H Hui S Y R Tse K K | 1998 | IEEE Transaction on Electromagnetic Compatibility1998，40，3： | 1 |
| 6 | Synthesis of three diosgenyl saponins:dioscin polyphyllin D,and balanitin 7显示文摘 | DENG S J YU B HUI Y Z | 1999 | Carbohydrate Research1999，317，： | 1 |
| 7 | Separation and determination of β - agonists in serum by capillary zone electrophoresis with amperometric detection 显示文摘 | T S Zhou H Qin Y Z Hui | 2001 | Analytica Chimica Acta2001，441，： | 1 |
| 8 | Effects of step - change of synthesis temperature on synthesis of zeolite 4A from coal fly ash 显示文摘 | HUI K S CHAO C Y H | 2006 | Microporous and Mesoporous Materials2006，88，2： | 1 |
| 9 | Analysis and Spectral characteristics of a spread-spectrum technique for conducted EMI suppression显示文摘 | Tse K K Chung H Hui S Y R So H C | 2000 | IEEE Trans on Power Electronics2000，15，： | 1 |
| 10 | Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality显示文摘 | Hui L Yao Y Wang S | 2009 | J Trauma2009，66，3： | 1 |
| 11 | A zero-cur- rent-switching PWM flyback converter with a simple auxiliary switch 显示文摘 | CHUNG Henry S H HUI S Y and WANG Weihua | 1999 | IEEE Transactions on Power Electronics1999，14，2： | 1 |
| 12 | Analysis and spectral characteristics of a spread spectrum technique for conducted EMI suppression 显示文摘 | TSE K K CHUNG H S H HUI S Y R | 2000 | IEEE Transactions on Power Electronics2000，15，2： | 1 |
| 13 | A simple method for comparative study on the thermal performance of LEDs and fluorescent lamps显示文摘 | Qin Ya-xiao Lin De-yan Hui S Y | 2009 | IEEE Transactions on Power E-lectronics2009，24，7： | 1 |
| 14 | Removal of mixed heavy metal ions in waste water by zeolite 4A and residual products from recycled coal fly ash显示文摘 | Hui K S Chao C Y H Kot S C | | Journal of Hazardous Materials0，127，123： | 1 |
| 15 | Mining a web citation database for document clustering 显示文摘 | HE Y HUI S C FONG A C M | 2002 | Applied Artificial Intelligence2002，16，： | 1 |
| 16 | Coreless printed circuit board(PCB) transformers with multiple secondary windings for complementary gate drive circuits显示文摘 | Hui S Y R Chung H | 1999 | IEEE Transactions on Power Electronics1999，14，3： | 1 |
| 17 | An Evaluation of the spectral Characteristics of Switching Converters with Chaotic Carrier-Frequency Modulation显示文摘 | Tse K K Ng R W M Chung H Hui S Y R | 2003 | IEEE Trans on Industrial Electronics2003，50，1： | 1 |
| 18 | Optimal design of a hybrid winding structure for planar battery charging platform显示文摘 | Liu X Hui S Y | 2008 | IEEE Transactions on Power Electronics2008，23，1： | 1 |
| 19 | A comparative investigation on the use of random modulation schemes for DC/DC converters显示文摘 | TSEN K CHUNG H S H HUI S Y R | 2000 | IEEE Transactions on Industrial Electronics2000，47，2： | 1 |
| 20 | Removal of mixed heavy metal ions in wastewater by zeolite 4A and residual products from recycled coal fly ash 显示文摘 | Hui K S Chao C Y H Kot S C | 2005 | Journal of Hazardous Materials2005，127，13： | 1 |
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