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| 1 | A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer显示文摘AIM: To prospectively compare volumetric intensitymodulated arc therapy(VMAT) and conventional intensity-modulated radiation therapy(IMRT) in coverage of planning target volumes and avoidance of multiple organs at risk(OARs) in patients undergoing definitive chemoradiotherapy for advanced(stage Ⅲ or Ⅳ)squamous cell cancer of the head and neck. METHODS: Computed tomography scans of 20 patients with advanced tumors of the larynx, naso-, oroand hypopharynx were prospectively planned using IMRT(7 field) and VMAT using two arcs. Calculated doses to planning target volume(PTV) and OAR were compared between IMRT and VMAT plans. Dose-volume histograms(DVH) were utilized to obtain calculated doses to PTV and OAR, including parotids, cochlea,spinal cord, brainstem, anterior tongue, pituitary and brachial plexus. DVH's for all structures were compared between IMRT and VMAT plans. In addition the planswere compared for dose conformity and homogeneity. The final treatment plan was chosen by the treating radiation oncologist. RESULTS: VMAT was chosen as the ultimate plan in 18 of 20 patients(90%) because the plans were thought to be otherwise clinically equivalent. The IMRT plan was chosen in 2 of 20 patients because the VMAT plan produced concentric irradiation of the cord which was not overcome even with an avoidance structure. For all patients, VMAT plans had a lower number of average monitor units on average(MU = 542.85) than IMRT plans(MU = 1612.58)(P < 0.001). Using the conformity index(CI), defined as the 95% isodose volume divided by the PTV, the IMRT plan was more conformal with a lower conformity index(CI = 1.61) than the VMAT plan(CI = 2.00)(P = 0.003). Dose homogeneity, as measured by average standard deviation of dose distribution over the PTV, was not different with VMAT(1.45 Gy) or IMRT(1.73 Gy)(P = 0.069). There were no differences in sparing organs at risk.CONCLUSION: In this prospective study, VMAT plans were chosen over IMRT 90% of the time. Compared to IMRT, VMAT plans used only one third of the MUs, had shorter treatment times, and similar sparing of OAR. Overall, VMAT provided similar dose homogeneity but less conformity in PTV irradiation compared to IMRT. This difference in conformity was not clinically significant. | Simon D Fung-Kee-Fung Rachel Hackett Lee Hales Graham Warren Anurag K Singh | 2012 | World Journal of Clinical Oncology2012，3，4： | 2 |
| 2 | Leader-member Exchange As A Mediator of the Relationship be- tween Transformational Leadership and Followers' Performance and Organizational Citizenship Behavior显示文摘 | WANG H LAW K S HACKETT R D WANG D CHEN Z X | 2005 | The Academy of Man- agement Journal2005，48，3： | 1 |
| 3 | Stations, Trains and Small-world Networks显示文摘 | Seaton K Hackett L | 2004 | Physica A2004，339，3： | 1 |
| 4 | Stations, trains and small-world networks 显示文摘 | Seaton K A Hackett L M | 2004 | Physica A: Statistical Mechanics and Its Applications2004，339，34： | 1 |
| 5 | Leader-member Echange as a Mediator of the Relationship Between Transformational Leadership and Followers' Performance and Organizational Citizenship Behavior显示文摘 | Law K S Hackett R D Wang D Chen Z | 2005 | Academy of Management Journal2005，，3： | 1 |
| 6 | Stations, Trains and Small-world Network 显示文摘 | Seaton K Hackett L | 2004 | Physica A2004，339，3： | 1 |
| 7 | Adenoviral vector-mediated gene transfer to primitive human hematopoietic progenitor cells:asessment of transduction and toxicity in long-term culture显示文摘 | MACKENZIE K L HACKETT N R CRYSTAL R G | 2000 | Blood2000，96，1： | 1 |
| 8 | Free radical scavengerscatalase and superoxide dismutase provide pro- tection from oxalate- associated injury to LLC -PK1 and MDCK cells显示文摘 | THAMILSELVAN S BYER K J HACKETT R L | 2000 | J Urol2000，164，1： | 1 |
| 9 | Molecular Reconstruction of Sleeping Beauty , a Tc1 -like Transposon from Fish, and Its Transposition in Human Cells显示文摘 | Zoltán Ivics Perry B Hackett Ronald H Plasterk Zsuzsanna Izsvák | 1997 | Cell1997，，4： | 1 |
| 10 | Creating a buzz about insect genomes显示文摘 | ROBINSON G E HACKETT K J PURCELL M M | 2011 | Science2011，331，6023： | 1 |
| 11 | Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogesis in non- ischemic tissre by a constitutively active form of hypoxia-inducible factor 1 显示文摘 | Kelly BD Hackett SF Hirota K | 2003 | Circ Res2003，93，： | 1 |
| 12 | Radiofrequency catheter ablation of ventricular tachyea-rdia in patients without structural heart disease显示文摘 | KLEIN L S SHIH H T HACKETT F K | 1992 | Circulation1992，85，： | 1 |
| 13 | Station, trains and small-world networks显示文摘 | Seaton K A Hackett L M | 2004 | Physical A2004，339，34： | 1 |
| 14 | Radiofrequency catheter ablation of ventricular tachycardia in patients without structure heart disease显示文摘 | Klein LS Hue-Teh Hackett K | 1992 | Circulation1992，85，： | 1 |
| 15 | Potassium dichromate induced cytotoxicity, genotoxicity and oxidative stress in human liver carcinoma ( HepG2 ) ceils 显示文摘 | Patlolla K Barnes C Hackett D | 2009 | Int J Environ Res Public Health2009，，6： | 1 |
| 16 | The population pharmacokinetics of citalopram after deliberate self-poisoning :a baysian approach显示文摘 | Friberg L E Isbister G K Hackett L P Duffull S B | 2005 | Journal of Pharmacokinetics and Biopharmaceutics2005，32，34： | 1 |
| 17 | A cardioactive peptide from the souther armyworm, Spodoptera eridania显示文摘 | Furuya K Hackett M Cirelli MA etal | 1999 | Peptide1999，20，： | 1 |
| 18 | Characteristics of Steam Hydrogasification of Wood Using a Micro-Batch Reactor 显示文摘 | Jeon S K Park C S Hackett C E | 2007 | Fuel2007，86，1718： | 1 |
| 19 | Ratioimaging of Ca^2+ in the self-incompatibility response in pollen tubes of Papaver rhoeas 显示文摘 | Franklin-Tong V E Hackett G Hepler P K | 1997 | Plant J1997，12，： | 1 |
| 20 | Characteristics of Steam Hydrogasification of Wood Using a Micro-Batch Reactor 显示文摘 | Jeon S K Park C S Hackett C E | 2007 | Fuel2007，86，1718： | 1 |
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