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| 1 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 2 | Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis显示文摘OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients. | Jian Liu Yunxiang Cao Chuanbing Huang Yuan Wang Xi Chen Wandong Zhang Guizhen Wang Haixia Fan Yao Ge Ruilian Chen Ruikai Zong Yajun Qi Yue Sun Yifei Liu Fang Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 3 | A Survey of Mobile Cloud Computing显示文摘Mobile Cloud Computing (MCC) is emerging as one of the most important branches of cloud computing. In this paper, MCC is defined as cloud computing extended by mobility, and a new ad-hoc infrastructure based on mobile devices. It provides mobile users with data storage and processing services on a cloud computing platform. Because mobile cloud computing is still in its infancy, we aim to clarify confusion that has arisen from different views. Existing works are reviewed, and an overview of recent advances in mobile cloud computing is provided. We investigate representative infrastructures of mobile cloud computing and analyze key components. Moreover, emerging MCC models and services are discussed, and challenging issues are identified that will need to be addressed in future work. | Xiaopeng Fan Jiannong Cao Haixia Mao | 2011 | ZTE Communications2011，9，1： | 7 |
| 4 | Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China显示文摘Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose metabolism in the first pregnancy to the recurrence of GDM and the development of DM.There are significant differences in OGTT levels of the first pregnancy such as area under the curve of OGTT value(18.31±1.90 mmol/L vs.16.27±1.93 mmol/L vs.15.55±1.92 mmol/L,P<0.001),OGTT fasting value(5.43±0.48 mmol/L vs.5.16±0.49 mmol/L vs.5.02±0.47 mmol/L,P<0.001),OGTT 1-hour value(10.93±1.34 mmol/L vs.9.69±1.53 mmol/L vs.9.15±1.58 mmol/L,P<0.001),OGTT 2-hour value(9.30±1.66 mmol/L vs.8.01±1.32 mmol/L vs.7.79±1.38 mmol/L,P<0.001),incidence of impaired fasting glucose(IFG)(fasting plasma glucose≥5.6 mmol/L)(31.3%vs.14.6%vs.8.8%,P<0.001),and incidence of two or more abnormal OGTT values(68.8%vs.39.7%vs.23.9%,P<0.001)among the three groups.Using multivariate analysis,the factors,such as age(1.07[1.02-1.12],P=0.006),prepregnancy BMI(1.07[1.02,1.12],P=0.003),and area under the curve of OGTT in the first pregnancy(1.14[1.02,1.26],P=0.02),have an effect on maternal GDM recurrence;the factors,such as age(1.28[1.01-1.61],P=0.04),pre-pregnancy BMI(1.26[1.04,1.53],P=0.02),and area under the curve of OGTT in the first pregnancy(1.65[1.04,2.62],P=0.03),have an effect on maternal DM developed further.Conclusions:The history of GDM was significantly associated with a higher maternal risk for GDM recurrence during follow-up after the first pregnancy.The associated risk factors for GDM recurrence or development of DM include age,high pre-pregnancy BMI,history of delivered macrosomia,the OGTT level in the first pregnancy,such as the high area under the curve of OGTT,IFG,and two or more abnormal OGTT values.To prevent GDM recurrence,women with a history of GDM should do the preconception counseling before preparing next pregnancy. | Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang | 2022 | Chinese Medical Journal2022，，6： | 7 |
| 5 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 6 | Changes in wind activity from 1957 to 2011 and their possible influence on aeolian desertification in northern China显示文摘Wind activity is proved to have significant impacts on aeolian desertification. Clarifying the fluctuations and change trend of wind velocity is important for understanding their influence on aeolian desertification. In this study, we used a dataset of wind velocities collected from 93 meteorological stations across northern China from 1957 to 2011 to analyze the changes in wind activity during this period. We tested the monotonic and step(abrupt) trends for annual and seasonal data of mean wind velocity by using Mann-Kendall and Mann-Whitney tests, respectively. The results indicated that the annual mean wind velocity decreased by 0.83 m/s from 1957 to 2011. The decreasing trends were also significant(P<0.01) for each season. The magnitude of the decrease was smallest in the east of northern China and largest in the west of northern China, and the most remarkable decrease occurred in the northwest of northern China. Abrupt decreases in annual and seasonal mean wind velocities occurred in the mid-1980 s, which was consistent with the changes in aeolian desertification since the mid-1980 s in northern China. As revealed by our study, although both modern aeolian desertification and ecosystem rehabilitation are affected by human activities to some extent, they are also likely to be strongly controlled by climate change, especially by wind activity. | LI Jinchang LIU Haixia SU Zhizhu FAN Xiaohui | 2015 | Journal of Arid Land2015，7，6： | 4 |
| 7 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 8 | A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants显示文摘Zinc(Zn)alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions,having a great application potential for repairing bone defect.In this work,a hydroxyapatite(HA)/polydopamine(PDA)composite coating was constructed on the surface of Zn-1Mg porous scaffolds fabricated by laser powder bed fusion,and was loaded with a bioactive factor BMP2 and an antibacterial drug vancomycin.The microstructure,degradation behavior,biocompatibility,antibacterial performance and osteogenic activities were systematically investigated.Compared with as-built Zn-1Mg scaffolds,the rapid increase of Zn2+,which resulted to the deteriorated cell viability and osteogenic differentiation,was inhibited due to the physical barrier of the composite coating.In vitro cellular and bacterial assay indicated that the loaded BMP2 and vancomycin considerably enhanced the cytocompatibility and antibacterial performance.Significantly improved osteogenic and antibacterial functions were also observed according to in vivo implantation in the lateral femoral condyle of rats.The design,influence and mechanism of the composite coating were discussed accordingly.It was concluded that the additively manufactured Zn-1Mg porous scaffolds together with the composite coating could modulate biodegradable performance and contribute to effective promotion of bone recovery and antibacterial function. | Zhenbao Zhang Aobo Liu Jiadong Fan Menglin Wang Jiabao Dai Xiang Jin Huanze Deng Xuan Wang Yijie Liang Haixia Li Yantao Zhao Peng Wen Yanfeng Li | 2023 | Bioactive Materials2023，，9： | 2 |
| 9 | A Self-Powered Fast-Response Ultraviolet Detector of p–n Homojunction Assembled from Two ZnO-Based Nanowires显示文摘Nowadays, fabrication of micro/nano-scale electronic devices with bottom-up approach is paid much research attention. Here, we provide a novel micro/nano-assembling method, which is accurate and efficient, especially suitable for the fabrication of micro/nano-scale electronic devices. Using this method, a self-powered ZnO/Sb-doped ZnO nanowire p–n homojunction ultraviolet detector(UVD) was fabricated, and the detailed photoelectric properties were tested. At a reverse bias of -0.1 V under UV light illumination, the photoresponse sensitivity of the UVD was 26.5 and the rise/decay time of the UVD was as short as 30 ms. The micro/nano-assembling method has wide potential applications in the fabrication of specific micro/nano-scale electronic devices. | Yumei Wang Ying Chen Wanqiu Zhao Longwei Ding Li Wen Haixia Li Fan Jiang Jun Su Luying Li Nishuang Liu Yihua Gao | 2017 | Nano-Micro Letters2017，9，1： | 2 |
| 10 | Ultrasensitive electrochemical immuno sensor fo rcarbohydrate antigen 72-4 based on dual signal amplification strategy of nanoporous gold and polyaniline–Au asymmetric multicomponent nanoparticles显示文摘 | Haixia Fan Zhankui Guo Liang Gao | 2015 | Biosensors and Bioelectronics2015，64，： | 1 |
| 11 | A Review of Causes,Influencing Factors and Countermeasures of Haze Pollution in China显示文摘Haze pollution is a hot research topic at present,and it is of great significance to prevent and control haze pollution.In this paper,specific causes of haze pollution in China are analyzed by literature research and summary,and impacts of economic structure,energy structure and compound factors on haze pollution are explored.Finally,the prevention and control measures of haze pollution are summarized. | Chuai Xiaoming Wang Jiajia Zhou Haixia Fan Chao Han Yanjun Gao Jun | 2019 | Meteorological and Environmental Research2019，10，3： | 1 |
| 12 | Ultrasensitive electrochemical immunoassay for squamous cell carcinoma antigen using dumbbell-like Pt-Fe304 nanoparticles as signal amplification显示文摘 | Wu Dan Fan Haixia Li Yuyang | 2013 | Biosens Bioelectron2013，46，1： | 1 |
| 13 | Electrochemical bisphenolAsensorbasedonN-dopedgraphenesheets显示文摘 | FAN HAIXIA LI YAN WU DAN | 2012 | Analytica Chimica Acta2012，711，1： | 1 |
| 14 | Electrochemical bisphenol A sensor based on N-doped graphene sheets 显示文摘 | Fan Haixia Li Yan Wu Dan | 2012 | Analytica Chimica Acta2012，711，： | 1 |
| 15 | Electrochemical bisphenol A sensor based on N-doped graphene sheets显示文摘 | Haixia Fan Yan Li Dan Wu Hongmin Ma Kexia Mao Dawei Fan Bin Du He Li Qin Wei | 2011 | Analytica Chimica Acta2011，，： | 1 |
| 16 | Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells显示文摘 | Anne Le Andrew N. Lane Max Hamaker Sminu Bose Arvin Gouw Joseph Barbi Takashi Tsukamoto Camilio J. Rojas Barbara S. Slusher Haixia Zhang Lisa J. Zimmerman Daniel C. Liebler Robbert J.C. Slebos Pawel K. Lorkiewicz Richard M. Higashi Teresa W.M. Fan Chi V. | 2012 | Cell Metabolism2012，，1： | 1 |
| 17 | Electrochemical bisphenol Asensor based on N-doped graphene sheets 显示文摘 | FAN Haixia LI Yan WU Dan | 2012 | Analytica Chimica Acta2012，711，2： | 1 |
| 18 | Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells显示文摘 | Anne Le Andrew N. Lane Max Hamaker Sminu Bose Arvin Gouw Joseph Barbi Takashi Tsukamoto Camilio J. Rojas Barbara S. Slusher Haixia Zhang Lisa J. Zimmerman Daniel C. Liebler Robbert J.C. Slebos Pawel K. Lorkiewicz Richard M. Higashi Teresa W.M. Fan Chi V. | 2012 | Cell Metabolism2012，，1： | 1 |
| 19 | Electrochemical bisphenol A sensor based on N -doped graphene sheets 显示文摘 | Haixia Fan Yan Li Dan Wu | 2012 | Analytica Chimica Acta2012，711，： | 1 |
| 20 | The modification of electroless deposited Ni–P master alloy for hypereutectic Al–Si alloy显示文摘 | Jian Guo Ying Liu Pengxu Fan Haixia Qu Tao Quan | 2010 | Journal of Alloys and Compounds2010，，1： | 1 |
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