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174篇 您的检索式：作者名="Hamacher"

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	题名	作者	年代	出处	被引量
1	Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways显示文摘AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma cells.METHODS: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of gelatinases.RESULTS: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P<0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P<0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells predominantly.Furthermore, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein kinase. Specific blockade of the ERK pathway suppresses gelatinase expression either in the presence or absence of TIMP-1.CONCLUSION: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9.	Elke Roeb Anja-Katrin Bosserhoff Sabine Hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern	2005	World Journal of Gastroenterology2005，11，8：	7
2	Efficient stereospecific synthesis of no-carrier-added 2- -fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution 显示文摘	Hamacher K Coenen HH Stocklin G	1986	J Nucl Med1986，27，：	1
3	C of the head by use of reduced current and kilovoltage:relationship between image quality and dose reduction显示文摘	Cohnen M Fischer H Hamacher J	2000	AJNR2000，21，：	1
4	Adapting polyhedral properties from facility to hub location problems显示文摘	HAMACHER H W LABB M NICKEL S	2004	Discrete Applied Mathematics2004，145，1：	1
5	CT of the head by use of reduced current and kilovoltage: relationship between image quality and dose reduction显示文摘	Mathias Cohnen Hubert Fischer Jurgen Hamacher	2000	AJNR2000，21，10：	1
6	A separation a!gorithm for improved LP-decoding of linear block codes 显示文摘	Tanatmis A Ruzika S Hamacher H W	2010	IEEE Transactions on Information Theory2010，56，7：	1
7	Optical filters based on ring resonators with integrated semiconductor optical amplifiers in GaInAsP-InP显示文摘	Rabus D G Hamacher M Troppenz U	2002	IEEE J Sel Topics Quantum Electron2002，6，6：	1
8	EGF-receptor tyrosine kinase inhibition induces keratinoeyte growth al'St and terminal differen- tiation显示文摘	Peus D Hamacher L Pittelkow MR	1997	J Invest Dermatol1997，109，6：	1
9	Optimization under uncertainty of the integrated oil supply chain using stochastic and robust programming显示文摘	RIBAS G P HAMACHER S STREET A	2010	International Transactions in Operational Research2010，17，6：	1
10	Leahcate treatment by the combination of photchemical oxidation wiht biological process显示文摘	In-Ock Koh Xiaoling Chen Hamacher	2004	Journal of Photochemistry and Photobiology A:Chemistry2004，162，：	1
11	Belastungsdiagramme bei Huftgelenks-erkrankungen显示文摘	Hamacher P RSsler H	1974	Z Orthop1974，112，：	1
12	Serum bactericidal activities and comparative pharmaeokineties of meropenem and imipenem-cilastatin显示文摘	Dreetz M Hamacher J Eller J	1996	Antimierob Agents Chemother1996，40，1：	1
13	The stability of 2--fluoro-2-deoxy-D-glucose towards empimerisation under alkaline conditions显示文摘	Meyer G J Matzke K H Hamacher K	1999	Appl Radiat Isot1999，，：	1
14	Multicriteria semi-obnoxious network location problems (MSNLP) with sum and center objectives 显示文摘	Hamacher H W Labbe M Nicke S	2002	Annals of Operations Research2002，110，：	1
15	Efficient stereospecific synthesis of no-carried added 2-1-18 F3 fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution显示文摘	Hamacher K Coenen H H Stocklin G	1986	J NuclMed1986，27，2：	1
16	Structural model of the gas vesicle protein GvpA and analysis of GvpA mutants in vivo显示文摘	Strunk T Hamacher K Hoffgaard F	2011	Mol Microbiol2011，81，1：	1
17	A Lagrangean decomposition approach for oil supply chain investment planning under uncertainty with risk considerations显示文摘	F. Oliveira V. Gupta S. Hamacher I.E. Grossmann	2012	Computers and Chemical Engineering2012，，：	1
18	Effects of lung vilumere duction surgery for emphysema ondlmensions and configuration显示文摘	Hamacher J Verbandt Y	2001	Am J Respir Crit Care Med2001，163，2：	1
19	Sensitivity analysis in fuzzy linear programming显示文摘	Leberling H Zimmerman H	1978	Fuzzy Sets and Systems1978，1，：	1
20	Efficient stereospecific synthesis of no-carrier-added 2--fluoro-2-deoxy-D-glucose using amino-polyether supported nucleophilic substitution 显示文摘	Hamacher K Coenen H H Stocklin G	1986	J Nucl Med1986，27，2：	1

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