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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 3 | The effect of published reports of unethical conduct on stock prices显示文摘 | RAO S M HAMILTON J B | 1996 | Journal of Business Ethics1996，，12： | 1 |
| 4 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 5 | Redox, pH and SP variation over mineralization in thick gla eial overburden显示文摘 | Hamilton S M Cameron E M McClenaghan M B | 2004 | Geochemistry: Exploration Environ ment AnaLysis2004，4，： | 1 |
| 6 | First Paper:Measurementof the Oil-film Thickness between the Piston Ringsand Liner of a Small Diesel Engine显示文摘 | Hamilton G M Moore S L | 1974 | Proceedings ofthe Institution of Mechanical Engineering1974，188，1： | 1 |
| 7 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 8 | Feline ilial fractures:a prospective study of dorsal plating and comparisonwith lateral plating显示文摘 | Langley-Hobbs S J Meeson R L Hamilton M H | 2009 | Vet Surg2009，38，： | 1 |
| 9 | An EWMA for monitoring a process standard deviation显示文摘 | CROWDER S V HAMILTON M D | | 0，，01： | 1 |
| 10 | Time-domain modeling of pulsed finite- amplitude sound beams 显示文摘 | Lee Y S Hamilton M F | 1995 | Journal of the Acoustical Society of America1995，97，2： | 1 |
| 11 | Feline ilial fractures:assessment of screw loosening and pelvic canal narrowingafter lateral plating显示文摘 | Hamilton M H Evans D A Langley-Hobbs S J | 2009 | Vet Surg2009，38，： | 1 |
| 12 | The Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification 显示文摘 | HAMILTON G MIDDLETON M S BYDDER M | 2009 | J Magn Reson Imaging2009，30，1： | 1 |
| 13 | Obstetric and perina- tal outcomes in singleton pregnancies resulting from IVF/IC- SI:asystematic review and meta analysis显示文摘 | Pandey S Shetty A Hamilton M | 2012 | Hum Reprod Update2012，18，5： | 1 |
| 14 | Refractory clostridium difficile-associated diarrhea 显示文摘 | Grover S Hamilton M J Carr-locke DL | 2007 | Med Gen Med2007，9，2： | 1 |
| 15 | Lymphovascular invasion is associated with poor survival in gastric cancer: all application of gene-expression and tissue array techniques显示文摘 | Dieken B J Graham K Hamilton S M | 2006 | Ann Surg2006，243，1： | 1 |
| 16 | A novel rabbit model of variably compensated corn plete heart block显示文摘 | Suto F Cahill S A Wilson G J Hamilton R M Greenwald I Gross G J | 2002 | J Appl Physiol2002，92，： | 1 |
| 17 | TGF-beta inhibits LPS-induced chemokine mRNA stabilization显示文摘 | Dai Y Datta S Novotny M Hamilton T | 2003 | Blood2003，102，4： | 1 |
| 18 | Geochemistry, mineralogy and petrology of a new find of ultramafic lamprophyres from bull- jah Pool, nabberu Basin, Yilgarn Craton, Western Australia 显示文摘 | Hamilton R Rock N M S | 1990 | Lithos1990，24，： | 1 |
| 19 | Thyroid cancer in childhood: a retrospective review of childhood course 显示文摘 | O'GORNIAN C S HAMILTON J RACHMIEL M | 2010 | Thyroid2010，20，4： | 1 |
| 20 | Peripheral Blood Mononuclear Cells Immunophenotyping in Pulmonary Tuberculosis Patients before and after Treatment显示文摘 | Warly Barcelos Olindo Assis Martins‐Filho Tania Mara Pinto Dabés Guimar?es Márcio Hamilton Prostzner Oliveira Silvana Spíndola‐de‐Miranda Beatriz Nascimento Carvalho Vicente de Paulo Coelho Peixoto Toledo | 2006 | Microbiology and Immunology2006，，： | 1 |
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