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| 1 | Recent Trends and Recommendations for Nitrogen Fertilization in Intensive Agriculture in Eastern China显示文摘The Taihu Region in eastern China is one of China's most intensive agricultural regions and also one of the economically most developed areas. High nitrogen balance surpluses in the summer rice-winter wheat double-cropping systems are leading to large-scale non-point source pollution of aquifers. In an interdisciplinary approach, four-year (1995-1998) field trials were carried out in two representative areas (Jurong County and Wuxi City) of the Taihu Region. Five farmers' field sites were chosen in each of the 2 locations, with each site divided into 'standard' (farmers' practice) and 'reduced' (by 30%-40%) N fertilization. For both fertilization intensities, N balance surpluses and monetary returns from grain sales minus fertilizer expenditures were calculated in an economic assessment. Based on the field trials, the mineral N fertilizer application rates reduced by about 10% for rice and 20%-30% for wheat were recommended in 1999. Since 1999, the research focused on the trends in N fertilizer application rates and changes in grain and agricultural commodities prices.Summer rice N fertilizer use, in Wuxi City as of 2001, dropped by roughly 25%, while for winter wheat it decreased by 10%-20%, compared to the 1995-1998 period. This has been achieved not only by grain policy and price changes, but also by an increased environmental awareness from government officials. Nitrogen balance surpluses in Anzhen Town (of Wuxi City) have consequently diminished by 50%-75% in rice and by up to 40% in wheat, with reductions being achieved without concomitant decreases in physical grain yields or returns from sales minus fertilizer costs. | M.ROELCKE HANYong K.H.SCHLEEF ZHUJian-Guo LIUGang CAIZu-Cong J.RICHTER | 2004 | Pedosphere2004，14，4： | 54 |
| 2 | Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing显示文摘The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite(As~Ⅲ), monomethylarsonous acid(MMA~Ⅲ) originating from the oxide and iodide forms, dimethylarsinous acid(DMA~Ⅲ), dimethylarsinic glutathione(DMAG~Ⅲ), phenylarsine oxide(PAO~Ⅲ), arsenate(AsV), monomethylarsonic acid(MMA~Ⅴ), dimethylarsinic acid(DMA~Ⅴ),monomethyltrithioarsonate(MMTTA~Ⅴ), dimethylmonothioarsinate(DMMTA~Ⅴ),dimethyldithioarsinate(DMDTA~Ⅴ), 3-nitro-4-hydroxyphenylarsonic acid(Roxarsone, Rox),and 4-aminobenzenearsenic acid(p-arsanilic acid, p-ASA). Cellular responses were measured in real time for 72 hr in human lung(A549) and bladder(T24) cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry(ICP-MS). On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order: PAO~Ⅲ? MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ? MMTTA~Ⅴ> AsV> DMDTA~Ⅴ>DMA~Ⅴ> MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity. | Birget Moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 19 |
| 3 | Temporal changes in SSR allelic diversity of major rice cultivars in China显示文摘Forty simple sequence repeats (SSRs) were used to assess the changes of diversity in 310 major Chinese rice cultivars grown during the 1950s-1990s. Of the 40 SSR loci, 39 were polymorphic. A total of 221 alleles were detected with an average of 5.7 alleles per locus (Na). The Nei’s genetic diversity index (He) varied drastically among the loci (0.207 to 0.874, mean 0.625). Comparing the temporal changes in Na and He, the cultivars from the 1950s had more alleles and higher He scores than the cultivars from the other four decades Analysis of molecular variance (AMOVA) indicated that the genetic differentiation among the five decades was not significant in the whole set, but significant within indica and japonica. More changes among the decades were revealed in indica cultivars than in japonica cultivars. Some alleles had been lost in current rice cultivars in the 1990s, occurring more frequently in indica. These results suggest that more elite alien genetic resources should be explored to widen the genetic backgrounds of rice cultivars currently grown in China. | Xinghua Wei Xiaoping Yuan Hanyong Yu Yiping Wang Qun Xu Shengxiang Tang | 2009 | Journal of Genetics and Genomics2009，36，6： | 16 |
| 4 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 5 | Genetic characterization and linkage disequilibrium mapping of resistance to gray leaf spot in maize(Zea mays L.)显示文摘Gray leaf spot(GLS),caused by Cercospora zeae-maydis,is an important foliar disease of maize(Zea mays L.)worldwide,resistance to which is controlled by multiple quantitative trait loci(QTL).To gain insights into the genetic architecture underlying the resistance to this disease,an association mapping population consisting of 161 inbred lines was evaluated for resistance to GLS in a plant pathology nursery at Shenyang in 2010 and 2011.Subsequently,a genome-wide association study,using 41,101 single-nucleotide polymorphisms(SNPs),identified 51 SNPs significantly(P<0.001)associated with GLS resistance,which could be converted into 31 QTL.In addition,three candidate genes related to plant defense were identified,including nucleotidebinding-site/leucine-rich repeat,receptor-like kinase genes similar to those involved in basal defense.Two genic SNPs,PZE-103142893 and PZE-109119001,associated with GLS resistance in chromosome bins 3.07 and 9.07,can be used for marker-assisted selection(MAS)of GLS resistance.These results provide an important resource for developing molecular markers closely linked with the target trait,enhancing breeding efficiency. | Liyu Shi Xiangling Lv Jianfeng Weng Hanyong Zhu Changlin Liu Zhuanfang Hao Yu Zhou Degui Zhang Mingshun Li Xiaoke Ci Xinhai Li Shihuang Zhang | 2014 | The Crop Journal2014，2，Z1： | 9 |
| 6 | Largest Toothed Pterosaur Skull from the Early Cretaceous Yixian Formation of Western Liaoning, China, with Comments on the Family Boreopteridae显示文摘A new pterosaur Moganopterus zhuiana gen. et sp. nov. is erected based on a complete skull with lower jaws and anterior cervical vertebrae. It is characterized by much elongated upper and lower jaws with at least 62 total, long, curved teeth with sharp tips, a well developed parietal crest extending posterodorsally, forming an angle of 15 degrees with the ventral margin of the skull, the ratio of length to width of cervical vertebrae greater than 5:1. The skull length is 750 mm, and it is the largest toothed pterosaur found so far in the world. Based on this new pterosaur, the Boreopteridae can be divided into two subgroups: Boreopterinae sub-fam. nov. and Moganopterinae sub-fam. nov., which is also confirmed by the phylogenetic analysis. | LU Junchang PU Hanyong XU Li WU Yanhua WEI Xuefang | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 6 |
| 7 | A New Oviraptorid Dinosaur (Theropoda: Oviraptorosauria) from the Late Cretaceous of Jiangxi Province, Southern China显示文摘A new oviraptorid dinosaur Jiangxisaurus ganzhouensis gen. et sp. nov., is erected based on a partial skeleton from the Upper Cretaceous Nanxiong Formation of Ganzhou City, Jiangxi Province. The new taxon differs from other oviraptorids in the weakly downturned rostrum of the lower jaw, much-elongated mandible with a height-to-length ratio being about 20% and the length ratio of radius to humerus of about 0.70. This species not only adds a new member to oviraptorid dinosaurs, but also provides more information about oviraptorid paleogeographical distribution in southern China. | WEI Xuefang PU Hanyong XU Li LIU Di Lü Junchang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 6 |
| 8 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 9 | Consumption of rice and fish in an electronic waste recycling area contributes significantly to total daily intake of mercury显示文摘Mercury is a global pollutant due to its widespread use,emission,and long-range transport(Blum,2013;Pacyna et al.,2010).It is considered a priority pollutant due to its neurological toxicity,persistence,and bioaccumulation(Pacyna et al.,2010;Sharma et al.,2015).Mercury pollution can occur when products that contain mercury are improperly disposed of and mercury is released into the air,water,and soil(Zhang and Wong,2007).An estimated 22%of the annual world usage of mercury is in electrical equipment such as batteries,thermometers,and discharge lamps,and electronic devices such as monitors | Hanyong Peng Michael S.Reid X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，12： | 5 |
| 10 | Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery显示文摘为指向的同时的肿瘤的 Subcellular 细胞器特定的 nanoparticles,成像,和药交货具有对癌症治疗的庞大的兴趣。此处,我们报导一根选择指向线粒体的探针 1,它被与 cyanostilbene 和长烷基链一半合并 triphenyl 磷化氢综合。探查 1 被发现经由导致聚集的排放(AIE ) 显示荧光。低分子重量的基于 cyanostilbene 的探查有或没有 anticancer 药, 1 与 ca 形成了狭窄的同类的 nanorod。有 ca 的长度或 nanoparticles 的 110 nm。在水的媒介的 20 nm 直径。自我装配的 cyanostilbene nanoparticles (N1 ) 有选择地在癌症房间的线粒体积累了并且射出荧光。N1 也能交付 anticancer 药, doxorubicin (纪录影片) ,到有高效率的线粒体。更重要地, N1 在正常房间上为癌症房间展出了高度选择的 cytotoxicity。到生物系统的这自我装配的 nanoparticle 的大潜在的应用程序源于它在线粒体聚集的能力。这聚集在癌症房间在 mitochondrial 膜潜力在细胞内部的反应的氧种类并且到减少的产生导致了重要增加。而且,在老鼠的肿瘤织物举起实验建议自我装配的 N1 有能力使内在化并且有效地交付 anticancer 药进肿瘤纸巾。而且, N1 和包含 N1 的 doxorubicin (N1 纪录影片) 有效地在 vivo 在一个异种皮移植模型压制了肿瘤生长。一起拿,我们的调查结果显示 N1 的应用程序为潜在的指导图象的治疗以及一个地点特定的交货系统作为指向探查,药交货平台,和化学疗法的代理人的 mitochondrial 提供唯一的策略给癌症房间。 | Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae Jong Hwa Jung | 2018 | Nano Research2018，11，2： | 4 |
| 11 | Lithofacies distribution characteristics and its controlling factors of shale in Wufeng Formation-Member 1 of Longmaxi Formation in the Jiaoshiba area显示文摘It is essential to investigate shale lithofacies distribution and controlling factor of the shale for geological evaluation of shale gas exploration and development.Through comprehensive analysis of cores,thin sections,cathode luminescence,whole-rock X-ray diffraction,element capture spectroscopy,major/trace element and other data,three major types and eight sub-type shale lithofacies in the shale of Wufeng Formation-Member 1 of Longmaxi Formation in Jiaoshiba area are identified by the three-end-member method and shale lithological classification nomenclature,and the spatiotemporal distribution law and main development controlling factors of shale lithofacies are well studied.In the Jiaoshiba area,vertically,the marine shale develops siliceous shale,mixed shale and argillaceous shale from bottom to top.Besides,lateral distribution of the shale is different from north to south;the shale lithofacies in the north area changes rapidly,the mixed shale in the north area is much thicker than that in the south area,while the siliceous shale in the south area is relatively thicker.Difference in the shale lithofacies is controlled by special sedimentary geologic events;development of the siliceous shale is controlled by the Ordovician-Silurian global volcanic event to some extent,while the mixed shale is significantly influenced by effect of bottom current,and the argillaceous shale is mainly affected by supply of terrestrial clastic material. | Chao Wang Baiqiao Zhang Yongchao Lu Zhiguo Shu Yaqiu Lu Hanyong Bao Zhiyong Meng Lei Chen | 2018 | Petroleum Research2018，3，4： | 4 |
| 12 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 13 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 14 | A New Lizard(Lepidosauria:Squamata) from the Upper Cretaceous of Henan,China显示文摘Funiusaurus luanchuanensis gen.et sp.nov.was described on the basis of an incomplete skull from the Upper Cretaceous Qiupa Formation of the Tantou Basin in Luanchuan County,Henan Province.It is the second representative of lizards known from Luanchuan and adds a new member to the Luanchuan Fauna.F.luanchuanensis is a small-sized lizard and systematically assigned to the Polyglyphanodontidae of the Teiioidea because of the presence of a caniniform tooth and an elongate posterior process of the postorbital.It is distinctive in that the heterodont dentition bears 19 teeth in both the upper and lower jaws,the 3rd maxillary tooth is large and caniniform,the post-caniniform teeth in maxilla and those posterior to the 3rd dentary tooth are chisel-like in lateral view,the prefrontal possesses a fossa on its lateral surface,the postorbital with an extremely elongate posterior process and the well-developed retroarticular process has a deep fossa on its dorsal surface.In phylogeny,our analysis suggests a close relationship of Funiusaurus to the large-sized Tianyusaurus from the same basin within the Tuberocephalosaurinae.The discovery of Funiusaurus is significant in confirming the status of the Tuberocephalosaurinae,which includes a group of the Asian members of the Polyglyphanodontidae only. | XU Li WU Xiaochun Lü Junchang JIA Songhai ZHANG Jiming PU Hanyong ZHANG Xingliao | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 2 |
| 15 | Control and Optimization of Sampled-Data Systems with Quantization and Actuator Saturation显示文摘This paper is concerned with control and optimization for a sampled-data system with quantization and actuator saturation. Based quantization and actuator saturation a controller is introduced. The corresponding closed loop system is transformed into a system with input saturation and bounded external disturbance. A new Lyapunov functional is constructed to derive a sample-interval dependent condition on the existence of a state feedback controller such that the closed-loop system is exponentially convergent to an ultimate ellipsoid for the initial condition starting from some initial ellipsoid. Based on the condition, the desired controller is designed. Furthermore, optimization problems about the sample-interval, the ultimate ellipsoid and the initial ellipsoid are formulated. An example is given to illustrate the effectiveness of the proposed method. | SHAO Hanyong ZHAO Jianrong | 2017 | Journal of Systems Science & Complexity2017，30，6： | 2 |
| 16 | Desalination with a cascade of cross-flow hollow fiber membrane distillation devices integrated with a heat exchanger 显示文摘 | Lee Hanyong He Fei Song Liming | 2011 | AIChE Journal2011，57，7： | 1 |
| 17 | Delay-range-dependent robust H∞ filtering for uncertain stochastic systems with mode-dependent time delays and Markovian jump parameters显示文摘 | SHAO Hanyong | | 0，，2： | 1 |
| 18 | Improved delay-dependent stability criteria for systems with a delay varying in a range 显示文摘 | SHAO Hanyong | 2008 | Automatica2008，44，12： | 1 |
| 19 | Optimal and Spatial Analysis of Hormones, Degrading Enzymes and Isozyme Profiles in Tomato Pedicel Explants During Ethylene-Induced Abscission显示文摘 | Yanchang Wang Tianlai Li Hanyong Meng Xiaoyun Sun | 2005 | Plant Growth Regulation2005，，2： | 1 |
| 20 | Quantitative business decision - making for the investment of preventing safety accidents in chemical plants显示文摘 | Hyungjoon Yoon Hanyong Lee II Moon | 2000 | ELSEVIER Computers and Chemical Engineering2000，，24： | 1 |
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