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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing显示文摘Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment.However,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device readings.To address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching.The resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation layers.We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption. | Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 3 | The value-relevance of R&D and advertising显示文摘 | HANA H B D MANRY | 2004 | The International Journal of Accounting2004，，39： | 1 |
| 4 | U- sing near infrared data to classify tobacco types and identify native grown tobacco显示文摘 | Hana M McClure W F Whitaker T B | 1997 | J Near Infrared Spectr1997，，5： | 1 |
| 5 | ~tmln'ate n~hydrate crystals inhibit ostooblast viability and function: implications for development of bone erosion in gout 显示文摘 | ~hana A Callon K E Pool B | 2011 | Ann Rheum Dis2011，70，9： | 1 |
| 6 | Investigation of the ability of the corrosion protection of Zn-Mg coatings 显示文摘 | Hana F Brahim T Mohammed B | 2009 | The Open Corrosion Journal2009，，2： | 1 |
| 7 | Structured discharge education improves early outcome in orthopedic patients显示文摘 | Bela B M Amir H Hana K | 2010 | Int J Orthop Trauma Nurs2010，14，2： | 1 |
| 8 | Soluble methionine enhances accumulation of a 15 kDa zein, a methionine- rich storage protein, in transgenic alfalfa but not in transgenic tobacco plants 显示文摘 | Amira G Ifat M Tal A Hana B Shmuel Rachel A | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 9 | Endurable water - repellent glass for automobiles 显示文摘 | HONG B S HANA J H KIMA S T | 1999 | Thin Solid Films1999，351，： | 1 |
| 10 | Improvement of in vitro micropropagation of Lilium oriental hybrid 'Casablanca' by the formation of shoots with abnormally swollen basal plates显示文摘 | Hana B H Yae B W Yu H J | 2005 | Scientia Horiculturae2005，103，： | 1 |
| 11 | Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes:a controlled crossover study显示文摘 | Hanas B | 2003 | Pediatrics2003，111，51： | 1 |
| 12 | Neural network ap- proximation of iron oxide reduction process 显示文摘 | Tomasz Wiltowski Krzysztof Piotrowski Hana Lorethova Lubor Stonawski Kanchan Mondal Lalvani S B | 2005 | Chemical Engi- neering and Processing2005，44，： | 1 |
| 13 | Epidermal growthfactor reduce the development of necrotizing enterocolitis in aneonatal rat model显示文摘 | Dvorak B Halpern M D Hana H | 2002 | Am J Physiol Liver Physiol2002，282，1： | 1 |
| 14 | Sorption of dyes from aqueous solutions onto fly ash 显示文摘 | Pavel J Hana B Milena R | 2003 | Water Res2003，37，2： | 1 |
| 15 | A guidance directrix approach to vision-based vehicle guidance systems显示文摘 | Hana S Zhang Q Nic B | 2004 | Computers and Electronics in Agriculture2004，43，3： | 1 |
| 16 | Systemic and mucosal immunity induced by attenuated Salmonella enteriea serovar Typhimurium expressing ORF7 of porcine reproductive and respiratory syndrome virus 显示文摘 | Hana Y W Kima S B Rahman M | 2011 | Compar Immunol Microbiol Infect Dis2011，34，4： | 1 |
| 17 | Endurable water - repellent glass for automobiles 显示文摘 | HONG B S HANA J H KIMA S T | 1999 | Thin Solid Films1999，351，： | 1 |
| 18 | Genetic and pathobiologic characterization of Pandemic H1N1 2009 influenzaes from a naturally infected swine herd 显示文摘 | Hana M Weingartl Yohannes B | 2010 | J Virol2010，84，5： | 1 |
| 19 | Cultivation of Anaplasma marginale from cattle in a Dermacentor cell line显示文摘 | SAMISH M PIPANO E HANA B | 1998 | Am J Vet Res1998，49，2： | 1 |
| 20 | Inorganic-organic hybrid porous materials based on graphite oxide sheets 显示文摘 | Zhang D D Zua S Z Hana B H | 2009 | Carbon2009，47，13： | 1 |
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