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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | 选择性雄激素受体调节剂治疗迟发性男性性腺功能低下症显示文摘几种睾酮制剂用于治疗老年男性性腺功能减退。这些疗法在其便利性、灵活性、区域供应和费用等方面有区别,但有共同的药代动力学基础,同时缺乏长期安全性数据。简洁和成本较低的基于药代动力学的注册临床试验使得开发改善性的治疗迟发性性腺功能减退的新疗法的商业动机减少了。在前列腺、头发、皮肤受雄激素缺乏影响的患者中,选择性雄激素受体调节剂已被证明可以提供合成代谢的好处。(目前,选择性雄激素受体调节剂的临床进展集中在有限定身体功能的临床终点的急性肌肉萎缩和低体重)。在具有有益的药理、理想的药代动力学的选择性雄激素受体调节剂应用于治疗迟发性男性性腺功能低下症前,其在男性性腺功能低下治疗中关于临床缺陷的更清晰的监管是必须的。 | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 3 | A novel means of self-protection, unrelated to toxinactivation, cofers immunity to bactericidal effects of the Enterococcus cytolysin显示文摘 | Cobum P S Hancock L E Booth M C | 1999 | Infect Immun1999，67，7： | 1 |
| 4 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
| 5 | Pattern Vectors from Algebraic Graph Theory显示文摘 | Wilson R C Hancock E R Luo B | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，： | 1 |
| 6 | MRI findings are more common in selected patients with acute low back pain than controls显示文摘 | Hancock M Maher C Macaskil P | | 0，，02： | 1 |
| 7 | The unsteady motion of a twodimensional airfoil in incompressible inviscid flow显示文摘 | HANCOCK G J | 1978 | Journal of Fluid Mechanics1978，87，1： | 1 |
| 8 | Micro-scalemeasurement of the mechanical properties of com-pressed pharmaceutical powders (2):The dynamic moduli of microcrystalline cellulose显示文摘 | Dalton C R Clas S-D | 2001 | Int JPharm2001，228，12： | 1 |
| 9 | Enhancement of Freezing Tolerance of Strawberry by Heterologous Expression of CBFI显示文摘 | OWENS C L LEZZONI A F HANCOCK J F | 2003 | ActaHort2003，，626： | 1 |
| 10 | Bayesian graph edit distance显示文摘 | MYERS R WILSON R C HANCOCK E R | 2000 | IEEE Trans on Pattern Analysis and Machine Intelligence2000，22，6： | 1 |
| 11 | Ileal digestibility of crude protein, amino acids, dry matter and phosphorous in pigs fed diets steam conditioned at low and high temperature, expander conditioned or extruder processed 显示文摘 | LUNDBLAD K K HANCOCK J D BEHNKE K C | 2012 | Animal Feed Science and Technology2012，172，34： | 1 |
| 12 | Micro-scale measurement of the mechanical properties of com-pressed pharmaceutical powders (1):The elasticity and fracture behavior of microcrystalline cellulose显示文摘 | Clas S-D Christensen K | 2000 | Int J Pharm2000，209，12： | 1 |
| 13 | Temodar offers promise for treating astrocytomas显示文摘 | Armstrong T Hancock C | 2003 | Clin J Oncol Nurs2003，4，4： | 1 |
| 14 | Screening highbush blueberry cultivars for resistance to phomopsis canker显示文摘 | Baker J B Hancock J F Ramsdell D C | 1995 | HortScience1995，30，3： | 1 |
| 15 | In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide显示文摘 | Lange C F Hancock R E Samuel J | 2001 | J Pharm Sci2001，90，10： | 1 |
| 16 | Minimal residual disease status before allogeneic bone marrow transplantation is an important determinant of successful outcome for children and adolescents with acute lymphoblastic leukemia显示文摘 | Knechth C J Goulden N J Hancock JP | 1998 | Blood1998，92，11： | 1 |
| 17 | Distortional Buckling Formulas for Channel Columns 显示文摘 | Lau S C W Hancock G J | 1987 | Journal of Structural Engineering1987，113，5： | 1 |
| 18 | Protective genes expressed in endo thelial cells:a regulatory response to injury显示文摘 | Bach F H Hancock W W Ferran C | 1997 | Immunol Today1997，18，10： | 1 |
| 19 | Effect of a yeast product in pelleted diets for weanling pigs显示文摘 | MALONEY C A NEMECHEK C S HANCOCK J D | 1998 | Journal of Animal Science1998，76，： | 1 |
| 20 | Effects of particle size and pelleting on growth performance, nutrient digestibility,and stomach morphology in finishing pigs显示文摘 | WONDRA K J HANCOCK J D BEHNKE K C | 1995 | J Anim Sci1995，73，： | 1 |
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