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| 1 | Biliary complications following liver transplantation显示文摘Biliary tract complications are the most common complications after liver transplantation.These complications are encountered more commonly as a result of increased number of liver transplantations and the prolonged survival of transplant patients.Biliary complications remain a major source of morbidity in liver transplant patients,with an incidence of 5%-32%.Post liver transplantation biliary complications include strictures(anastomotic and non-anastomotic),leaks,stones,sphincter of Oddi dysfunction,and recurrence of primary biliary disease such as primary sclerosing cholangitis and primary biliary cirrhosis.The risk of occurrence of a specific biliary complication is related to the type of biliary reconstruction performed at the time of liver transplantation.In this article we seek to review the major biliary complications and their relation to the type of biliary reconstruction performed at the time of liver tranplantation. | Gursimran Kochhar Jose Mari Parungao Ibrahim A Hanouneh Mansour A Parsi | 2013 | World Journal of Gastroenterology2013，19，19： | 41 |
| 2 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 3 | Management of immunosuppressant agents following livertransplantation:Less is more显示文摘Immunosuppression in organ transplantation was revolutionary for its time,but technological and population changes cast new light on its use.First,metabolic syndrome(MS) is increasing as a public health issue,concomitantly increasing as an issue for post-orthotopic liver transplantation patients;yet the medications regularly used for immunosuppression contribute to dysfunctional metabolism.Current mainstay immunosuppression involves the use of calcineurin inhibitors;these are potent,but nonspecifically disrupt intracellular signaling in such a way as to exacerbate the impact of MS on the liver.Second,the impacts of acute cellular rejection and malignancy are reviewed in terms of their severity and possible interactions with immunosuppressive medications.Finally,immunosuppressive agents must be considered in terms of new developments in hepatitis C virus treatment,which undercut what used to be inevitable viral recurrence.Overall,while traditional immunosuppressive agents remain the most used,the specific side-effect profiles of all immunosuppressants must be weighed in light of the individual patient. | Mustafa S Ascha Mona L Ascha Ibrahim A Hanouneh | 2016 | World Journal of Hepatology2016，8，3： | 5 |
| 4 | 营养不良:实验室指标vs营养评估显示文摘营养不良是患者并发症发生率和病死率的一项独立危险因素,并造成医疗费用的增高。然而,由于对营养不良没有一个统一的定义,也没有一个标准的营养不良筛查/诊断方法,导致全世界各地的医生对营养不良在认识上十分混乱,各地的临床实践也有着各不相同的标准。作为营养不良的危险因素,炎症的作用近期已被证实。组织学上,一些血清蛋白如白蛋白和前白蛋白被广泛用于监测患者的营养状态。然而,目前的研究热点是采用恰当的营养状态体格检查(NFPE)来诊断营养不良。目前认为,实验室指标本身不太可靠,只能作为NFPE的一个补充。今后的研究中需要筛选出一些诊断营养不良的血清生物学标志物,这些标志物必须是不受炎症状态影响且具有无创及价格相对低廉的优势。然而,一个完全的NFPE在营养不良的诊断中具有无可替代的作用。 | Shishira Bharadwaj Shaiva Ginoya Parul Tandon Tushar D.Gohel John Guirguis Hiren Vallabh Andrea Jevenn Ibrahim Hanouneh | 2016 | Gastroenterology Report2016，4，4： | 5 |
| 5 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Mustafa S. Ascha Ibrahim A. Hanouneh Rocio Lopez Tarek Abu‐Rajab Tamimi Ariel F. Feldstein Nizar N. Zein | 2010 | Hepatology2010，，6： | 4 |
| 6 | The Role of Rifaximin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis显示文摘 | Mohamad A. Hanouneh Ibrahim A. Hanouneh Jana G. Hashash Ryan Law Jamak Modaresi Esfeh Rocio Lopez Nyla Hazratjee Thomas Smith Nizar N. Zein | 2012 | Journal of Clinical Gastroenterology2012，，8： | 2 |
| 7 | Three-dimensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | Zein NN Hanouneh IA Bishop PD | 2013 | Liver Transpl2013，19，12： | 1 |
| 8 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Ascha MS Hanouneh IA Lopez R | 2010 | Hepatology2010，51，6： | 1 |
| 9 | Diabetes Mellitus Is Associated with Impaired Response to Antiviral Therapy in Chronic Hepatitis C Infection显示文摘 | Hesham M. Elgouhari Claudia O. Zein Ibrahim Hanouneh Ariel E. Feldstein Nizar N. Zein | 2009 | Digestive Diseases and Sciences2009，，12： | 1 |
| 10 | Three-Dimensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | Zein NN Hanouneh IA Bishop PD | 2013 | Liver Transplantation2013，19，12： | 1 |
| 11 | Three-dimensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | Zein NN Hanouneh IA Bishop PD | 2013 | Liver Transpl2013，19，： | 1 |
| 12 | Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children显示文摘 | Naim Alkhouri Frank Cikach Katharine Eng Jonathan Moses Nishaben Patel Chen Yan Ibrahim Hanouneh David Grove Rocio Lopez Raed Dweik | 2014 | European Journal of Gastroenterology & Hepatology2014，，1： | 1 |
| 13 | Three - di- mensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | ZEIN N N HANOUNEH I A BISHOP P D | 2013 | Liver Transpl2013，19，12： | 1 |
| 14 | Recurrent upper gastrointestinal bleeding masquerading as gastric variceal bleeding on endoscopy after liver transplantation显示文摘 | Hanouneh IA Confer BD Zein NN | 2013 | Liver Transpl2013，19，8： | 1 |
| 15 | Three‐dimensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | Nizar N. Zein Ibrahim A. Hanouneh Paul D. Bishop Maggie Samaan Bijan Eghtesad Cristiano Quintini Charles Miller Lisa Yerian Ryan Klatte | 2013 | Liver Transpl2013，，12： | 1 |
| 16 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Ascha MS Hanouneh IA Lopez R | 2010 | Hepatology2010，51，6： | 1 |
| 17 | Recurrent hepatitis C after liver transplantation: on - treatment prediction of response to peginterferon/ribavirin therapy 显示文摘 | Hanouneh I A Miller C Aucejo F | 2008 | Liver Transpl2008，14，1： | 1 |
| 18 | Three-dimensional print of a liver for preoperative planning in living donor liver transplantation显示文摘 | Zein NN Hanouneh IA Bishop PD | 2013 | Liver Transpl2013，19，12： | 1 |
| 19 | Total Tumor Volume Predicts Recurrence of Hepatocellular Carcinoma after Liver Transplantation in Patients Beyond Milan or UCSF Criteria显示文摘 | C. Macaron I.A. Hanouneh R. Lopez F. Aucejo N.N. Zein | 2010 | Transplantation Proceedings2010，，10： | 1 |
| 20 | Risk of colonic neoplasia after liver transplantation for primary sclerosing cholangitis 显示文摘 | Hanouneh IA Macaron C Lopez R | 2012 | Inflamm Bowel Dis2012，18，2： | 1 |
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