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| 1 | 运动神经元病患者血清和脑脊液中NSE和GM1抗体测定及其临床意义显示文摘目的 通过测定运动神经元病 (MND)患者血清和脑脊液 (CSF)中神经元特异性烯醇化酶 (NSE)和 GM1抗体 ,初步探讨其临床意义。方法 应用 ELISA法测定 3 0例 MND患者血清和 CSF中 NSE和 GM1抗体水平。结果 MND组 CSF和血清中 NSE含量均明显高于 NC组 (P<0 .0 1 ,P<0 .0 5) ,而仅在 CSF中 NSE含量高于OND组 (P<0 .0 1 ) ;临床分型以运动神经元损害为主的进行性脊肌萎缩症 (PSMA)患者 CSF中 NSE含量明显高于其他组 (P<0 .0 1 ) ,而血清中 NSE水平在各临床类型间差异并不明显 (P>0 .0 5) ;MND患者血清和 CSF中不论是 Ig M型或是 Ig G型 GM1抗体阳性率均明显高于 OND组和 NC组 (P均 <0 .0 1 ) ;MND患者血清和CSF配对样品 NSE水平有较好的相关性 (r=0 .50 2 ,P<0 .0 1 ) ,MND患者 CSF中 NSE水平与 GM1抗体亦有相关性 (r=0 .4 75,P<0 .0 5) ,其余各组之间均未见明显相关性 (P>0 .0 5)。结论 MND患者 CSF中 NSE和GM1抗体水平可以反映运动系统神经元损害的程度和范围 ;推测这种神经元的损伤可能与 | 乔健 陈向军 吕传真 Hansotto Reiber | 2001 | 中国神经免疫学和神经病学杂志2001，8，2： | 9 |
| 2 | Neuron-Specific Enolase Concentrations in Blood as a Prognostic Parameter in Cerebrovascular Diseases显示文摘 | Henrike Schaarschmidt Hilmar W. Prange Hansotto Reiber | 1994 | Stroke1994，，3： | 2 |
| 3 | Dynamics of brain-derived protein cerebrospinal fluid显示文摘 | Hansotto R | 2001 | Clin Chim Acta2001，310，2： | 1 |
| 4 | Dynamics of brain derived proteins in cerebrospinal fluid显示文摘 | Hansotto R | 2001 | Clin Chim Acta2001，310，2： | 1 |
| 5 | Neuron-specific enolase concentration in blood as a prognostic parameter in cerebrovascular disease显示文摘 | HENRIKE SCHAARSCHMIDT HILMAR W PRANGE HANSOTTO REIBER | 1994 | Stroke1994，25，3： | 1 |
| 6 | Dynamics of brain-derived, protein ecrbrospinal fluid 显示文摘 | Hansotto R | 2001 | Clin Chim Acta2001，310，2： | 1 |
| 7 | Dynamics of brain-derived proteins in cerebrospinal fluid 显示文摘 | Hansotto R | 2001 | Clin Chim Acta2001，310，2： | 1 |
| 8 | Reporting cerebrospinal fluid data:knowledge base and interpretation softerware显示文摘 | Hansotto R Markus O Christian T | 2001 | Clin Chem Lab Med2001，39，： | 1 |
| 9 | Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs显示文摘 | Hansotto Reiber James B. Peter | 2001 | Journal of the Neurological Sciences2001，，： | 1 |
| 10 | Neuron-Specific Enolase Concentrations in Blood as a Prognostic Parameter in Cerebrovascular Diseases显示文摘 | Henrike Schaarschmidt Hilmar W. Prange Hansotto Reiber | 1994 | Stroke1994，，3： | 1 |
| 11 | Proteins in cerebrospinal fluid and blood:Barriers, CSF flow rate and souree-related dynamics显示文摘 | Hansotto Reiber | 2003 | Restorative Neurology and Neurescience2003，21，34： | 1 |
| 12 | The discrimination between different blood-CSF bartier dysfunctions and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of CSF 显示文摘 | Hansotto Reiber | 1980 | J Neurol1980，224，： | 1 |
| 13 | Dynamics of braln-derived proteins in cerebrospinal fluid显示文摘 | Hansotto Reiber | 2001 | Clinica Chimica Acta2001，310，2： | 1 |
| 14 | Proteins in cerebrospinal fluid and blood: Barriers, CSF flow rate and source related dynamics 显示文摘 | Hansotto Reiber | 2003 | Restorative Neurology and Neuroseience2003，21，34： | 1 |
| 15 | Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases显示文摘 | Henrike Schaarschmidt Hilmar W Prange Hansotto Reiber | 1994 | Stroke1994，25，3： | 1 |
| 16 | Proteins in cerebrospinal nuid and blood:Barriers,CSF flow rate and source-related dynamics显示文摘 | Hansotto Reiber | 2003 | Restorative Neurology and Neuroscience2003，21，34： | 1 |
| 17 | Dynamics of brain-derived proteins in cerebrospinal fluid显示文摘 | Hansotto Reiber | 2001 | Clinica Chimica Acta2001，310，2： | 1 |
| 18 | Reporting cerebrospinal fluid data: knowledge base and interpretation soft- erware显示文摘 | Hansotto R Markus O Christian T | 2001 | Clin Chem Lab Med2001，39，3： | 1 |
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