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| 1 | Novel MSX1 variants identified in families with nonsyndromic oligodontia显示文摘The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants.Whole-exome sequencing(WES)and Sanger sequencing were performed to identify the causal gene variants in five families with nonsyndromic oligodontia,and a series of bioinformatics databases were used for variant confirmation and functional prediction.Phenotypic characterization of the members of these families was described,and an in vitro analysis was performed for functional evaluation.Five novel MSX1 heterozygous variants were identified:three missense variants[c.662A>C(p.Q221P),c.670C>T(p.R224C),and c.809C>T(p.S270L)],one nonsense variant[c.364G>T(p.G122*)],and one frameshift variant[c.277delG(p.A93Rfs*67)].Preliminary in vitro studies demonstrated that the subcellular localization of MSX1 was abnormal with the p.Q221P,p.R224C,p.G122*,and p.A93Rfs*67 variants compared to the wild type.Three variants(p.Q221P,p.G122*,and p.A93Rfs*67)were classified as pathogenic or likely pathogenic,while p.S270L and p.R224C were of uncertain significance in the current data.Moreover,we summarized and analysed the MSX1-related tooth agenesis positions and found that the type and variant locus were not related to the severity of tooth loss.Our results expand the variant spectrum of nonsyndromic oligodontia and provide valuable information for genetic counselling. | Jinglei Zheng Miao Yu Haochen Liu Tao Cai Hailan Feng Yang Liu Dong Han | 2021 | International Journal of Oral Science2021，13，1： | 4 |
| 2 | Caspase‐3 Modulates Regenerative Response After Stroke显示文摘 | Wenying Fan Yiqin Dai Haochen Xu Ximin Zhu Ping Cai Lixiang Wang Chungang Sun Changlong Hu Ping Zheng Bing‐Qiao Zhao | 2014 | Stem Cells2014，，2： | 1 |
| 3 | Enhanced photon communication through Bayesian estimation with an SNSPD array显示文摘Laser communication using photons should consider not only the transmission environment’s effects,but also the performance of the single-photon detector used and the photon number distribution.Photon communication based on the superconducting nanowire single-photon detector(SNSPD)is a new technology that addresses the current sensitivity limitations at the level of single photons in deep space communication.The communication’s bit error rate(BER)is limited by dark noise in the space environment and the photon number distribution with a traditional single-pixel SNSPD,which is unable to resolve the photon number distribution.In this work,an enhanced photon communication method was proposed based on the photon number resolving function of four-pixel array SNSPDs.A simulated picture transmission was carried out,and the error rate in this counting mode can be reduced by 2 orders of magnitude when compared with classical optical communication.However,in the communication mode using photon-enhanced counting,the four-pixel response amplitude for counting was found to restrain the communication rate,and this counting mode is extremely dependent on the incident light intensity through experiments,which limits the sensitivity and speed of the SNSPD array’s performance advantage.Therefore,a BER theoretical calculation model for laser communication was presented using the Bayesian estimation algorithm in order to analyze the selection of counting methods for information acquisition under different light intensities and to make better use of the SNSPD array’s high sensitivity and speed and thus to obtain a lower BER.The counting method and theoretical model proposed in this work refer to array SNSPDs in the deep space field. | XIANG LI JINGROU TAN KAIMIN ZHENG LABAO ZHANG LIJIAN ZHANG WEIJI HE PENGWEI HUANG HAOCHEN LI BIAO ZHANG QI CHEN RUI GE SHUYA GUO TAO HUANG XIAOQING JIA QINGYUAN ZHAO XUECOU TU LIN KANG JIAN CHEN PEIHENG WU | 2020 | Photonics Research2020，8，5： | 1 |
| 4 | Reduction of mercury(Ⅱ)by electrons contained in carbon dots:An environmentally friendly cold vapor generation for mercury analysis显示文摘In this work,the reduction of mercury ions(Hg2+)to elemental mercury(Hg0)was easily achieved using highly reductive carbon dots(r-CDs),which synthesized from sucrose by a simple and cost-effective method.After a careful mechanistic study,the reduction was probably accomplished with the large numbers of electrons contained in r-CDs rather than the oxidation of its functional groups.Additionally,a3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay showed that the r-CDs were nontoxic to wildlife and human beings.Consequently,the r-CDs were used as an alternative to toxic reductants(SnCl2 or NaBH4)for the sensitive and in situ determination of mercury by cold vapor gene ration(CVG)coupled to a miniature point discharge optical emission spectrometer(μPD-OES).Limit of detection of 0.05μg/L was obtained for Hg2+,with relative standard deviation(RSD)less than 5.4%at a concentration of 5μg/L.The accuracy of r-CDs induced CVG-μPD-OES was validated by the determination of mercury in a certified reference material(DOLT-5,dogfish liver)and five natural water samples collected from different rivers and lakes in Chengdu City,Since r-CDs are nontoxic and prepared from abundant and inexpensive sucrose,the r-CDs induced CVG-μPD-OES retains the great potential for the inexpensive and enviro nmentally friendly field analysis of mercury in natural water.The accuracy of the proposed method was validated by the analysis of a certified reference material and several water samples with satisfactory results. | Tao Chen Yao Lin Haochen Li Rui Yang Xiandeng Hou Baozhan Zheng Chengbin Zheng | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
| 5 | Improvement of Ga_(2)O_(3)vertical Schottky barrier diode by constructing NiO/Ga_(2)O_(3)heterojunction显示文摘The high critical electric field strength of Ga_(2)O_(3)enables higher operating voltages and reduced switching losses in power electronic devices.Suitable Schottky metals and epitaxial films are essential for further enhancing device performance.In this work,the fabrication of vertical Ga_(2)O_(3)barrier diodes with three different barrier metals was carried out on an n--Ga_(2)O_(3)homogeneous epitaxial film deposited on an n+-β-Ga_(2)O_(3)substrate by metal-organic chemical vapor deposition,excluding the use of edge terminals.The ideal factor,barrier height,specific on-resistance,and breakdown voltage characteristics of all devices were investigated at room temperature.In addition,the vertical Ga_(2)O_(3)barrier diodes achieve a higher breakdown volt-age and exhibit a reverse leakage as low as 4.82×10^(-8)A/cm^(2)by constructing a NiO/Ga_(2)O_(3)heterojunction.Therefore,Ga_(2)O_(3)power detailed investigations into Schottky barrier metal and NiO/Ga_(2)O_(3)heterojunction of Ga_(2)O_(3)homogeneous epitaxial films are of great research potential in high-efficiency,high-power,and high-reliability applications. | Xueqiang Ji Jinjin Wang Song Qi Yijie Liang Shengrun Hu Haochen Zheng Sai Zhang Jianying Yue Xiaohui Qi Shan Li Zeng Liu Lei Shu Weihua Tang Peigang Li | 2024 | Journal of Semiconductors2024，45，4： | 0 |
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