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| 1 | Mechanisms involved in antineuralgic effects of Paeonia Lactiflora: prediction based on network pharmacology显示文摘目的:白芍的镇痛作用已被广泛应用于中医临床,但对其潜在机制知之甚少.本研究旨在从网络药理学的角度阐明其有效成分和镇痛机制.方法:通过中药系统药理学分析平台(TCMSP)筛选出其可能的活性成分及CAS.从Pubchem 中获得其SMILES,并通过在Swiss Target Prediction 数据库中反向对接获得潜在的靶点.从GeenCards 数据库中提取疼痛相关分子,采用韦恩图筛选出芍药治疗疼痛的预测靶点.机制分析采用String 构建蛋白-蛋白相互作用,运用DAVID 平台进行靶点GO 功能富集和KEGG 信号通路富集.结果:通过GO 和KEGG 分析我们发现疼痛相关的信号通路主要涉及血清素能突触、钙信号通路、调控TRP 通道的炎症介质.利用基于网络的系统生物学和分子对接分析,我们预测了白芍中的11 种活性成分和97 个潜在的治疗靶标.PRKCA、CASP3、ALOX15、SLC6A4、PRKCG、ALOX5、PRKCB、ALOX12、 EGFR、ADRB2、RYR3、RYR1、NOS2、PTAFR、PRKCQ、PRKCD 等基因参与了白芍的镇痛作用.结论:白芍可通过调节TRP 通道炎症介质、钙信号通路和5-羟色胺受体减轻疼痛.PRKCA、PRKCB、PRKCD、 PRKCQ 和PRKCG 可能是疼痛治疗的新靶标. | Di Zhang Shengsuo Ma Jianxin Sun Bing Yang Haoming Lin Meijing Xie Meina Huang Guoping Zhao | 2019 | TMR Clinical Research2019，2，2： | 8 |
| 2 | Experimental study of wind turbine blade power augmentation using airfoil flaps,including the gumey flap显示文摘 | Bao Nengsheng Ma Haoming | 2000 | Wind Engineering2000，24，1： | 1 |
| 3 | A systemic review of hydrogen supply chain in energy transition显示文摘Targeting the net-zero emission(NZE)by 2050,the hydrogen industry is drastically developing in recent years.However,the technologies of hydrogen upstream production,midstream transportation and storage,and downstream utilization are facing obstacles.In this paper,the development of hydrogen industry from the production,transportation and storage,and sustainable economic development perspectives were reviewed.The current challenges and future outlooks were summarized consequently.In the upstream,blue hydrogen is dominating the current hydrogen supply,and an implementation of carbon capture and sequestration(CCS)can raise its cost by 30%.To achieve an economic feasibility,green hydrogen needs to reduce its cost by 75%to approximately 2$/kg at the large scale.The research progress in the midterm sector is still in a preliminary stage,where experimental and theoretical investigations need to be conducted in addressing the impact of embrittlement,contamination,and flammability so that they could provide a solid support for material selection and largescale feasibility studies.In the downstream utilization,blue hydrogen will be used in producing value-added chemicals in the short-term.Over the long-term,green hydrogen will dominate the market owing to its high energy intensity and zero carbon intensity which provides a promising option for energy storage.Technologies in the hydrogen industry require a comprehensive understanding of their economic and environmental benefits over the whole life cycle in supporting operators and policymakers. | Haoming MA Zhe SUN Zhenqian XUE Chi ZHANG Zhangxing CHEN | 2023 | Frontiers in Energy2023，17，1： | 1 |
| 4 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 5 | Study of the Structure of the Shenzhen Fault Zone with the Magnetotelluric Method显示文摘The magnetotelluric sounding method was used to study the active fault in Shenzhen city.Four magnetotelluric profiles with a dense station interval were laid out across the Shenzhen fault zone.The remote reference technique was used in both data observation and processing to eliminate the electromagnetic noise near the survey sites,and relatively smooth apparent resistivity curves were obtained.TM mode data and two-dimensional inversion method as NLCG were used to obtain the electrical structures underground.According to the surficial geology survey results on regional strata and distribution of magmatic bodies and faults,the electrical structures at depths less than 2000m of each profile were interpreted.Two regional faults,the Henggang-Luohu fault and the Liantang fault,and seven local faults consistent with the electrical boundaries were verified or discovered.The strata in the survey area were then related with the change of resistivity.Electrical horizontal slices of depths less than 5000m indicate that the Henggang-Luohu fault and the Liantang fault bifurcate at the shallow part but tend to merge in the deep part. | Chen Panglong Xiao Qibin Zhao Guoze Ma Haoming | 2011 | Earthquake Research in China2011，25，2： | 0 |
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