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| 1 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 2 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 3 | Effect of Ischemia–Reperfusion on Bile Canalicular F-Actin Microfilaments in Hepatocytes of Human Liver Allograft显示文摘 | Liliane Benko?l Frank Dodero Jean Hardwigsen Pierre Campan Danielle Botta-Fridlund Dominique Lombardo Yves Patrice Le Treut Albert Chamlian | 2001 | Digestive Diseases and Sciences2001，，8： | 2 |
| 4 | A life - threatening complication of focal nodular hyperplasia显示文摘 | Hardwigsen J Pons J Veit V | 2001 | J Hepatol2001，34，2： | 1 |
| 5 | Resection of the inferior vena cava for neoplasms with or without prothetic replacement : a 14-patient series显示文摘 | Hardwigsen J Baque P Crespy B | 2001 | Am Surg2001，223，2： | 1 |
| 6 | Anatomic variants of the biliary tree with MR cholangiography: feasibility and surgical applications 显示文摘 | Vidal V Hardwigsen J Jacquier A | 2007 | J Chir (Paris)2007，144，： | 1 |
| 7 | Morbidity of major hepatic resections: a 100-case prospective study显示文摘 | Campan P Hardwigsen J | 1999 | Eur J Surg1999，165，： | 1 |
| 8 | Is hepatic resec- tion the best treatment for hydatid cyst? 显示文摘 | Birnbaum D J Hardwigsen J Barbier L | 2012 | J Gastrointest Surg2012，16，11： | 1 |
| 9 | Effect of ischemia-reperfusion on bile canalicular F-actin microfilaments in hepatocytes of human liver allograft-image analysis by confocal laser scanning microscopy 显示文摘 | BENKOEL L DODERO F HARDWIGSEN J | 2001 | Dig Dis Sci2001，46，8： | 1 |
| 10 | Tumeurs kystiques rétropéritonéales compliquées révélatrices d’une lymphangioléiomyomatose显示文摘 | L. Barbier M. Ebbo L. Andrac-Meyer N. Schneilitz Y.-P. Le Treut M. Reynaud-Gaubert J. Hardwigsen | 2009 | Journal de Chirurgie2009，，： | 1 |
| 11 | A life-threatening complication of focal nodular hyperplasia显示文摘 | Hardwigsen J Pons J Veit V | 2001 | J Hepatol2001，35，2： | 1 |
| 12 | Resection of the inferior vena cava for neoplasms with or without prothetic replacement:a 14-patient series显示文摘 | Hardwigsen J Baque P Crespy B | 2001 | Ann Surg2001，223，2： | 1 |
| 13 | Resection of Hepatocellular Carcinoma with Tumor Thrombus in the Major Vasculature. A European Case-Control Series显示文摘 | Y. Patrice Le Treut Jean Hardwigsen Pascal Ananian Jean Sa?sse Emilie Grégoire Hubert Richa Pierre Campan | 2006 | Journal of Gastrointestinal Surgery2006，，6： | 1 |
| 14 | Effect of ischemiareperfusion on bile canalicular F-actin microfilaments in hepatocytes of human liver allograft显示文摘 | Benkoel L Dodero F Hardwigsen J | 2001 | Dig Dis Sci2001，46，8： | 1 |
| 15 | Leiomyosar- coma of the retrohepatic portion of the inferior vena cava:clinical presentation and surgical management in five pa- tients显示文摘 | Hardwigsen J Balandraud P Ananian P | 2005 | J Am Coil Surg2005，200，1： | 1 |
| 16 | Effect of ischemia- reperfusion on bile canalicular F-actin microfilaments in hepato-cytes of human liver allograft: image analysis by confocal laser scanning microscopy显示文摘 | Benkoel L Dodero F Hardwigsen J | 2001 | Dig Dis Sci2001，46，8： | 1 |
| 17 | A life-threatening complication of focal nodular hyperplasia显示文摘 | Hardwigsen J Pons J Veit V | 2001 | J Hepatol2001，35，2： | 1 |
| 18 | Retroperitoneal ectopic pregnancy:report of a case显示文摘 | Terrier J P Garcia S Hardwigsen J | 1998 | Ann Pathol1998，18，3： | 1 |
| 19 | Effect of Ischemia—Reperfusion on Na+,K+-ATPase Expression in Human Liver Tissue Allograft: Image Analysis by Confocal Laser Scanning Microscopy显示文摘 | Liliane Benkoel Frank Dodero Jean Hardwigsen Eric Mas Anne-Marie Benoliel Danielle Botta-Fridlund Yves Patrice Le Treut Albert Chamlian Dominique Lombardo | 2004 | Digestive Diseases and Sciences2004，，9： | 1 |
| 20 | Pancreatic neuroendocrine tumor: A multivariate analysis of factors influencing survival显示文摘 | D.J. Birnbaum O. Turrini J. Ewald L. Barbier A. Autret J. Hardwigsen C. Brunet V. Moutardier Y.-P. Le Treut J.-R. Delpero | 2014 | European Journal of Surgical Oncology2014，，11： | 1 |
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