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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma显示文摘 | Ijichi Hideaki Chytil Anna Gorska Agnieszka E Aakre Mary E Bierie Brian Tada Motohisa Mohri Dai Miyabayashi Koji Asaoka Yoshinari Maeda Shin Ikenoue Tsuneo Tateishi Keisuke Wright Christopher V E Koike Kazuhiko Omata Masao Moses Harold L | 2011 | Journal of Clinical Investigation2011，，10： | 3 |
| 3 | Characterization of sugarcane response to Bipolaris sacchari : Inoculations and host - specific HS - toxin显示文摘 | Brain L B Harold S G Susan S | 1994 | Phytopathol1994，，： | 1 |
| 4 | Remit scheduling during composting based on moisture control显示文摘 | Keener David L | 1996 | Transactions of the ASAE1996，，： | 1 |
| 5 | Mechanismsand factors influencing the ultrasonic cleaningof particle-fouled ceramic membrances显示文摘 | Mikko O L Harold W W Weavers L K | 2004 | Journal ofMembrane Science2004，237，12： | 1 |
| 6 | Terahertz emission from localized modes in one-dimensional disordered systems [Invited]显示文摘We demonstrate terahertz(THz) frequency laser emission around 3.2 THz from localized modes in one-dimensional disordered grating systems. The disordered structures are patterned on top of the double-metal waveguide of a THz quantum cascade laser. Multiple emission peaks are observed within a frequency range corresponding to the bandgap of a periodic counterpart with no disorder, indicating the presence of mode localization aided by Bragg scattering. Simulations and experimental measurements provide strong evidence for the spatial localization of the THz laser modes. | YONGQUAN ZENG GUOZHEN LIANG Bo QIANG Bo MENG Hou KUN LIANG SHAMPY MANSHA JIANPING LI ZHAOHUI L LIANHE LI ALEXANDER GILES DAVIES EDMUND HAROLD LINFIELD YING ZHANG YIDONG CHONG AND Qi JIE WANG | 2018 | Photonics Research2018，6，2： | 1 |
| 7 | Acoustic,aerodynamic,and perceptual analyses of the voice of cochlear-implanted children显示文摘 | HAROLD A GUERRERO L MICHEL M | 2013 | J Voice2013，27，： | 1 |
| 8 | TGF-β stimulation and inhibition of cell proliferation:new mechanistic insights 显示文摘 | Harold L Moses Edmund Y Yang Jennifer A Pletepol | 1990 | Cell1990，63，： | 1 |
| 9 | Dscl Vitamin D, calcium andprevention ofbreast cancer: a review 显示文摘 | Martin L Harold L New mark | 1999 | Am Colle JNutr1999，5，18： | 1 |
| 10 | Effects of formulation on the runoff of imidacloprid from turf显示文摘 | Kevin L Armbrust Harold B Peeler | 2002 | Pest Manag Sci2002，58，7： | 1 |
| 11 | Genetic evidence for the involve-ment of lipid metabolism in Alzheimer's disease显示文摘 | Jones L Harold D Williams J | 2010 | Biochim Bio-phys Acta2010，1801，8： | 1 |
| 12 | INHIBITION OF CARCINOGENESIS BY DIETARY POLYPHENOLIC COMPOUNDS显示文摘 | Chung S Yang Janelle M Landau Mou-Tuan Huang Harold L Newmark | 2001 | Annual Review of Nutrition2001，，： | 1 |
| 13 | V ertica 1 Integ ra tionin Am er icanM anufacturing, 1899-1948显示文摘 | Harold C L ivesay Patrick G Porter | 1969 | The Journalof Econom icH isto ry1969，29，3： | 1 |
| 14 | Mapping from ASRER stereo image data: DEM validation and accuracy assessment显示文摘 | Akira H Roy W Harold L | 2003 | Journal of Photogrammetry & Remote Sensing2003，57，： | 1 |
| 15 | Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events显示文摘 | Harold L Lazar MD Smart R | 2004 | Circulation2004，109，12： | 1 |
| 16 | STRAPand smad7 synergize in the inhibition of transforming growth factorβsignaling显示文摘 | Pran K Harold L Moses | 2000 | Mol Cell Bio2000，，20： | 1 |
| 17 | Variable Antigens of Ureaplasma Urealyticum Containing Both Serovar-Specific and Serovar-Cross-Reactive Epitopes显示文摘 | Harold L W Donna K B Gail H C | 1990 | Infect Immun1990，58，11： | 1 |
| 18 | Computer-assisted audit tools and techniques : analysis and perspectives 显示文摘 | Robert L Harold E | 2003 | Managerial Auditing Journal2003，18，9： | 1 |
| 19 | TGF-B and cancer显示文摘 | Bierie B Harold L Moses H | 2006 | Cytokine : Growth Factor Reviews2006，17，： | 1 |
| 20 | Pletepol TGF-β stimulation and inhibition of cell proliferation: New Mechanistic Insights显示文摘 | Harold L M Edmund Y Y Jennifer A | 1990 | Cell1990，63，： | 1 |
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