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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Evaluating distributed generation impacts with a multiobjective index显示文摘 | Ochoa L F Padilha-Feltrin A Harrison G | 2006 | IEEE Trans on Power Del2006，21，3： | 1 |
| 3 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang W X Yang R Lai Y C Kovanis V Harrison M A F | 2011 | EPL2011，94，48： | 1 |
| 4 | Clouds and the Earth's Radiant Energy System (CERES): An earth observing system experiment 显示文摘 | Wielicki B A Barkstrom B R Harrison E F | 1996 | Bulletin of American Meteorological Society1996，77，： | 1 |
| 5 | Ordered mesoporous Fe2O3 with crystalline walls显示文摘 | Jiao F Harrison A Jumas J C | 2006 | Journal of the American Chemical Society2006，128，16： | 1 |
| 6 | Effects of climate change on nitrogen dynamics in upland soils ( 1 ) : A transplant approach 显示文摘 | Ineson P Taylor K Harrison A F | 1998 | Global Change Biology1998，4，2： | 1 |
| 7 | Optical and Radio Observations of the Afterglow from GRB 990510: Evidence for a Jet显示文摘 | Harrison F A Bloom J S Frail D A | 1999 | APJ1999，523，： | 1 |
| 8 | Development of a novel 3D simulation modelling system for distributed manufacturing显示文摘 | Qin S F Harrison R West A A | 2004 | Computers in Industry2004，54，1： | 1 |
| 9 | The role of the CD44/Ezrin complex in cancer metastasis显示文摘 | MARTIN T A HARRISON G MARTSEL R F | 2003 | Crit Rev Oncol Hematol2003，46，： | 1 |
| 10 | Effects of some ante - mortem stressors on peri - mortem and post - mortem biochemical changes and tenderness in broiler breast muscle 显示文摘 | ALIA S A HARRISON A P JENSEN J F | 1999 | Worlds Poult Sci J1999，55，4： | 1 |
| 11 | Effects of copper on early life history stages of northern anchovy EnCraulis mordax显示文摘 | RICE D W HARRISON F L JEARLD A J | 1980 | Fishery Bulletin1980，78，3： | 1 |
| 12 | Effects of copper of early life history stages of northern anchvy EnCraul is mordax显示文摘 | Rice D W Harrison F L Jearld A J | 1980 | Fishery Bulletin1980，78，3： | 1 |
| 13 | J Anal At Spectrom显示文摘 | KING F L MCCORMACK A L HARRISON W W | 1988 | 3:883-8861988，3，： | 1 |
| 14 | Development of a Novel 3D Simulation Modelling System for Distributed Manufacturing 显示文摘 | Qin S F Harrison R West A A | 2004 | Computers in Industry2004，54，： | 1 |
| 15 | Matrix filter design for passive sonar interference suppression显示文摘 | Vaccaro R J Chhetri A Harrison B F | | 0，，06： | 1 |
| 16 | Clouds and the Earth's Radiant Energy System (CERES):An Earth Observing System Experiment显示文摘 | Barkstrom B R Harrison E F | 1996 | Bul Amer Meteor Soc1996，77，： | 1 |
| 17 | Hybrid model-based approach to batch-to-batch control of particle size distribution in emulsion polymerization显示文摘 | Doyle F J Harrison C A Crowley T J | 2003 | Computers and Chemical Engineering2003，27，： | 1 |
| 18 | Tertiary structural evolution of the Gangdese thrust system in southern Tibet显示文摘 | Yin A Harrison T M Reyerson F J | 1994 | Journal of Geophysical Research1994，99，18： | 1 |
| 19 | Raising Tibet 显示文摘 | Harrison T M Copeland P Kidd W S F Yin A | 1992 | Science1992，255，5052： | 1 |
| 20 | Evaluating distributed generation impacts with a multiobjective index显示文摘 | Ochoa L F Padilha-Feltrin A Harrison G P | | IEEE Trans on Power Delivery0，21，3： | 1 |
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