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| 1 | 不同氮源对海洋微藻氮同位素分馏作用的影响显示文摘以海链藻 (Thalassiosirapseudonana)为研究对象 ,分别考察了以硝酸盐、铵盐和尿素为氮源的氮同位素分馏作用。在建立相应理论模型基础上 ,分别计算出各个实验体系的ε值。结果表明 ,在藻类生长初期 ,δ1 5N均较低 ,其δ1 5N的积累主要发生在指数增长期 ,在稳定期达到最高 ,与氮源的初始δ1 5N相同 ;不同氮源的氮同位素分馏作用也不相同 ,其中以铵盐最强 ,硝酸盐次之 ,尿素最弱。考虑到实际情况下氮化合物并非单一存在 ,作者还进一步考察了上述3种氮源混合后对其同位素分馏作用的影响 ,发现混合氮源体系的表观ε值介于单一氮源时的最大与最小ε值之间 ,该结果较好地解释了Montoya等 ( 1 991 )在Chesapeak湾的现场实验结果。 | 俞志明 Waser N A D Harrison P J | 2004 | 海洋与湖沼2004，35，6： | 13 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Immunoplatelet counting: a proposed new reference procedure显示文摘 | Harrison P Horton A Grant D | 2000 | Brit J Heamat2000，108，： | 2 |
| 4 | Planar chips technology for miniaturization and integration of separation techniques into monitoring systems:capillary electrophoresis on a chip 显示文摘 | MANZ A HARRISON D J VERPOORTE E M J | 1992 | Chromatography1992，593，： | 2 |
| 5 | Impact of 'adverse selection' on managers project evaluation decisions 显示文摘 | HARRISON P D HARREL A | 1993 | Academy of Management Journal1993，36，3： | 1 |
| 6 | A general theory of acute and chronic heart {ailure显示文摘 | Maciver D H Dayer M J Harrison A J | 2013 | Int J Cardiol2013，165，1： | 1 |
| 7 | On the diversity of diversi- ty:Tidy logic,messier realities显示文摘 | Klein K J Harrison D A | 2007 | Academy of Mana- gement Perspectives2007，21，4： | 1 |
| 8 | The JAK/STAT Signaling Pathway显示文摘 | Rawlings J S Rosler K M Harrison D A | 2004 | J Cell Sci2004，17，： | 1 |
| 9 | Thymocyte apoptosis induced by p53-dependent and independent pathways显示文摘 | Purdie C A Harrison D J | 1993 | Nature1993，362，6423： | 1 |
| 10 | Impact of non- corrosive forage stabilizer on chemical composition and storage characteristics of lucerne hay显示文摘 | Deetz D A Harrison J H Evans D W | 1993 | Grass and Forage Science1993，48，： | 1 |
| 11 | Risk and predictors forpregnancy-related complications in women with heart disease 显示文摘 | Siu S C Sermer M Harrison D A | 1997 | Circulation1997，96，9： | 1 |
| 12 | Current and emerging therapies in nonalcoholic fatty liver disease显示文摘 | KASHI M R TORRES D M HARRISON S A | 2008 | Semin Liver Dis2008，28，： | 1 |
| 13 | Nicotinamide prevents the development of diabetes in the cyelophosphamide-induced NOD monse model by reducing bcta-cell apoptosis显示文摘 | OBRIEN B A HARRISON D J YAN W | 2000 | J Pathol2000，191，： | 1 |
| 14 | Hall sensor array for rapid large-area transient eddy current inspection显示文摘 | Smith R A Harrison D J | 2004 | Insight2004，46，3： | 1 |
| 15 | Evolution of a- nartifleial seawater medium: improvement sinenriehed seawa- ter, artifieial water over the last two deeades 显示文摘 | Berges J A Franklin D J Harrison P J | 2001 | Phyeol2001，37，6： | 1 |
| 16 | Symbolic or substantive document? The influence of ethics codes on financial executives' decisions显示文摘 | Stevens J M Steensma H K Harrison D A Cochran P L | | 0，，2： | 1 |
| 17 | Optical and Radio Observations of the Afterglow from GRB 990510: Evidence for a Jet显示文摘 | Harrison F A Bloom J S Frail D A | 1999 | APJ1999，523，： | 1 |
| 18 | Association between Polymorphism in Gene for Microsomal Epoxide Hydrolase and Susceptibility to Emphysema显示文摘 | Harrison D J | 1997 | The Lancet1997，350，： | 1 |
| 19 | Association between polymorphism in gene for micresomal epoxide hydrolase and susceptibility to emphysema 显示文摘 | Smith C A D Harrison D J | 1997 | Lancet1997，350，： | 1 |
| 20 | Syn- ergies and post- acquisition performance: differences versus similarities 显示文摘 | Harrison J S Hoskisson M A H R E Ireland R D | 1991 | Journal of Management1991，17，1： | 1 |
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