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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Cognitive deficits in normally intelligent patients with Tuberous sclerosis显示文摘 | OCallaghan FJ Hancock E | 1999 | Am J Med Genet1999，88，： | 1 |
| 3 | Study of iron stores in regular plateletpheresis donors显示文摘 | Page EA Coppock JE Harrison JF | 2010 | Trsnsfusion Med2010，20，1： | 1 |
| 4 | Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats显示文摘 | Print CG Leung E Harrison JE | 1994 | Gene1994，144，2： | 1 |
| 5 | Protein distribution of the orexin - 2 receptor in the rat central nervous system显示文摘 | Cluderay JE Harrison DC Hervieu GJ | 2002 | Regul Pept2002，104，13： | 1 |
| 6 | The Impact of Post- discharge Telephonic Follow- Up on Hospital Readmissions 显示文摘 | Harrison PL Hara PA Pope JE | 2011 | Population Health Management2011，14，1： | 1 |
| 7 | Successful homotransplantation of the human kidney between identical twins 显示文摘 | MERRILL JP MURRAY JE HARRISON JH | 1984 | JAMA1984，251，19： | 1 |
| 8 | The relative effect of azone and transcutol on permeantdiffusivity and solubility in human stratum comeum显示文摘 | Harrison JE Watkinson AC Green DM | 1996 | Pharm Res1996，13，4： | 1 |
| 9 | Atypical plague bacilli isolated from rodents, fleas, and man 显示文摘 | Williams JE Harrison DN Quan T J | 1978 | Am J Public Health1978，68，： | 1 |
| 10 | Treatment of convulsive status epilepticus with propofol:a case report显示文摘 | Harrison AM Lugo RA Schunk JE | 1997 | Pediatr Emerg Care1997，13，3： | 1 |
| 11 | Procyanidin contributions to haze formation in an aerobically produced apple juice haze 显示文摘 | Beveridge T Harrison JE Weintraub SE | 1997 | Lebensmittel Wissenschaft and Technologic1997，30，： | 1 |
| 12 | Clinical Resistance to Enfuvirtide Does Not Affect Susceptibility of Human Immunodefieiency Virus Type i to Other Classes of Entry Inhibitors 显示文摘 | Ray N Harrison JE Blackburn L | 2007 | J Virol2007，81，： | 1 |
| 13 | Ca2+ and Na+ in rat myocytes showing different force-frequency relationships 显示文摘 | Harrison SM Boyett MR | 1991 | Am J Physiol1991，261，51： | 1 |
| 14 | Successful pregnancies after human renal transplantation显示文摘 | Marray JE Harrison JH Merrill JP | 1963 | N Engl J Med1963，269，： | 1 |
| 15 | How to… Find the Evidence显示文摘 | Harrison JE | 2003 | J Orthod2003，30，1： | 1 |
| 16 | Renal homotransplantation in identical twins显示文摘 | Harrison JH Merrill JP Murray JE | 1956 | Surg Forum1956，6，： | 1 |
| 17 | Neuroprotection of the brain during cardiopulmonary bypass:a randomised trial of remacemide during coronary artery bypass in171 patients显示文摘 | Arrowsmith JE Harrison MJ Newman SP | 1998 | Stroke1998，29，11： | 1 |
| 18 | The relative effect of Azone trandeutol on permeant diffusivity and solubility in human stratum comeum显示文摘 | Harrison JE Watkinson AC Green DM | 1996 | Pharm Res1996，13，： | 1 |
| 19 | Successful pregnancies after human renal transplantation 显示文摘 | Murray JE Reid DE Harrison JH | 1963 | N Engl J Med1963，269，： | 1 |
| 20 | Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis显示文摘 | Joseph JE Harrison P Mackie IJ | 2001 | Br J Haematol2001，115，： | 1 |
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