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| 1 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 2 | Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice显示文摘 | Hatoum HT Lin S J Buchner D | 2012 | Support Care Cancer2012，20，5： | 1 |
| 3 | Usefulness of red cell distribution width in predicting all-cause long-term mortality after non-ST-elevation myocardial infarction显示文摘 | Azab B Torbey E Hatoum H | 2011 | Cardiology2011，119，2： | 1 |
| 4 | Solitary splenic metastasis of ovarian carcinoma:a case report显示文摘 | Karui D Kopelman D Abu Hatoum O | 2014 | Med Case Rep2014，8，1： | 1 |
| 5 | Obrago: Patient Counseling--enhancing patient outcomes显示文摘 | Hatoum HT Hutchinson RA Lambert BL | 1993 | US Pharm1993，18，7： | 1 |
| 6 | Hypoxia-inducible factor in cancer angiogenesis: structure, regulation and clinical perspectives 显示文摘 | Otrock ZK Hatoum HA Ahmad AH | 2009 | Crit Rev Oncol Hematol2009，70，2： | 1 |
| 7 | Continuous fluid resuscitation and splenectomy for teatment If uncontrolled hemorrhagic shock afer massive splenic injury 显示文摘 | Ossama Abu Hatoum Yulia BSc Mark Hirsh | 2002 | J Trauma2002，52，： | 1 |
| 8 | Usefulness of red cell distribution width in predicting all-cause long-term mortality after non-ST- elevation myocardial infarction显示文摘 | Azab B Torbey E Hatoum H | 2011 | Cardiology2011，119，2： | 1 |
| 9 | The vasculature and inflammatory bowel disease: contribution to pathogenesis and clinical pathology显示文摘 | Hatoum OA Binion I)(3 | 2005 | In- flamm Bowel Dis2005，11，3： | 1 |
| 10 | Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes显示文摘 | Hatoum I J Hu F B Nelson J J | | 0，，05： | 1 |
| 11 | Lipopro- tein-associated phospholipase A2 activity improves risk discrimination of incident coronary heart disease among women显示文摘 | Hatoum I J Cook NR Nelson J J | 2011 | Am Heart J2011，161，3： | 1 |
| 12 | Zoledronie acid and skeletal complications in patients with solid tumors and bone metastases: analysis of a National Medical claims database显示文摘 | Hatoum liT Lin SJ Smith MR | 2008 | Cancer2008，113，6： | 1 |
| 13 | Continuous fluid resus- citation and splenectomy for treatment of uncontrolled hemorrhagic shock after massive splenic injury显示文摘 | Abu Hatoum O Bashenko Y Hirsh M | 2002 | J Trauma2002，52，2： | 1 |
| 14 | Usefulness of red cell distribution width in predicting albcause long-term mortality after non-ST elevation myocardial infarction显示文摘 | Azab B Torbey E Hatoum H | 2011 | Cardiology2011，119，2： | 1 |
| 15 | Continuous fluid resusci- tation and spleneetomy for treatment of uncontrolled hemorrhagic shock after massive spienie injury 显示文摘 | Ahu Hatoum O Bashenko Y Hirsh M | 2002 | J Trauma2002，52，2： | 1 |
| 16 | Metastasis of colorectalcarcinoma to the testes:clinical presentation and possible pathways显示文摘 | Hatoum HA Abi Saad GS Otrock ZK | 2011 | Int J Clin Oncol2011，16，3： | 1 |
| 17 | Paradox of simuhaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease 显示文摘 | HATOUM O A BINION D G GU33'ERMAN D D | 2005 | Eur J Clin Invest2005，35，10： | 1 |
| 18 | Mesentericvenous thrombosis in inflammatory bowel disease显示文摘 | Hatoum OA Spinelli KS Abu-Hajir M | 2005 | J ClinGastroenterol2005，39，1： | 1 |
| 19 | Emerging role of epoxyeicosatrienoic acids in coronary vascular function 显示文摘 | Larsen BT Gutterman DD Hatoum OA | 2006 | Eur J Clin Invest2006，36，5： | 1 |
| 20 | Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis显示文摘 | Kabbout M Hatoum A Abou-Lteif G | 2004 | Mol Carcinog2004，40，1： | 1 |
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