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| 1 | Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy显示文摘BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano | 2019 | World Journal of Gastroenterology2019，25，4： | 6 |
| 2 | Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device显示文摘AIM To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) for small rectal submucosal tumors(SMTs).METHODS Between August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device(ESMR-L)(n = 21) or ESD(n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes.RESULTS The rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resectionwas higher in the ESD group than in the ESMR-L group(100% vs 95.2%), there were no significant differences between the two groups(P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group(14.7 ± 6.4 min vs 5.4 ± 1.7 min, P < 0.05). The mean period of the hospitalization was also significantly longer in the ESD group than in the ESMR-L group(3.7 ± 0.9 d vs 2.8 ± 1.5 d, P < 0.05). Postoperative bleeding was occurred in one patient in the ESMR-L group.CONCLUSION Both ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 3 | Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis显示文摘瞄准:显示出是否分子的马达达因在在一条微导管轨道,分子的马达肌浆球蛋白 Va,马达 recruiter 肌浆球蛋白 Va, VIIa-Rab27a/b 交往蛋白质(MyRIP ) ,和泡受体上,一条 F 肌动朊轨道上的 Rab27b 在包含 intramanchette 运输(IMT ) 的人和猴子精子形式期间是在场的。方法:Spermiogenic 房间与妨碍的精子缺乏和正常成年 cynomolgus 猴子(Macacafascieularis ) 从三个人被获得。Immunocytochemical 察觉和反向的抄写聚合酶链反应(RT-PCR ) 蛋白质的分析被执行。样品被轻显微镜分析。结果:用 RT-PCR,我们发现了那达因在,肌浆球蛋白 Va, MyRIP 和 Rab27b 在猴子睾丸被表示。,这些蛋白质对领局部性由免疫荧光出现,特别地在人和猴子精子形式期间。结论:我们推测在首领精子形式期间,填写基于微导管、基于肌动朊的泡的那些蛋白质搬运系统,这实际上是在领的现在并且可能可能涉及 intramanchette 运输。 | Shinichi Hayasaka Yukihiro Terada Kichiya Suzuki Haruo Murakawa Ikuo Tachibana Tadashi Sankai Takashi Murakami Nobuo Yaegashi Kunihiro Okamura | 2008 | Asian Journal of Andrology2008，10，4： | 3 |
| 4 | An electronic nose using a single graphene FET and machine learning for water, methanol, and ethanol显示文摘The poor gas selectivity problem has been a long-standing issue for miniaturized chemical-resistor gas sensors.The electronic nose(e-nose)was proposed in the 1980s to tackle the selectivity issue,but it required top-down chemical functionalization processes to deposit multiple functional materials.Here,we report a novel gas-sensing scheme using a single graphene field-effect transistor(GFET)and machine learning to realize gas selectivity under particular conditions by combining the unique properties of the GFET and e-nose concept.Instead of using multiple functional materials,the gas-sensing conductivity profiles of a GFET are recorded and decoupled into four distinctive physical properties and projected onto a feature space as 4D output vectors and classified to differentiated target gases by using machine-learning analyses.Our single-GFET approach coupled with trained pattern recognition algorithms was able to classify water,methanol,and ethanol vapors with high accuracy quantitatively when they were tested individually.Furthermore,the gas-sensing patterns of methanol were qualitatively distinguished from those of water vapor in a binary mixture condition,suggesting that the proposed scheme is capable of differentiating a gas from the realistic scenario of an ambient environment with background humidity.As such,this work offers a new class of gas-sensing schemes using a single GFET without multiple functional materials toward miniaturized e-noses. | Takeshi Hayasaka Albert Lin Vernalyn C.Copa Lorenzo P.Lopez Jr Regine A.Loberternos Laureen Ida M.Ballesteros Yoshihiro Kubota Yumeng Liu Arnel A.Salvador Liwei Lin | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 5 | An Asian emission inventory of anthropogenic emission sources for the period 1980–2020显示文摘 | Ohara T. Akimoto H. Kurokawa J. Horii N. Yamaji K. Yan X. Hayasaka T | 2007 | Atmospheric Chemistry and Physics2007，，100： | 2 |
| 6 | Analyses of fatal cases of Kawasaki disease in Japan using vital statistical data over 27 years显示文摘 | Hayasaka S Nakamura Y Yashiro M | 2003 | J Epidemiol2003，13，5： | 1 |
| 7 | Small cell neuroendocrine carcinomas of the uterine cervix: a histological, immunohistoehemical, and molecular genetic study显示文摘 | Ishida G M Kato N Hayasaka T | 2004 | Int J Gynecol Pathol2004，23，： | 1 |
| 8 | The role of sili- con in preventing appressorial penetration by the rice blast fungus 显示文摘 | HAYASAKA T FUJII H ISHIGURO K | 2008 | Phytopathology2008，98，9： | 1 |
| 9 | Elevated plasma levels of matrix metalloproteinase-9 (92kD type collagenase/gelatinase B) in hepatocellular carcinoma显示文摘 | HAYASAKA A SUZUKI N FUJIMOTO N | 1996 | Hepatol1996，24，5： | 1 |
| 10 | Manual expression and electric breast pumping in the first 48 h after delivery 显示文摘 | Ohyama M Watabe H Hayasaka Y | 2010 | Pediatrics International2010，52，1： | 1 |
| 11 | Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings显示文摘 | Kazumasa Hayasaka Kazuo Morita Tomoya Saitoh Yoshiaki Tanaka | 2006 | Computerized Medical Imaging and Graphics2006，，： | 1 |
| 12 | Epoxidation of ethylene over silver catalysts supported on α-alumina crystal carriers显示文摘 | Akimi Ayame Yoshio Uchida Hiroyuki Ono Masaaki Miyamoto Tomoyuki Sato Hirofumi Hayasaka | 2002 | Applied Catalysis A, General2002，，1： | 1 |
| 13 | Effects of baicalin,baicalein,and wogonin on interteukin-6 and interleukin-8 expression,and nuclear factor-kappa B binding activities induced by interleukin-1 beta in human retinal pigment epithelial cell line显示文摘 | Hayasaka S Zhang XY | 2003 | Exp Eye Res2003，77，2： | 1 |
| 14 | Design,manufacture,stress analysis,and experimental tests of low-noise high endurance spiral bevel gears显示文摘 | Litvin F L Fuentes A Hayasaka K | 2006 | Mechanism and Machine Theory2006，41，1： | 1 |
| 15 | Design,manufacture,stress analysis,and experimental tests of low-noise high endurance spiral bevel gears显示文摘 | Litivin Faydor L Alfonso Fuentes Kenichi Hayasaka | 2006 | Mechanism and Machine Theory2006，41，： | 1 |
| 16 | Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments显示文摘 | Sugahara K N Hirata T Hayasaka H | 2006 | J Biol Chem2006，281，9： | 1 |
| 17 | Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections显示文摘 | SHRIVAS K HAYASAKA T GOTO-INOUE N | 2010 | Analytical Chemistry2010，82，21： | 1 |
| 18 | Saturation mapping with subclones of YACs: DNA marker production targeting the rice blast disease resistance gene, Pi-b显示文摘 | L. Monna A. Miyao H. S. Zhong M. Yano M. Iwamoto Y. Umehara N. Kurata H. Hayasaka T. Sasaki | 1997 | TAG Theoretical and Applied Genetics1997，，2： | 1 |
| 19 | Psychosocial characteristics of individuals with non-stage IV melanoma显示文摘 | Trask P C Paterson A G Hayasaka S | 2001 | J Clin Oncol2001，19，： | 1 |
| 20 | Data quality assessment and the long-term trend of ground solar radiation in China 显示文摘 | Shi G Y Hayasaka T Ohmura A | 2008 | Journal of Applied Meteorology and Climatology2008，47，： | 1 |
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