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| 1 | Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants显示文摘AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF survival and overall survival. Among patients received CRT, overall survival was significantly longer in patients with negative than positive surgical margin(27.7 mo vs 22.4 mo, P = 0.016) in the overallstudy population, while time of radiotherapy initiation had no significant impact on survival times. Nodal stage was determined to be independent predictor of LRF survival in the overall study population with 4.959 fold(P = 0.042) increase in mortality in patients with nodal stage N2 compared to patients with nodal stage N0, and independent predictor of overall survival with 5.132 fold(P = 0.006), 5.263 fold(P = 0.027) and 4.056 fold(P = 0.009) increase in the mortality in patients with nodal stage N3a(before 2008), N3b(before 2008) and N2(overall study population) when compared to patients with N0 stage, respectively.CONCLUSION: Our findings emphasize the likelihood of postoperative adjuvant CRT to have a survival benefit in patients with resectable gastric carcinoma. | Sevgi Ozden Zerrin Ozgen Hazan Ozyurt Cengiz Gemici Gokhan Yaprak Huseyin Tepetam Alpaslan Mayadagli | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | Influence of electrolyte pH on TiO 2 nanotube formation by Ti anodization显示文摘 | Srimala Sreekantan Zainovia Lockman Roshasnorlyza Hazan Minoo Tasbihi Lee Keat Tong Abdul Rahman Mohamed | 2009 | Journal of Alloys and Compounds2009，，1： | 2 |
| 4 | Photoactivity of anatase–rutile TiO 2 nanotubes formed by anodization method显示文摘 | Srimala Sreekantan Roshasnorlyza Hazan Zainovia Lockman | 2009 | Thin Solid Films2009，，1： | 2 |
| 5 | The epidermal growth factor receptor modu- lates the interaction of E-cadherin with the actin cytoskeleton 显示文摘 | Hazan RB Norton L | 1998 | J Biol Chem1998，273，15： | 1 |
| 6 | Basement membrance alterations in psoriasis are accompanied by epidermal overexpression of MMP-2 and its inhibitor TIMP-2 显示文摘 | Fleisehmajer R Kuroda K Hazan R | 2000 | Invest Dermatol2000，115，5： | 1 |
| 7 | Effective prevention of microbial biofilm formation on medical devices by low-energy surface acoustic waves显示文摘 | Hazan Z Zumeris J Jacob H | 2006 | Antimicrob Agents Chemother2006，50，12： | 1 |
| 8 | Cadherin switch in tumor progression显示文摘 | Hazan RB Qiao R Keren R | 2004 | Ann N Y Acad Sci2004，1014，： | 1 |
| 9 | Romantic love conceptualized as an attachment process显示文摘 | Hazan C Shaver P | 1987 | J Pers Soc Psychol1987，52，3： | 1 |
| 10 | Shaver P显示文摘 | Hazan C | | 0，，03： | 1 |
| 11 | Environmental etch performance and scratch and mar of automotive clear coats 显示文摘 | B V Gregorovich I Hazan | 1994 | Progress in Organic Coatings1994，24，： | 1 |
| 12 | Basement membrane alterations in psoriasis are accompanied by epidermal overexpression of MMP-2 and its inhibitor TIMP-2 显示文摘 | Fleisehmajer R Kuroda K Hazan R | 2000 | J Invest Dermatol2000，115，： | 1 |
| 13 | Exogenous expression of N-cadherin in breast cancer cells induces cell migration,invasion,and metastasis显示文摘 | Hazan RB Phillips GR Qiao RF | 2000 | J Cell Biol2000，148，4： | 1 |
| 14 | Attachment in marriage:Effects of security and accuracy of working model显示文摘 | Kobak R.R Hazan C | | 0，，： | 1 |
| 15 | Repair of bone allograft fracture using bone morphogenetic protein2显示文摘 | LEE FY STORER S HAZAN EJ | 2002 | Cl in Orthop2002，397，： | 1 |
| 16 | Aberrant endometrial features of pregnancy in diabetic NOD mice显示文摘 | Burke SD Dong H Hazan AD | 2007 | Diabetes2007，56，： | 1 |
| 17 | Attachment as an organizational framework for research on close relationships显示文摘 | Hazan C and Shaver P R | 1994 | Psychological Inquiry1994，5，1： | 1 |
| 18 | High solids loading ceramic colloidal disper-sions in UV curable media via comb-polyelectrolytesurfactants显示文摘 | YORAM De Hazan JUDIT Heinecke ALFRED We-ber | 2009 | Journal of Colloid and Interface Sci-ence2009，337，1： | 1 |
| 19 | Aggressive peri- odontitis diagnosed during or before orthodontic treatment 显示文摘 | Hazan - Molina H Levin L Einy S | 2013 | Aeta Odontol Scand2013，71，5： | 1 |
| 20 | Why Democracies Collapse: the Reasons for Democratic Failure and Success 显示文摘 | Diskin A Diskin H Hazan R | 2005 | International Political Science Review2005，，26： | 1 |
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