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| 1 | 年龄>80岁患者的收缩压轨迹、衰弱和全因死亡率:电子健康记录队列研究显示文摘血压随年龄而升高,老年人高血压患病率较高。收缩压升高可能是老年人心血管病的最重要危险因素。最近几项大型临床试验显示,降压药降低血压的同时可降低老年人的心血管事件和死亡率。对年龄〉80岁患者进行降压治疗的老老年高血压试验(hypertension in the very elderly trial, | Ravindrarajah R Hazra NC Hamada S Charlton J Jackson SHD Dregan A Gulliford MC 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，7： | 22 |
| 2 | Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells显示文摘基础切除修理(BER ) 是为由消除损坏的几打维持 genomic 完整的 evolutionarily 保存的进程(氧化或烷基 ated ) 或内长地被产生或由 genotoxicants 导致了的不恰当的库,主要反应的氧种类(ROS ) 。BER 包含由脱氧核糖核酸 glycosylase 以基础切除开始的 4-5 步骤,由通常包含 AP-endonuclease (无尾猿) 产生 3' 的一条普通小径列在后面哦在损坏地点的终点,与由脱氧核糖核酸连接酶封上的 DNA 和刻痕由修复合成列在后面。这条小径也负责修理脱氧核糖核酸单个海滨与 ROS 直接产生的堵住的终点决裂。将近所有 glycosylases,比他们特别地为氧化的底的底层损害少得多,宽广、重叠的底层变化,并且能用作备份酶体内。相反,哺乳动物的房间编码仅仅一无尾猿, APE1,不同于在更低的有机体的二无尾猿。尽管有全面类似,有在哺乳动物的不同潜水艇小径的 BER 比在 E 更复杂。关口 i。glycosylases 与下游的蛋白质形成建筑群经由不同潜水艇小径执行有效修理哪个之一,负责因为海滨的修理与 NEIL 家庭 glycosylases 或由 ROS 产生的 3' 磷酸盐终点决裂,要求多核苷酸 kinase 的磷酸酶活动而不是 APE1。不同建筑群可以利用不同 DNA 和 ligases。哺乳动物的 glycosylases 非在终点之一保存了延期、为酶的活动非必需却为和另外的 BER 并且非的相互作用需要 -- 为指向的复杂形成和细胞器的 BER 蛋白质。哺乳动物的酶 covalently 有时被修改它可以影响活动和复杂形成。这评论的焦点在在为氧化损坏的哺乳动物的 BER 的早步上。 | Muralidhar L Hegde Tapas K Hazra Sankar Mitra | 2008 | Cell Research2008，18，1： | 15 |
| 3 | Characterization of Organic-Rich Shales for Petroleum Exploration & Exploitation: A Review-Part 2: Geochemistry, Thermal Maturity, Isotopes and Biomarkers显示文摘As shale exploitation is still in its infancy outside North America much research effort is being channelled into various aspects of geochemical characterization of shales to identify the most prospective basins, formations and map their petroleum generation capabilities across local, regional and basin-wide scales. The measurement of total organic carbon, distinguishing and categorizing the kerogen types in terms oil-prone versus gas-prone, and using vitrinite reflectance and Rock-Eval data to estimate thermal maturity are standard practice in the industry and applied to samples from most wellbores drilled. It is the trends of stable isotopes ratios, particularly those of carbon, the wetness ratio(C1/∑(C2+C3)), and certain chemical biomarkers that have proved to be most informative about the status of shales as a petroleum system. These data make it possible to identify production 'sweet-spots', discriminate oil-, gas-liquid-and gas-prone shales from kerogen compositions and thermal maturities. Rollovers and reversals of ethane and propane carbon isotope ratios are particularly indicative of high thermal maturity exposure of an organic-rich shale. Comparisons of hopane, strerane and terpane biomarkers with vitrinite reflectance(Ro) measurements of thermal maturity highlight discrepancies suggesting that Ro is not always a reliable indicator of thermal maturity. Major and trace element inorganic geochemistry data and ratios provides useful information regarding provenance, paleoenvironments, and stratigraphic-layer discrimination. This review considers the data measurement, analysis and interpretation of techniques associated with kerogen typing, thermal maturity, stable and non-stable isotopic ratios for rocks and gases derived from them, production sweet-spot identification, geochemical biomarkers and inorganic chemical indicators. It also highlights uncertainties and discrepancies observed in their practical application, and the numerous outstanding questions associated with them. | David A.Wood Bodhisatwa Hazra | 2017 | Journal of Earth Science2017，28，5： | 10 |
| 4 | Petrological Characteristics and Genesis of the Central Indian Ocean Basin Basalts显示文摘The Central Indian Ocean Basin (CIOB) basalts are plagioclase-rich, while olivine and pyroxene are very few. The analyses of 41 samples reveal high FeOT (~10-18 wt%) and TiO 2 (~1.4-2.7 wt%) indicating a ferrobasaltic composition. The basalts have high incompatible elements (Zr 63-228 ppm; Nb ~1-5 ppm; Ba ~15-78 ppm; La ~3-16 ppm), a similar U/Pb (0.02-0.4) ratio as the normal mid -oceanic basalt (0.16±0.07) but the Ba/Nb (12.5-53) ratio is much larger than that of the normal midoceanic ridge basalt (~5.7) and Primitive Mantle (9.56). Interestingly almost all of the basalts have a significant negative Eu anomaly (Eu/Eu*=0.78-1.00) that may have been a result of the removal of feldspar and pyroxene during crystal fractionation. These compositional variations suggest that the basalts were derived through fractional crystallization together with low partial melting of a shallow seated magma. | Pranab DAS Sridhar D.IYER Sugata HAZRA | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 6 |
| 5 | Comparison of design of intraocular lens versus the material for PCO prevention显示文摘AIM: To evaluate the influence of different intraocular lens(IOL) designs made of PMMA on posterior capsular opacification(PCO) and compare with foldable designs.· METHODS: Phacoemulsification and IOL implantation was done in one eye of 24 New Zealand White rabbits, with IOL of two different designs (Square edged or round edge) and two different materials(PMMA or HEMA). After three months, the animals were sacrificed and enucleated. Evaluation of PCO included posterior view, migration of anterior capsular epithelial cells to the posterior capsule following epithelial-mesenchymal transition were assessed by staining the histological sections of posterior capsule by hematoxylin-eosin(HE) and Periodic acid- Schiff (PAS). The IOLs were extracted and stained with HE to evaluate the presence of adherent cells on the lens surface. · RESULTS: PCO was highest with round edged rigid lens. There was no significant difference in the PCO between the square edged PMMA and square edged foldable lens.· CONCLUSION: It is the design of the IOL not the material that offers protection on PCO formation. | Sarbani Hazra Himangshu Palui Geeta K Vemuganti | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 5 |
| 6 | Characterization of Organic-Rich Shales for Petroleum Exploration & Exploitation: A Review-Part 1: Bulk Properties, Multi-Scale Geometry and Gas Adsorption显示文摘Shales, the most abundant of sedimentary rocks, are valued as the source-rocks and seals to porous petroleum reservoirs. Over the past-twenty years, organic-rich shales have also emerged as valuable petroleum systems(reservoir, seal, and source rocks contained in the same formation). As such they have become primary targets for petroleum exploration and exploitation. This Part 1 of a three-part review addresses the bulk properties, multi-scale geometry and gas adsorption characteristics of these diverse and complex rocks. Shales display extremely low permeability, and their porosity is also low, but multi-scale. Characterizing the geometry and interconnectivity of the pore-structure frameworks with the natural-fracture networks within shales is essential for establishing their petroleum exploitation potential. Organic-rich shales typically contain two distinct types of porosity: matrix porosity and fracture porosity. In addition to inter-granular porosity, the matrix porosity includes two types of mineral-hosted porosity: inorganic-mineral-hosted porosity(IP); and, organic-matter-hosted(within the kerogen) porosity(OP). Whereas, the fracture porosity and permeability is crucial for petroleum production from shales, it is within the OP where, typically, much of the in-situ oil and gas resources resides, and from where it needs to be mobilized. OP increases significantly as shales become more thermally mature(i.e., within the gas generation zones), and plays a key role in the ultimate recovery from shale-gas systems. Shales' m ethane sorption capacities(MSC) tends to be positively correlated with their total organic carbon content(TOC), thermal maturation, and micropore volume. Clay minerals also significantly influence key physical properties of shale related to fluid flow(permeability) and response to stress(fracability) that determine their prospectivity for petroleum exploitation. Clay minerals can also adsorb gas, some much better than others. The surface area of the pore structure of shales can be positively or negatively correlated with TOC content, depending upon mineralogy and thermal maturity, and can influence its gas adsorption capacity. Part 2 of this three-part review considers, in a separate article, the geochemistry and thermal maturity characteristics of shale; whereas Part 3, addresses the geomechanical attributes of shales, including their complex wettability, a dsorption, water imbibition and 'fracability' characteristics. The objectives of this Part 1 of the review is to identify important distinguishing characteristics related to the bulk properties of the most-prospective, petroleum-rich shales. | David A.Wood Bodhisatwa Hazra | 2017 | Journal of Earth Science2017，28，5： | 4 |
| 7 | Characterization of Organic-Rich Shales for Petroleum Exploration & Exploitation: A Review-Part 3: Applied Geomechanics, Petrophysics and Reservoir Modeling显示文摘Modeling geomechanical properties of shales to make sense of their complex properties is at the forefront of petroleum exploration and exploitation application and has received much research attention in recent years. A shale's key geomechanical properties help to identify its 'fracibility' its fluid flow patterns and rates, and its in-place petroleum resources and potential commercial reserves. The models and the information they provide, in turn, enable engineers to design drilling patterns, fracture-stimulation programs and materials selection that will avoid formation damage and optimize recovery of petroleum. A wide-range of tools, technologies, experiments and mathematical techniques are deployed to achieve this. Characterizing the interconnected fracture, permeability and porosity network is an essential step in understanding a shales highly-anisotropic features on multiple scales(nano to macro). Well-log data, and its petrophysical interpretation to calibrate many geomechanical metrics to those measured in rock samples by laboratory techniques plays a key role in providing affordable tools that can be deployed cost-effectively in multiple well bores. Likewise, microseismic data helps to match fracture density and propagation observed on a reservoir scale with predictions from simulations and laboratory tests conducted on idealised/simplified discrete fracture network models. Shales complex wettability, adsorption and water imbibition characteristics have a significant influence on potential formation damage during stimulation and the short-term and longterm flow of petroleum achievable. Many gas flow mechanisms and models are proposed taking into account the multiple flow mechanisms involved(e.g., desorption, diffusion, slippage and viscous flow operating at multiple porosity levels from nano-to macro-scales). Fitting historical production data and well decline curves to mo del predictions helps to verify whether model's geomechanical assum ptions are realistic or not. This review discusses the techniques applied and the models developed that are relevant to applied geomechanics, highlighting examples of their application and the numerous outstanding questions associated with them. | David A.Wood Bodhisatwa Hazra | 2017 | Journal of Earth Science2017，28，5： | 4 |
| 8 | First fossil evidence of Palaeocarya(Engelhardioideae:Juglandaceae)from India and its biogeographical implications显示文摘Even though presently indigenous to eastern Himalaya in India,no Engelhardioideae have been reported from the Cenozoic sediments of India till date.Here,we report the first Indian occurrence of a characteristic engelhardioid winged samaroid fruit having a tri-lobed wing(oblong-ovate median lobe and two lateral lobes)and a globose nut from the latest Neogene(Pliocene:Rajdanda Formation)sediments of Chotanagpur Plateau,eastern India.This is the first fossil evidence of relict family Juglandaceae from the Indian Cenozoic.We determine its taxonomic position on the basis of detailed macromorphological comparison with similar extant and fossil specimens and discuss its palaeoclimatic significance in terms of the present-day distribution of modern analogous species.We assign this Pliocene winged fruit specimen to the morphogenus Palaeocarya sect.Monocosta Manchester and describe it as a new species,namely Palaeocarya indica Hazra,Hazra M&Khan sp.nov.Palaeocarya sect.Monocosta has rich fossil records from the Cenozoic sediments of Europe,North America,and eastern Asia(China,Korea),but the modern analog,Engelhardia,is presently native only to India and neighboring Southeast Asia.We discuss the possible causes of disappearance of Engelhardia from the present-day vegetation of Chotanagpur Plateau.Its disappearance may be related to the gradual intensification of monsoonal rainfall seasonality since the Pliocene.Here,we also review in detail the biogeographic history of Palaeocarya sect.Monocosta and suggest its possible migration routes. | Taposhi Hazra Manoshi Hazra Sanchita Kumar Sumana Mahato Meghma Bera Subir Bera Mahasin Ali Khan | 2021 | Journal of Systematics and Evolution2021，59，6： | 3 |
| 9 | Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants显示文摘 | George K. Siberry Paige L. Williams Hermann Mendez George R. Seage Denise L. Jacobson Rohan Hazra Kenneth C. Rich Raymond Griner Katherine Tassiopoulos Deborah Kacanek Lynne M. Mofenson Tracie Miller Linda A. DiMeglio D. Heather Watts | 2012 | AIDS2012，，9： | 2 |
| 10 | Meta-analysis of new genome-wide association studies of colorectal cancer risk显示文摘 | Ulrike Peters Carolyn M. Hutter Li Hsu Fredrick R. Schumacher David V. Conti Christopher S. Carlson Christopher K. Edlund Robert W. Haile Steven Gallinger Brent W. Zanke Mathieu Lemire Jagadish Rangrej Raakhee Vijayaraghavan Andrew T. Chan Aditi Hazra Dav | 2012 | Human Genetics2012，，2： | 2 |
| 11 | Imidacloprid in processed tea and tea liquor显示文摘Imidacloprid 是最新介绍的用途广泛的 chloronicotinyl 杀虫药剂并且将在农业生产发现它的方法,特别地在亚洲。然而,在庄稼植物的 imidacloprid 的命运的信息正在缺乏。在处理 CTCtea 和茶白酒的 imidacloprid 的降级在 imidacloprid 以推荐申请率(30.0 g a.i./ha ) 并且两次在被使用的现在的学习被调查为三个连续季节的推荐申请率(60.0 ga.i./ha ) 。Imidacloprid 很快在申请评估的根本首先跟随顺序反应动力学的处理的茶被驱散并且有在茶白酒的残余发现了在第三件天样品上的可检测的限制下面的 0.91-1.16 dwith 的一半生活。学习表明 imidacloprid 为人的消费是安全的并且不提出任何剩余毒性问题。 | SANYAL N. HAZRA D. PAL R. SOMCHAUDHURY A.K. CHOWDHURY A. | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，8： | 2 |
| 12 | 用于白内障超声乳化训练的活体白内障动物模型(英文)显示文摘目的:制备用于白内障超声乳化训练的活体白内障动物模型。方法:狗在全身麻醉下用26号带有斜面的针刺破左眼的晶状体前囊,制备白内障模型,形成白内障后,行超声乳化手术。结果:眼部检查显示晶状体后部皮质混浊开始于穿刺术后5~7d,并于术后75d白内障全部形成,在所有的白内障形成的眼上行超声乳化手术,并植入人工晶状体,所有的狗均恢复了视力。结论:考虑到无经验的眼科医生在行白内障超声乳化手术的初始阶段引起的巨大损失,我们认为这个活的动物模型明显优于目前用于训练超声乳化手术的尸体眼。 | Sarbani Hazra Dipak K De Arup K Bose Biswarup Roy | 2008 | 国际眼科杂志2008，8，6： | 2 |
| 13 | Multiple DNA glycosylas es for repair of 8-oxoguanine and their potential in vivo functions 显示文摘 | Hazra T K Hill J W Izumi T | 2001 | Prog Nucleic Acid Res Mol Biol2001，68，： | 1 |
| 14 | Genotypic control of peanut somatic embryogenesis显示文摘 | Chengalrayan K Mhaske V B Hazra S | 1998 | Plant Cell Report1998，17，： | 1 |
| 15 | Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice显示文摘 | Hazra B Sarkar R Bhanacharyya S | 2002 | Fitoterapia2002，73，8： | 1 |
| 16 | Application of a bio-engineering'technique to protect Ghoramara Island ( Bay of Bengal) from severe erosion显示文摘 | GHOSH T BHANDARI G HAZRA S | 2003 | Journal of Coastal Conservation2003，9，： | 1 |
| 17 | Growth of titanium dioxide thin films via a metallurgical route and characterizations for chemical gas sensors显示文摘 | Hazra S K Roy S Basu S | 2004 | Materials Science and Engineering B2004，110，2： | 1 |
| 18 | Formal verification of architectural power intent显示文摘 | HAZRA A GOYAL S DASGUPTA P | 2013 | Very Large Scale Integration (VLSI) Systems IEEE Transactions on2013，21，1： | 1 |
| 19 | Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer显示文摘 | Amanda I. Phipps Polly A. Newcomb Xabier Garcia–Albeniz Carolyn M. Hutter Emily White Charles S. Fuchs Aditi Hazra Shuji Ogino Hongmei Nan Jing Ma Peter T. Campbell Jane C. Figueiredo Ulrike Peters Andrew T. Chan | 2012 | Gastroenterology2012，，1： | 1 |
| 20 | Gradation of openness显示文摘 | Chattopadhyay K C Hazra R N Samanta S K | 1992 | Fuzzy topology:FSS1992，，49： | 1 |
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