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48篇 您的检索式：作者名="Heeren M"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Triose phosphate isomerase deficiency is caused by altered dimerization not catalytic inactivity-of the mutant enzymes 显示文摘	Ralser M Heeren G Breitenbach M	2006	PLoS ONE2006，1，：	1
3	Direct temperature resolved HRMS of fire-retarded polymers by in-Source PyMS on an external ion source fourier transform ion cyclotron resonance mass spectrometer显示文摘	Heeren R M A De Koster C G Boon J J	1995	Analytical Chemistry1995，67，21：	1
4	Evaluation of Refolding Conditions for a Human Recombinant Fusion Cytokine Protein,Promegapoietin1a显示文摘	BOYLE D M JOHNSON G V HEEREN R A	2008	Biotechnol Appl Biochem2008，49，：	1
5	Temporal pattern of eytotoxie edema in the perihematomal region after in- tracerebral hemorrhage : a serial magnetic resonance imaging study显示文摘	Li N Worthmann H Heeren M	2013	Stroke2013，44，4：	1
6	Aneurysm of the splenic vein显示文摘	Heeren M Op - de - Beeck B Van - den - Brande P	2004	Acta Chir Belg2004，104，3：	1
7	Isolated lung perfusion for pulmonary metastases, a review and work in progress显示文摘	Grootenboers M J Heeren J van Putte BP	2006	Perfusion2006，21，：	1
8	Simple high resolution nanoimprintlithography显示文摘	Haffner M Heeren A Fleischer M Kern D Schmidt G Molenkamp L	2007	Microelectron Eng2007，84，：	1
9	MMI1 (YKL056c,TMA19),the yeast orthologue of the translationally controlled tumor protein(TCTP) has apoptotic functions and interacts with both microtubules and mitochondria显示文摘	Rinnerthaler M Jarolim S Heeren G	2006	Biochim Biophys Acts2006，1757，56：	1
10	Apoprotein A-V: an important regulator of triglyceride metabolism显示文摘	Kluger M Heeren J Merkel M	2008	J Inherit Metab Dis2008，31，2：	1
11	Evaluation of the bank stability and toe erosion model (BSTEM) for predicting later- al retreat on composite streambanks 显示文摘	Midgley T L Fox G A Heeren D M	2012	Geomorphology2012，，145146：	1
12	Extent of preoperative staging in esophageal cancer to prevent futile explorative surgery显示文摘	VAN WESTREENEN H L HEEREN P A M VAN DULLEMEN H M	2004	Gastroentrology2004，126，4：	1
13	Purification and characterization of microbially expressed neomycin phosphotransferase Ⅱ (NPTⅡ) protein and its equivalence to the plant expressed protein显示文摘	FUCHS R L HEEREN R A GUSTAFSON M E	1993	Biotechnology (NY)1993，11，13：	1
14	Aneurysm of the splenic vein显示文摘	Heeren M Op-de-Beeek B Van-den-Brande P	2004	Acta Chir Belg2004，104，3：	1
15	Adverse Events with Radiographic ContrastAgents: Re sults of the SCVIR Contrast Agent Registry显示文摘	Bettmann M A Heeren T Greenfield A	1997	Radiology1997，230，61：	1
16	Imaging mass spectrometry 显示文摘	MCDONNELL L A HEEREN R M A	2007	Mass Spectrom Rev2007，26，4：	1
17	Imaging mass spectrometry 显示文摘	MCDONNELL L A HEEREN R M A	2007	Mass Spectrometry Re- views2007，26，：	1
18	A new,powerful player in lipopro rein metabolism : brown adipose tissue显示文摘	Bartelt A Merkel M Heeren J	2012	J Mol Med (Berl)2012，90，8：	1
19	Influence of temperature on HSQ electron-beam lithography显示文摘	HEEREN A FLEISCHER M PEISERT H	2007	Vac Sci Technol2007，25，6：	1
20	Evaluation of the bank stability and toe erosion model (BSTEM) for predicting lat- eral retreat on composite streambanks 显示文摘	Midgley T L Fox G A Heeren D M	2012	Geomorphology2012，，145146：	1

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