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| 1 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
| 2 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 3 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 4 | Gel-formation in mixtures of hydr ophobically modified potato and high amylopectin potato starch显示文摘 | Fernando E Ortega-Ojeda Helena Larsson Ann-Charlotte Eliasson | 2005 | Carbohydrate Polymers2005，59，： | 1 |
| 5 | Characterisati- on of 19 almond cuhivars on the basis of their free amino acids composition显示文摘 | Helena S L Poveda E G Moya M S P | 1998 | Food Chemistry1998，61，4： | 1 |
| 6 | Evaluation of an aroma similar to that of sparkling wine:Sensory and gas chromatography analyses of fermented grape musts显示文摘 | Maria E O Mamede Helena M A B Cardello Glaucia M Pastore | 2005 | Food Chemistry2005，89，： | 1 |
| 7 | Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers显示文摘 | Helena E Christer T Artursson P | 2003 | Eur J Pharm Sci2003，19，： | 1 |
| 8 | Improvement of tech- nological quality of eucalypt wood by heat treatment in air at 170-200℃显示文摘 | BRUNO E IDALINA D HELENA P | 2007 | Forest Products Journal2007，57，： | 1 |
| 9 | Developmental biology of the pancreas 显示文摘 | Helena E | 2001 | Diabetes2001，50，1： | 1 |
| 10 | The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats显示文摘 | Cátia Lira Do Amaral Rafaela de Barros e Lima Bueno Regislaine Valéria Burim Regina Helena Costa Queiroz Maria de Lourdes Pires Bianchi Lusania Maria Greggi Antunes | 2011 | MutRes-Genetic Toxicology and Environmental Mutagenesis2011，，1： | 1 |
| 11 | A comparison of the rheological properties of wheat flour dough and its gluten prepared by ultracentrifugation显示文摘 | THEOFANIS G HELENA L ANN-CHARLOTTE E | 2004 | Food Hydrocolloids2004，，18： | 1 |
| 12 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 13 | Determination of e rythromycin in gastriejuice and blood plasma by liquid chromatography and electrochemical detection显示文摘 | HELENA T BRITTMARIC E | 1995 | J Chromatogr B1995，673，： | 1 |
| 14 | Clustering of clinical strains of Helicobacter pylori analyzed by two-dimensional gel electrophoresis显示文摘 | Helena E Thomas A Anna S | 2000 | Clinical and Diagnositic Laboratory Immunology2000，7，： | 1 |
| 15 | Gel formation in mixtures of amylose and high amylopectin potato starch显示文摘 | Fernando E Ortega-Ojeda Helena Larsson | 2004 | Carbohydrate Polymers2004，57，： | 1 |
| 16 | Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis 显示文摘 | Heitor S Helena M Natacha E | 2013 | Neuropsychobiology2013，，2： | 1 |
| 17 | Temporal evaluation of grotmdwater composition in an alluvial aquifer (Pisuerga river, Spain) by principal component analysis 显示文摘 | HELENA B PARDO R VEGA M BARRADO E FERNANDEZ J M FERNANDEZ L | 2000 | Water Research2000，34，： | 1 |
| 18 | Multistep electron transfer in palladium - catalyzed aerobic oxidations via a meta; macrocycle -quinone system 显示文摘 | Jan - E Backvall R Bruce Hopkins Helena Grennberg | 1990 | J Am Chem Soc1990，112，： | 1 |
| 19 | Social Capital, Knowledge Acquisition, and Knowledge Exploitation in Young Technology--Based Firms 显示文摘 | HELENA Y AUTIO E SAPIENZA H J | 2001 | Strategic Management Journal2001，，7： | 1 |
| 20 | Mothers'experiences of having theirnewborn child in a neonatal intensive care unit 显示文摘 | Helena W Rene'e J Marie B | 2006 | Scand J Car- ing Sci2006，20，11： | 1 |
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