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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Calibration and validation of DRAINMOD to design subsurface drainage systems for Iowa's tile land- scapes显示文摘 | Singh R Helmers M J Qi Z M | 2006 | Agricultural Water Management2006，85，3： | 1 |
| 3 | Nutrientremoval by prairie filter strips in agricultural landscapes 显示文摘 | Helmers J Asbjornsen H Kolka R | 2014 | Journal of Soil and Water Conservation2014，69，1： | 1 |
| 4 | Variation in water uptakedynamics among contrasting agricultural and native plant communitiesin the Midwestern US显示文摘 | ASBJORNSEN H MORA G HELMERS M J | 2007 | Agriculture ecosystems & environment2007，121，4： | 1 |
| 5 | Supercooling of poly(dimethylsiloxanes)显示文摘 | HELMER J D POLMANTEER K E | 1969 | Journal of Applied Polymer Science1969，13，： | 1 |
| 6 | Vagina nerve stimulation in children withrefractory seizures associated with Lennox - Gastaut syndrome显示文摘 | Frost M Gastes J Helmers | 2001 | Epilepsia2001，42，9： | 1 |
| 7 | Do leuco- cytes reflect condition in nestling burrowing parrots Cyanoliseus patagonus in the wild 显示文摘 | Masello J F Choconi R G Helmer M | 1992 | Comparative Biochemistry and Physiology Part A Molecular Integrative Physiology1992，152，： | 1 |
| 8 | Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1显示文摘 | HELMER K S SULIBURK J W MERCER D W | 2006 | Dig Dis Sci2006，51，： | 1 |
| 9 | Lightweight agents for intrusion detection显示文摘 | Helmer G Wong J S K Honavar V | 2003 | The Journal of Systems and Software2003，67，3： | 1 |
| 10 | Vagus nerve stimulation in children with refractory seizures associated with LennoxGastaut syndrome显示文摘 | Frost M Gates J Helmers SL | 2001 | Epilepsia2001，42，9： | 1 |
| 11 | Surgeon-performed ultrasound for pneumothorax in the trauma suite显示文摘 | Knudtson J L Dort J M Helmer S D | 2004 | J Trauma2004，56，3： | 1 |
| 12 | Ketamine attenuates liver injury attributed to endotoxemia:role of cyclooxygenase-2显示文摘 | SULIBURK J W HELMER K S GONZALEZ E A | 2005 | Surgery2005，138，2： | 1 |
| 13 | Calihration and valida- tion of DRAIN-MOD to design subsurface drainage sys- tems for Iowds tile land-scapes显示文摘 | Singh R Helmers M J Qi Z M | 2006 | Agricultural Water Management2006，85，3： | 1 |
| 14 | Calibration and validation of DRAINMOD to design subsurface drainage systems for Iowa's tile landscapes显示文摘 | Singh R Helmers M J Qi Z M | 2006 | Agricultural Water Management2006，85，3： | 1 |
| 15 | Evaluation of fundamental properties of a silica capillary used for capillary electrophoresis显示文摘 | Salomon K Burgi D S Helmer J C | 1991 | J Chromatogr1991，559，12： | 1 |
| 16 | Predicting ef- fects of drainage water management in Iowa's subsurface drained landscapes显示文摘 | Singh R Helmers M J Crumpton W G | 2007 | Agricultural Water Management2007，92，3： | 1 |
| 17 | CT of the intraeranial cryptocoeosis 显示文摘 | Popovich M J Arthur RH Helmer E | 1990 | AR11990，154，： | 1 |
| 18 | Automated discovery of concise predictive rules for intrusion detection显示文摘 | Wong J Honavar | 2002 | Journal of System and Software2002，60，2： | 1 |
| 19 | Macrosegregation during Bridgman Growth of Ge1-x Si, Mixed Crystals 显示文摘 | Helmers L Schilz J Bahr G | 1995 | Journal of Crystal Growth1995，，154： | 1 |
| 20 | A design aid for determining width of filter strips显示文摘 | DOSSKEY M G HELMERS M J EISENHAUER D E | 2008 | Journal of Soil and Water Conservation2008，63，4： | 1 |
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