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| 1 | Zircon Ce^4+/Ce^3+ ratios and ages for Yulong ore-bearing por- phyries in eastern Tibet显示文摘 | Liang Huaying Campbell I H Allen C Sun Weidong Liu Congqiang Yu Hengxiang Xie Yingwen Zhang Yuqiang | 2006 | Miner Deposita2006，41，2： | 1 |
| 2 | A study of dilatational rheological properties of polymer at interfaces 显示文摘 | CAO Xulong LI Yang JIANG Hengxiang | 2004 | Journal of Colloid and Interface Science2004，，2： | 1 |
| 3 | Co-transfusion of haplo-identical hematopoietic and mesenchymal stem cells to treat a patient with severe aplastic显示文摘 | Hengxiang W Zhidong W Mei X | 2010 | Cytotherapy2010，12，4： | 1 |
| 4 | Research on effect of rare earth compounds in phosphating process显示文摘 | Zhu Hengxiang Pang Xijie | 2004 | Journal of Rare Earths2004，22，： | 1 |
| 5 | Geochemistry and tectonic enviromnent of the Dazhuka ophiolite from the Yarlung Zangbosuture, Tibet, China显示文摘 | Xia Bin Yu Hengxiang Chen Genwen | 2003 | Geochemical Journal2003，37，： | 1 |
| 6 | Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells显示文摘 | Jing Liu Dongmei Han Zhidong Wang Mei Xue Ling Zhu Hongmin Yan Xiaoli Zheng Zikuan Guo Hengxiang Wang | 2013 | Cytotherapy2013，，2： | 1 |
| 7 | Linkage and mapping analyses of the densonucleosis non-susceptible gene nsd-Z in the silkworm Bombyx mori using SSR markers显示文摘 | Muwang Li Qiuhong Guo hengxiang Hou Xuexia Mia etal | 2006 | Genome2006，49，： | 1 |
| 8 | Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that progressed from non-severe acquired aplastic anemia显示文摘Severe aplastic anemia II(SAA-II)progresses from non-severe aplastic anemia(NSAA).The unavailability of efficacious treatment has prompted the need for haploidentical bone marrow transplantation(haplo-BMT)in patients lacking a human leukocyte antigen(HLA)-matched donor.This study aimed to investigate the efficacy of haplo-BMT for patients with SAA-II.Twenty-two patients were included and followed up,and FLU/BU/CY/ATG was used as conditioning regimen.Among these patients,21 were successfully engrafted,19 of whom survived after haplo-BMT.Four patients experienced grade II–IV aGvHD,including two with grade III–IV aGvHD.Six patients experienced chronic GvHD,among whom four were mild and two were moderate.Twelve patients experienced infections during BMT.One was diagnosed with post-transplant lymphoproliferative disorder and one with probable EBV disease,and both recovered after rituximab infusion.Haplo-BMT achieved 3-year overall survival and disease-free survival rate of 86.4%±0.73%after a median follow-up of 42 months,indicating its effectiveness as a salvage therapy.These promising outcomes may support haplo-BMT as an alternative treatment strategy for patients with SAA-II lacking HLA-matched donors. | Hongchen Liu Xiaoli Zheng Chengtao Zhang Jiajun Xie Beibei Gao Jing Shao Yan Yang Hengxiang Wang Jinsong Yan | 2021 | Frontiers of Medicine2021，15，5： | 1 |
| 9 | SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation显示文摘Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of melanocyte.While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still suboptimal.During tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment.SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell homeostasis.Nevertheless,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains elusive.Herein,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.We first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon stress.Then,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in vivo.Mechanistically,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting cytokines.SIRT7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 axis.Moreover,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 axis.Additionally,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also investigated.Taken together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy. | Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang Zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu Zhang Lili Wu Qiong Shi Tianwen Gao Weinan Guo Chunying | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 10 | The effect of deposition conditions on structure properties of radio frequency reactive sputtered polycrystalline ZnO films 显示文摘 | Gong Hengxiang Wang Yinyue Yan Zhijun | 2002 | Materials Science in Semiconductor Processing2002，5，1： | 1 |
| 11 | Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells显示文摘 | Han Dongmei Liu Jing Xue Mei Zhu Ling Yan Hongmin Wang Zhidong Ding Li Guo Zikuan Wang Hengxiang | 2011 | Cytotherapy2011，，8： | 1 |
| 12 | Research on effect of rare earth compounds in phosphating process显示文摘 | Kuang juchi Zhu hengxiang Pang xijie | 2004 | Journal of Rare Earths2004，22，： | 1 |
| 13 | 显示文摘 | Gong Hengxiang Wang Yinyue Yan Zhijun | 2002 | Materials Science in Semiconductor Processing2002，5，： | 1 |
| 14 | 显示文摘 | Gong Hengxiang Wang Yinyue Yan Zhijun | 2002 | Materials Science in Semiconductor Processing2002，5，： | 1 |
| 15 | Co-transfusion of haplo-identical hematopoietic and mesenchymal stromal cells to treat a patient with severe aplastic显示文摘 | Hengxiang W Zhidong W Xue M | 2010 | Cytotherapy2010，12，4： | 1 |
| 16 | Geochemistry of basalts :Evidence for formation of Dazhu ophiolite, Tibet (China), in a supra-subduction zone environment 显示文摘 | Xia Bin Yu Hengxiang Mei Houjun | 2003 | Journal of the Geological Society of India2003，61，： | 1 |
| 17 | Structure and chain conformation of a (1→6)-α- d -glucan from the root of Pueraria lobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative显示文摘 | Hengxiang Cui Qin Liu Yongzhen Tao Hongfeng Zhang Lina Zhang Kan Ding | 2008 | Carbohydrate Polymers2008，，4： | 1 |
| 18 | A study of dilational rheological properties of polymer at interfaces显示文摘 | Cao Xulong Li Yang Jiang Hengxiang | 2004 | Colloid Surf A2004，12，2： | 1 |
| 19 | Mercury distribution, speciation and bioavailability in sediments from the Pearl River Estuary, Southern China 显示文摘 | YU Xiujuan LI Hengxiang PAN Ke | 2012 | Marine Pollution Bulletin2012，64，： | 1 |
| 20 | Structure,ligands,and roles of GPR126/ADGRG6 inthedevelopment and diseases显示文摘Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix interactions.The adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized aGPCRs.GPR126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and mammals.Current studies have extended our understanding of GPR126-mediated roles during develop-ment and in human diseases.In this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases. | Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong | 2024 | Genes & Diseases2024，11，1： | 0 |
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