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| 1 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 2 | Arthroscopic meniscal repair using an exogenous fibrin clot显示文摘 | Henning CE Lynch MA Yearout KM | 1990 | Clin Orthop Relat Res1990，，252： | 1 |
| 3 | Lung infections and innate host defense 显示文摘 | Valdivia-Arenas MA Amer A Henning LN | 2007 | Drug Discov Today Dis Mech2007，4，2： | 1 |
| 4 | Preadmission quality of life can predict mortality in intensive care unit-a prospective cohort study显示文摘 | Bukan RI Mèller AM Henning MA | 2014 | J Crit Care2014，29，6： | 1 |
| 5 | Effect of brain irradiation on blood cerebrospinal fluid barrier permeability of chemotherapeutic agents显示文摘 | Qin DX Ma JL Hen JK | 1997 | Eur J Radiat Oocol1997，43，2： | 1 |
| 6 | Arthroscopic meniscal repair using an exogenous fibrin clot显示文摘 | Henning CE Lynch MA Yearout KM | | 0，，252： | 1 |
| 7 | Dysregulation of HSG triggers vascula Fproliferative disorders显示文摘 | C hen KH Guo X Ma D | 2004 | Nat Cell Bid2004，6，9： | 1 |
| 8 | Hygroscopic properties of aerosol particles at high relative humidity and their diurnal variations in the North China Plain显示文摘 | Liu P. F. Zhao C. S. G?bel T. Hallbauer E. Nowak A. Ran L. Xu W. Y. Deng Z. Z. Ma N. Mildenberger K. Henning S. Stratmann F. Wiedensohler A | 2011 | Atmospheric Chemistry and Physics2011，，224： | 1 |
| 9 | Arthroscopic meniscal repair using an exogenous fibrin clot显示文摘 | Lynch MA Yearout KM | 1990 | Clin Orthop1990，252，： | 1 |
| 10 | Arthroscopic meniscalrepair using an exogenous fibrin clot显示文摘 | Henning CE Lynch MA Yearout KM | 1990 | Clin Orthop Relat Res1990，，： | 1 |
| 11 | Quality of life:international and domestic students studying medi- cine in New Zealand 显示文摘 | Henning MA Krageloh C Moir F | 2012 | Perspectives on Medical Education2012，1，3： | 1 |
| 12 | lx)cal eolTOSiOe hehaviour of hybrid laser-MIG welded AI - Zn - Mg alloy joints显示文摘 | Yan S 1t (hen H Ma C P | 2015 | Materi- als and Design2015，88，： | 1 |
| 13 | Dorsal plating for displanced intra-articular fractures of the distal radius 显示文摘 | Hen'on M Faraj A Craigen MA | 2003 | Injure2003，34，7： | 1 |
| 14 | NR2B-dependent plasticity of adultdoom granule cells is necessary for context discrimination 显示文摘 | Kheirbek MA Tannenholz L Hen R | 2012 | J Neu- rosci2012，32，25： | 1 |
| 15 | Association study offour va- riants in KCNQI with type 2 diabetes mellitus and premature coronary artery disease in aChinese population显示文摘 | HEN Z ZHANG X MA G | 2010 | Mol Bid Rep2010，37，2： | 1 |
| 16 | Actue ligamentous diastasis of the ankle without fracture:Evaluation by radionuclide imaging显示文摘 | Lynch MA Henning CE | 1986 | Am J Sports Med1986，14，： | 1 |
| 17 | Tissue distribution of the multidrug resistance protein显示文摘 | Hens MJ Zaman GJR Izquierdo MA | 1996 | Am J Pathol1996，148，4： | 1 |
| 18 | Actue ligamentous diastasis of the ankle without fracture:Evaluation by radionuclide imaging显示文摘 | Marymont JV Lynch MA Henning CE | 1986 | Am J Sports Med1986，14，： | 1 |
| 19 | 显示文摘 | Pasco JA Hen~ MJ Kotowicz MA | 2001 | J Clin Endocrinol Met2001，86，5： | 1 |
| 20 | Biomechanical comparison of po-lyaxial and uniaxial locking plate fixation in a proximal tibial gapmodel显示文摘 | Cu Hen AB Curtiss S Lee MA | 2009 | J Orthop Trauma2009，23，7： | 1 |
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