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| 1 | Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization显示文摘临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那 probiotic。这里,我们在过敏促进感受性上分析了三选择乳杆菌紧张的 immunomodulatory 性质和他们的混合的影响赌 1 用一只 gnotobiotic 老鼠建模的 v。我们显示出那乳杆菌(L.) rhamnosus LOCK0900, L。rhamnosus LOCK0908 和 L。casei LOCK0919 经由像使用费的受体被认出 2 (TLR2 ) 并且核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产 cytokines 的导出髓的树枝状的房间。殖民无菌(GF ) 有所有三紧张(Lmix ) 的混合物的鼠标由加强 enterocytes 的顶端的 junctional 建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与 Lmix 开拓殖民地于并且敏化 1 变应原到赌注 v 的老鼠显著地象一个增加的转变生长因素(TGF ) 一样在 sera 和肠的 lavages 显示出变应原特定的 IgE, IgG1 和 IgG2a 和提高的全部的 IgA 水平的底层 -β与敏化的 GF 老鼠相比铺平。从开拓殖民地于 Lmix 的老鼠的 Splenocytes 和 mesenteric 淋巴节点房间显示出 TGF-β 的重要 upregulation;在以后在有赌注 v 的 vitro 刺激 1。我们的结果证明 Lmix 殖民改进了内脏对赌注 v 的上皮的障碍和减少的过敏促进感受性 1。而且,这些调查结果被传播和能分泌的 IgA 和规章的 cytokine TGF-β 的增加的生产伴随;。因此,三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。 | Hana Kozakova Martin Schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 2 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 3 | Prognostic significance of antiapoptosis proteins survivin and bcl-2 in nonsmall cell lung carcinomas:a clinicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 4 | Nestin expression in os-teosarcomas and derivation of nestin/CD133 positive osteosarcoma celllines显示文摘 | Veselska R Hermanova M Loja T | | 0，，： | 1 |
| 5 | Prognostic significance of anti-apoptosis proteins survivin and BcL-2 in non-small cel lung carcinomas: a clinicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 6 | Serum levels of the MCP-1 chemokine in patients with ischemic stroke and myocardial infarction显示文摘 | Arakelyan A Petrkova J Hermanova Z | 2005 | Mediators Inflamm2005，3，： | 1 |
| 7 | Prognostic significance of anti- apoptosis proteins surviving and bcl -2 in non -small cell lung carcinomas: a cllnicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 8 | Serum levels of the MCP-1 chemokine in patients with ischemic stroke and myocardial infarction显示文摘 | Arakelvan A Petrkova J Hermanova Z | 2005 | Mediators Inflamm2005，3，： | 1 |
| 9 | An unusual case of congenital muscular dystrophy with normal serum CK level, external ophtalmoplegia, and white matter changes on brain MRI显示文摘 | Vondracek P Hermanova M Vodickova K | 2007 | European Journal Of Paediatic Neurology2007，11，6： | 1 |
| 10 | Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas:a clinicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 11 | The levels of sCD30 and of sCIMOL in a group of patients with systemic lupus erythematodes and their diagnostic value显示文摘 | Ciferska H Hor6k P Hermanova Z | 2007 | Clin Rheumato12007，26，5： | 1 |
| 12 | An unusual case of congenital muscular dystrophy with normal serum CK level, external ophtalmoplegia, and white matter changes on brain MRI 显示文摘 | Vondracek P Hermanova M Vodickova K | 2007 | Eur J Paediatr Neurol2007，11，6： | 1 |
| 13 | Nestin expression in osteosareomas and derivation of nestin/CDis3 positive osteosareoma cell lines显示文摘 | Veselska R Hermanova M l oja T | 2008 | BMC Cancer2008，8，： | 1 |
| 14 | Prognostic signmcance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas:a clinicopathologic studyof 102 cases显示文摘 | Kren L Brazdil J Hermanova M et a1 | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 15 | Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas 显示文摘 | LEOS KREN JAN BRAZDIL MARKETA HERMANOVA | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 16 | Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1)显示文摘 | Hermanova M Lukas Z Nenutil R | 2004 | Neoplasma2004，51，2： | 1 |
| 17 | Prognostic significance of anti-apoptosis proteins surviving and bcl-2 in non-small lung carcinomas: a clinicopathologic study of 102 cases显示文摘 | Kren L Branzdil L Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，： | 1 |
| 18 | Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas :a clinicopathologic study of 102 cases 显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 19 | Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas l a clinicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Appl Immunohistochem Mol Moropho2004，12，1： | 1 |
| 20 | Prognostic significance of anti-apoptosis proteins survivin and bcl 2 in nonsmall cell lung carcinomas: a clinicopathologic study of 102 cases显示文摘 | Kren L Brazdil J Hermanova M | 2004 | Aoppl Immunohistochem Mol Morphol2004，19，1： | 1 |
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