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| 1 | Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review显示文摘AIM To synthesize the available evidence focusing on morbidities in pediatric survivors of critical illness that fall within the defined construct of postintensive care syndrome(PICS) in adults, including physical, neurocognitive and psychological morbidities.METHODS A comprehensive search was conducted in MEDLINE, EMBASE, the Cochrane Library, Psyc INFO, and CINAHL using controlled vocabulary and key word terms to identify studies reporting characteristics of PICS in pediatric intensive care unit(PICU) patients. Two reviewers independently screened all titles and abstracts and performed data extraction. From the 3176 articles identified in the search, 252 abstracts were identified for full text review and nineteen were identified for inclusion in the review. All studies reporting characteristics of PICS in PICU patients were included in the final synthesis. RESULTS Nineteen studies meeting inclusion criteria published between 1995 and 2016 were identified and categorized into studies reporting morbidities in each of three categories-physical, neurocognitive and psychological. The majority of included articles reported prospective cohort studies, and there was significant variability in the outcome measures utilized. A synthesis of the studies indicate that morbidities encompassing PICS are well-described in children who have survived critical illness, often resolving over time. Risk factors for development of these morbidities include younger age, lower socioeconomic status, increased number of invasive procedures or interventions, type of illness, and increased benzodiazepine andnarcotic administration.CONCLUSION PICS-related morbidities impact a significant proportion of children discharged from PICUs. In order to further define PICS in children, more research is needed using standardized tools to better understand the scope and natural history of morbidities after hospital discharge. Improving our understanding of physical, neurocognitive, and psychological morbidities after critical illness in the pediatric population is imperative for designing interventions to improve long-term outcomes in PICU patients. | Elizabeth A Herrup Beth Wieczorek Sapna R Kudchadkar | 2017 | World Journal of Critical Care Medicine2017，6，2： | 7 |
| 2 | the Induction of Multiple Cell Cycle Events Precedes Target-related Neuronal Death显示文摘 | HERRUP K BUSSER JC | 1995 | Development(S0890- 9369)1995，121，8： | 1 |
| 3 | Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease显示文摘 | Yang Y Mufson EJ Herrup K | 2003 | J Neurosci2003，23，7： | 1 |
| 4 | Divide and die: cell cycle events as triggers of nerve cell death显示文摘 | Herrup K Neve R Ackerman SL | 2004 | J Neurosci2004，24，42： | 1 |
| 5 | Commissioning a passive-scattering proton therapy nozzle for accurate SOBP delivery 显示文摘 | Engelsman M Lu HM Herrup D | 2009 | Med Phys2009，36，6： | 1 |
| 6 | MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists 显示文摘 | Bagchi A Herrup Warren EA | 2007 | J Immunol2007，178，2： | 1 |
| 7 | DNA replication precedes neuronal cell death in Alzheimers disease显示文摘 | Yang Y Geldmacher D S Herrup K | 2001 | J Neurosci2001，21，8： | 1 |
| 8 | Reimagining Alzheimer 's disease--an age-based hypothesis显示文摘 | Herrup K | 2010 | The Journal of neuroseiance2010，30，50： | 1 |
| 9 | Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in rnGluR1 mutant mice显示文摘 | Aiba A Chert C Herrup K | 1994 | Cell1994，79，： | 1 |
| 10 | Reimagining Alzheimer' s Disease-An Age-Based Hypothesis显示文摘 | Herrup K | | 0，，50： | 1 |
| 11 | Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the EN2 homeobox 显示文摘 | Herrup K Auerbach B A | 1991 | Sci1991，251，： | 1 |
| 12 | The control of neuron number显示文摘 | WILLIAMS R W HERRUP K | 1988 | Annu Rev Neurosci1988，11，： | 1 |
| 13 | Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differen-tiation显示文摘 | CICERO S HERRUP K | 2005 | Neurosci2005，25，42： | 1 |
| 14 | Reimagining Alzheimer’s disease-An age-based hypoth-esis显示文摘 | Herrup K | 2010 | J Neurosci2010，30，16： | 1 |
| 15 | Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma:clinical outcomes and dosimetry compared to intensity-modulated radiation therapy显示文摘 | Cotter SE Herrup DA Friedmann A | | 0，，05： | 1 |
| 16 | Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies 显示文摘 | Zwingman T Li R Pan T Wong BS Peterson RB Gambetti P Herrup K Sy MS | 2001 | Brain Res2001，896，12： | 1 |
| 17 | Cyelin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation 显示文摘 | Cicero S Herrup K | 2005 | J Neurosci2005，25，42： | 1 |
| 18 | Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease显示文摘 | Yang Y Mufson EJ Herrup K | 2003 | J Neurosci2003，23，7： | 1 |
| 19 | MyD88-dependent and MyD88-independent pathways in synergy,priming,and tolerance between TLR agonists显示文摘 | Herrup EA Warren HS | 2007 | J Immunol2007，178，： | 1 |
| 20 | Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain显示文摘 | Geldmacher D S Herrup K | 1998 | J Neurosci1998，18，8： | 1 |
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