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481篇 您的检索式:作者名="Hishikawa"
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1Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases显示文摘The gene encoding bone morphogenetic protein-7(BMP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BMP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BMP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BMP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BMP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BMP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BMP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases.Taro Tsujimura Mana Idei Masahiro Yoshikawa Osamu Takase Keiichi Hishikawa 2016World Journal of Stem Cells2016,8,9:6
2Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma显示文摘Few potentially curative treatment options exist apart from hepatic resection for patients with huge hepatocellular carcinoma (HCC). Proton radiotherapy is a promising new modality which has an inherent antitumor effect against HCC. However, the application of proton radiotherapy for tumors adjacent to the gastrointestinal tract is restricted because the tolerance dose of the intestine is extremely low. A novel two-step treatment was developed with surgical spacer placement and subsequent proton radiotherapy to administer proton radiotherapy with curative intent. This report presents a case of a patient with a huge unresectable HCC treated by this method who achieved disease-free survival of more than 2 years. This new strategy may potentially be an innovative and standard therapy for unresectable HCC in the near future.Shohei Komatsu Yuichi Hori Takumi Fukumoto Masao Murakami Yoshio Hishikawa Yonson Ku 2010World Journal of Gastroenterology2010,16,14:5
3Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma显示文摘Shohei Komatsu Takumi Fukumoto Yusuke Demizu Daisuke Miyawaki Kazuki Terashima Ryohei Sasaki Yuichi Hori Yoshio Hishikawa Yonson Ku Masao Murakami 2011Cancer2011,,21:2
4Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells显示文摘Keiichi Hishikawa Toshio Nakaki Tomoko Fujii 2000European Journal of Pharmacology2000,,1:1
5Solar cell efficiency ta- bles显示文摘Green M A Emery K Hishikawa Y 2012Res Appl2012,20,:1
6Static pressure regulates connective tissue growth factor expression in human angial cells显示文摘Hishikawa K Oemar BS Nakik T 2001J Biol Chem2001,276,16:1
7Solar cell efficiency tables (Version 38) 显示文摘Green M A Emery K Hishikawa Y 2011Prog Photovolt: Res Appl2011,19,:1
8Vapor phase preparation and some properties of carbon micro-coils/nano-coils显示文摘Motojima S Hishikawa Y Iwanaga H 2002Recent Res Devel Mat Sci2002,,3:1
9Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells显示文摘Watabe M Hishikawa K Takayanagi A 0,,07:1
10Solar cell efficiency ta-bles(version 41)显示文摘Martin A Green Keith Emery Yoshihiro Hishikawa Wil-helm Warta and Ewan D Dunlop 0,,:1
11Differentiating progressive supranuclear palsy from Parkinson's disease by MRI-based dynamic cerebrospinal fluid flow显示文摘Fukui Y Hishikawa N Sato K 2015J Neurol Sci2015,357,12:1
12Solar cell effi- ciency tables (version 36) 显示文摘Green M A Emery K Hishikawa Y 2010Progr Photovoltaics2010,18,5:1
13Germ cell apoptosis and its molecular trigger in mouse testes显示文摘Koji T Hishikawa Y 2003Arch Histol Cytol2003,66,1:1
14Improvement of in situ PCR by optimization of PCR cycle number and proteinase k concentration:localization of x chromosomelinked phosphoglycerate kinase-1 gene in mouse reproductive organs显示文摘HISHIKAWA Y AN S YAMAMOTO-FUKUDA T 2009Acta Histochem Cytochem2009,42,2:1
15Pulsatile stretch stimulates superoxide production and activates nuclear factor-kappa β in human coronary smooth muscle显示文摘Hishikawa K Oemar BS Yang Z 0,,:1
16Connective tissue growth factor induces apoptosis via caspase 3 in cultured hunman aortic smooth muscle cells显示文摘Hishikawa K Nakaki T Fujii T 2000Eur J Pharmacol2000,392,12:1
17Expression of metallothionein in colorectal cancers and synchronous liver metastases显示文摘Hishikawa Y Kohno H Ueda S 2001Oncology2001,61,2:1
18Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types 显示文摘An S Hishikawa Y Koji T 2005Histoehem Cell Biol2005,123,3:1
19Connective tissue growth factor induce apoptosis via Caspase -3 in culturel human aortic smooth muscle cells 显示文摘Hishikawa K Nakaki T Fujii T 2000Eur J Pharmacol2000,392,12:1
20Connective tissue growth factor in- duce apoptosis via Caspase-3 in cuhurel human aortic smooth muscle cells 显示文摘Hishikawa K Nakaki T Fujii T 2000Eur J Pharmacol2000,392,12:1
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