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| 1 | Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis显示文摘AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA monotherapy.RESULTS In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in patients with a serum ALT level of 200 IU/L or lower. | Yuichi Torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki Saruta Mikio Zeniya | 2017 | World Journal of Hepatology2017，9，1： | 3 |
| 2 | An antioxidant resveratrol significantly enhanced replication of hepatitis C virus显示文摘AIM:To elucidate the effect of antioxidants,resveratrol (RVT)and astaxanthin(AXN),on hepatitis C virus(HCV) replication. METHODS:We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6.RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses.AXN is also a strong antioxidant.The replication of HCV RNA was assessed by the luciferase reporter assay.An additive effect of antioxidants on antiviral effects of interferon(IFN)and ribavirin(RBV) was investigated.RESULTS:This is the first report to investigate the effect of RVT and AXN on HCV replication.In contrast to other reported viruses,RVT significantly enhanced HCV RNA replication.Vitamin E also enhanced HCV RNA replication as reported previously,although AXN didnot affect replication.IFN and RBV significantly reduced HCV RNA replication,but these effects were dose-dependently hampered and attenuated by the addition of RVT.AXN didnot affect antiviral effects of IFN or RBV. CONCLUSION:These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C. | Mitsuyasu Nakamura Masanori Ikeda Ryota Hokari Nobuyuki Kato Toshifumi Hibi Soichiro Miura | 2010 | World Journal of Gastroenterology2010，16，2： | 3 |
| 3 | A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells显示文摘 | Toshiaki Teratani Kengo Tomita Takahiro Suzuki Tetsuya Oshikawa Hirokazu Yokoyama Katsuyoshi Shimamura Susumu Tominaga Sadayuki Hiroi Rie Irie Yoshikiyo Okada Chie Kurihara Hirotoshi Ebinuma Hidetsugu Saito Ryota Hokari Kazuo Sugiyama Takanori Kanai Soich | 2012 | Gastroenterology2012，，1： | 2 |
| 4 | Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘 | Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 5 | Efficacy of MK615 for the treatment of patients with liver disorders显示文摘AIM:To investigate the hepatoprotective effect of MK615,a Japanese apricot extract,in an animal model,and its clinical therapeutic effect.METHODS:Wistar rats were administered physiological saline(4 mL/kg) or MK615 solution(4 mL/kg) for 7 d.On the sixth d,acute hepatic injury was induced by administering a single intraperitoneal injection(ip) of D-galactosamine hydrochloride(D-GalN)(600 mg/kg).Plasma levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were determined,and liver tissues were used for histopathological analysis.Fifty-eight patients with liver disorders [hepatitis C(n = 40),non-alcoholic fatty liver disease(n = 15),and autoimmune liver disease(n = 3)] were orally administered commercially available Misatol ME-containing MK615(13 g/d) daily for 12 wk.Blood and urine were sampled immediately before and 6 wk,12 wk,and 16 wk after the start of intake to measure various biochemical parameters.The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint.RESULTS:D-GalN effectively induced acute hepatic injury in the rats.At 48 h after the ip injection of D-GalN,the plasma levels of ALT(475.6 ± 191.5 IU/L vs 225.3 ± 194.2 IU/L,P < 0.05) and AST(1253.9 ± 223.4 IU/L vs 621.9 ± 478.2 IU/L,P < 0.05) in the MK615 group were significantly lower than the control group.Scattered single cell necrosis,loss of hepatocytes,and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group.However,these findings were less pronounced in the group receiving MK615.At the end of the clinical study,serum ALT and AST levels were significantly decreased compared with pre-intake baseline levels from 103.5 ± 58.8 IU/L to 71.8 ± 39.3 IU/L(P < 0.05) and from 93.5 ± 55.6 IU/L to 65.5 ± 34.8 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 26(45%) of the 58 patients,while 25(43%) patients exhibited similar AST level reductions.The chronic hepatitis C group exhibited significant ALT and AST level reductions from 93.4 ± 51.1 IU/L to 64.6 ± 35.1 IU/L(P < 0.05) and from 94.2 ± 55.5 IU/L to 67.2 ± 35.6 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 20(50%) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid(UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration.MK615 protected hepatocytes from D-GalN-induced cytotoxicity in rats.Misatol ME decreased elevated ALT and AST levels in patients with liver disorders.CONCLUSION:These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders. | Atsushi Hokari Tomohisa Ishikawa Hisao Tajiri Takahide Matsuda Osamu Ishii Nobuyuki Matsumoto Chiaki Okuse Hideaki Takahashi Takeshi Kurihara Ko-ichi Kawahara Ikuro Maruyama Mikio Zeniya | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 6 | Altered migration of gut-derived T lymphocytes after activation with concanavalin A显示文摘 | Hokari R Miura S Fujimori H | 1999 | Am J Physiol1999，277，41： | 1 |
| 7 | Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis:roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP) 显示文摘 | Nakajima Y Yamagishi T Hokari S | 2000 | Anat Rec2000，258，2： | 1 |
| 8 | Improvement of cerebral hemodynamic and metabolic parameters in a patient who presented intracranial hypertension due to superior sinus thrombosis after lumbo-peritoneal shunt: case report 显示文摘 | Hokari M Kuroda S Ishikawa T | 2005 | No Shinkei Geka2005，33，3： | 1 |
| 9 | 显示文摘 | TACHKAWA H HOKARI N YOSHIDA H | 1995 | Chem Phys Lett1995，241，2： | 1 |
| 10 | Efficacy of triple therapy with raheprazole for Helicohacter pylori infection and CYP2C19 genetic polymorphisism 显示文摘 | Hokari K Sugiyama T Kato M | 2001 | Aliment Phar macol Ther2001，15，14： | 1 |
| 11 | Increased expression of galectin-3 in primary gastric cancer and themetastatic lymph nodes显示文摘 | Junichi Miyazaki Ryota Hokari Shingo Kato Yoshikazu Tsuzuki Atushi Kawaguchi Shigeaki Nagao Kazuro Itoh Soichiro Miura | 2002 | Oncology Reports2002，，6： | 1 |
| 12 | Increased expression of ga- lectin -3 in primary gastric cancer and the metastatic lymph nodes 显示文摘 | Miyazaki J Hokari R Kato S | 2002 | Oncol Rep2002，9，6： | 1 |
| 13 | Bile acid reguhtes MUC2 transcription in colon caner cells via positive EGFR/PKC/Ras/ERK/CREB,PI3K/Akt/Ikappa B and p38/MSKI/CREB pathways and negative JNK/c-Jun/AP-1 pathway显示文摘 | Lee HY Crawley S Hokari R et a1 | 2010 | Int JOnco I2010，36，4： | 1 |
| 14 | Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model显示文摘 | Okudaira K Hokari R Tsuzuki Y | 2009 | Int J Oncol2009，35，4： | 1 |
| 15 | Efficacy of triple ther- apy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism显示文摘 | Hokari K Sugiyama T Kato M | 2001 | Aliment Pharmacol T- her2001，15，9： | 1 |
| 16 | Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF) beta and bone morphogenetic protein ( BMP) 显示文摘 | NAKAJIMA Y YAMAGISHI T HOKARI S | 2000 | Anat Rec2000，258，2： | 1 |
| 17 | Increased expression of galectin-3 in primary gastric cancer and the metastatic lymph nodes显示文摘 | Miyazaki J Hokari R Kato S | 2002 | Oncol Rep2002，9，6： | 1 |
| 18 | Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model显示文摘 | Okudaira K Hokari R Tsuzuki Y | 2009 | Int J Onco12009，35，4： | 1 |
| 19 | The Steffee variable screw placement system using different methods of bone grafting显示文摘 | Yashiro K Homma T Hokari Y | 1991 | Spine1991，16，： | 1 |
| 20 | Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms 显示文摘 | Hokari M Kuroda S Shichinohe H Yano S Hida K Iwasaki Y | 2008 | Neurosci Res2008，86，5： | 1 |
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