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您的检索式：作者名="Holger Stark"
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| 1 | Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis显示文摘Cytochromes P450 s(CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. About 80% of currently used drugs and environmental chemicals comprise exogenous substrates for CYPs. Genetic polymorphisms of CYPs may affect the enzyme functions and have been reported to be associated with various diseases and adverse drug reactions among different populations. In this review, we discuss the role of some critical CYP isoforms(CYP1 A1, CYP2 D6, CYP2 J2, CYP2 R1,CYP3 A5, CYP3 A7, CYP4 F3, CYP24 A1, CYP26 B1 and CYP27 B1) in the pathogenesis or aetiology of ulcerative colitis concerning gene polymorphisms. In addition, their significance in metabolism concerning ulcerative colitis in patients is also discussed showing a clear underestimation in genetic studies performed so far. | Alaattin Sen Holger Stark | 2019 | World Journal of Gastroenterology2019，25，23： | 4 |
| 2 | Miniaturization of a coherent monocular structured illumination system for future combination with digital holography显示文摘Holographic and 3D-measurement processes are an often-used tool in industry,medicine,and scientific applications.While small deviations of objects can be visualized by holographic means with high accuracy,optical systems with active structured illumination are a reliable source of absolute 3D-information in these fields.The combination of digital holography with structured illumination allows to simultaneously measure deformations and absolute 3D coordinates but also requires coherent light and has already been demonstrated in principle with a stereo camera setup.Multi-camera systems are limited to certain setup sizes given by the volume and distance of the detectors.Reducing the system to a one-camera(monocular)setup reduces space and acquisition costs.By using a multi-aperture illumination source an extremely high projection rate could be realized and reduced to a monocular approach with a novel voxel-calibration technique,while the projection system itself still requires a large amount of space.In this paper we present a miniaturized,monocular 3D-measurement system that works with repeatable,coherent speckles,generated by a fiber-coupled laser whose light was distributed by a fiber-switch to a diffuser plate connected with a measurement-head,also including a camera.By addressing different fibers through the switch,varying but repeatable patterns are generated.The size of the device(diameter<3 cm)is now mainly limited by the volume of the camera.A first 3D-reconstruction of an object and an outlook for a combination of this system with digital holography is given,allowing absolute 3D-coordinates and relative deviations of object points to be measured simultaneously. | Andreas Walter Stark Eugene Wong Holger Babovsky Christian Franke Richard Kowarschik | 2022 | Light(Advanced Manufacturing)2022，3，3： | 0 |
| 3 | 布隆伯格为彭博社动手术显示文摘纽约前任市长布隆伯格卸任之后在做什么?德国《明镜》周刊刊文称,他重新回到自己的商业帝国,着手进行一项激进的改革。12年来,布隆伯格一直管理着这个世界上最重要的城市之一纽约。卸任后,似乎已经没有什么职位可以满足他了。世行总裁?联合国秘书长? | Isabell Huelsen Holger Stark 津田 | 2016 | 看世界2016，0，1： | 0 |
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