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| 1 | Characteristics of motorized spindle supported by active magnetic bearings显示文摘A motorized spindle supported by active magnetic bearings(AMBs) is generally used for ultra-high-speed machining. Iron loss of radial AMB is very great owing to high rotation speed, and it will cause severe thermal deformation. The problem is particularly serious on the occasion of large power application, such as all electric aero-engine. In this study, a prototype motorized spindle supported by five degree-of-freedom AMBs is developed. Homopolar and heteropolar AMBs are independently adopted as radial bearings. The influences of the two types of radial AMBs on the dynamic characteristics of the motorized spindle are comparatively investigated by theoretical analysis, test modal analysis and actual operation of the system. The iron loss of the two types of radial AMBs is analyzed by finite element software and verified through run-down experiments of the system. The results show that the structures of AMB have less influence on the dynamic characteristics of the motorized spindle. However, the homopolar structure can effectively reduce the iron loss of the radial AMB and it is useful for improving the overall performance of the motorized spindle. | Xie Zhenyu Yu Kun Wen Liantang Wang Xiao Zhou Hongkai | 2014 | Chinese Journal of Aeronautics2014，27，6： | 6 |
| 2 | Movement behavior of a spider on a horizontal surface显示文摘Studying the locomotive behavior of animals has the potential to inspire the design of the mechanism and gait patterns of robots ('bio-inspired robots'). The kinematics characteristics of a spider (Ornithoctonus huwena), including movement of the legs, movement of the center of mass (COM) and joint-rotation angle, were obtained from the observation of locomotion behaviors recorded by a three-dimensional locomotion observation system. Our results showed that one set of the stance phase consists of four legs, which were leg-1 and leg-3 on one side and leg-2 and leg-4 on the other side. Additionally, two sets of the stance phase comprised eight legs alternately supporting and driving the motion of the spider's body. The spider primarily increased its movement velocity by increasing stride frequency. In comparison to other insects, the spider, O. huwena, has superior movement stability. The velocity and height of COM periodically fluctuated during movement, reaching a maximum during alternation of leg phase, and falling to a minimum in the steady stance phase. The small change in deflection angle of the hind-leg was effective in driving locomotion, whereas each joint-rotation angle of the fore-leg changed irregularly during locomotion. This research will help in the design of bio-inspired robots, including the selection of gait planning and its control. | WANG ZhouYi WANG JinTong JI AiHong LI HongKai DAI ZhenDong | 2011 | Chinese Science Bulletin2011，56，25： | 5 |
| 3 | Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening显示文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research. | Qiangqiang Tang Xiaoyu Li Chen Lai Lei Li Hongkai Wu Yingjun Wang Xuetao Shi | 2021 | Bioactive Materials2021，6，1： | 5 |
| 4 | Simulated annealing algorithm for the optimal translation sequence of the jth agent in rough communication显示文摘In rough communication, because each agent has a different language and cannot provide precise communication to each other, the concept translated among multi-agents will loss some information and this results in a less or rougher concept. With different translation sequences, the problem of information loss is varied. To get the translation sequence, in which the jth agent taking part in rough communication gets maximum information, a simulated annealing algorithm is used. Analysis and simulation of this algorithm demonstrate its effectiveness. | Wang Hongkai Guan Yanyong Xue Peijun | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 5 |
| 5 | Cuprizone-induced demyelination in mice: age-related vulner-ability and exploratory behavior deficit显示文摘Schizophrenia is a mental disease that mainly affects young individuals (15 to 35 years old) but its etiology remains largely undefined. Recently, accumulating evidence indicated that demyelination and/or dysfunction of oligodendrocytes is an important feature of its pathogenesis. We hypothesized that the vulnerability of young individuals to demyelination may contribute to the onset of schizophrenia. In the present study, three different age cohorts of mice, i.e. juvenile (3 weeks), young-adult (6 weeks) and middle-aged (8 months), were subjected to a 6-week diet containing 0.2% cuprizone (CPZ) to create an animal model of acute demyelination. Then, age-related vulnerability to CPZ-induced demyelination, behavioral outcomes, and myelination-related molecular biological changes were assessed. We demonstrated: (1) CPZ treatment led to more severe demyelination in juvenile and young-adult mice than in middle-aged mice in the corpus callosum, a region closely associated with the pathophysiology of schizophrenia; (2) the higher levels of demyelination in juvenile and young-adult mice were correlated with a greater reduction of myelin basic protein, more loss of CC-1-positive mature oligodendrocytes, and higher levels of astrocyte activation; and (3) CPZ treatment resulted in a more prominent exploratory behavior deficit in juvenile and young-adult mice than in middle-aged mice. Together, our data demonstrate an age-relatedvulnerability to demyelination with a concurrent behavioral deficit, providing supporting evidence for better understanding the susceptibility of the young to the onset of schizophrenia. | Hongkai Wang Chengren Li Hanzhi Wang Feng Mei Zhi Liu Hai-Ying Shen Lan Xiao | 2013 | Neuroscience Bulletin2013，29，2： | 4 |
| 6 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 7 | Rough communication of crisp concept in fuzzy approximation spaces显示文摘To study the problem of knowledge translation in fuzzy approximation spaces, the concept of rough communication of crisp set in fuzzy approximation spaces is proposed. In a rough communication of crisp set in fuzzy approximation spaces, the problem of uncertainty exists, for each agent has a different language and cannot provide precise communication to each other. By means of some concepts, such as CF rough communication cut, which is a bridge between fuzzy concept and crisp concept, cut analysis of CF rough communication is made, and the relation theorem between CF rough communication and rough communication of crisp concept is obtained. Finally, in order to give an intuitive analysis of the relation between CF rough communication and rough communication of crisp concept, an example is given. | Wang Hongkai Guan Yanyong Yu Zhaoxia | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 3 |
| 8 | Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression显示文摘Viral myocarditis(VMC)is a cardiac disease associated with myocardial inflammation and injury induced by virus infection.Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium.Kruppel-like factor 10(KLF10)is a crucial regulator of various pathological processes and plays different roles in a variety of diseases.However,its role in VMC induced by coxsackievirus B3(CVB3)infection remains unknown.In this study,we report that cardiac KLF10 confers enhanced protection against viral myocarditis.We found that KLF10 expression was downregulated upon CVB3 infection.KLF10 deficiency enhanced cardiac viral replication and aggravated VMC progress.Bone marrow chimera experiments indicated that KLF10 expression in nonhematopoietic cells was involved in the pathogenesis of VMC.We further identified MCP-1 as a novel target of KLF10 in cardiomyocytes,and KLF10 cooperated with histone deacetylase 1(HDAC1)to negatively regulate MCP-1 expression by binding its promoter,leading to activation of MCP-1 transcription and recruitment of Ly6C^(high) monocytes/macrophages into the myocardium.This novel mechanism of MCP-1 regulation by KLF10 might provide new insights into the pathogenesis of VMC and a potential therapeutic target for VMC. | Jie Yang Hongkai Zhang Xuelian Wang Jing Guo Lin Wei Yahui Song Yuan Luo YinXia Zhao Malayannan Subramaniam Thomas C.Spelsberg Lie Wang Wei Xu Min Li | 2021 | Cellular & Molecular Immunology2021，18，9： | 3 |
| 9 | Bract suppression regulated by the miR156/529-SPLs-NL1-PLA1 module is required for the transition from vegetative to reproductive branching in rice显示文摘Reproductive transition of grasses is characterized by switching the pattern of lateral branches,featuring the suppression of outgrowth of the subtending leaves(bracts)and rapid formation of higher-order branches in the inflorescence(panicle).However,the molecular mechanisms underlying such changes remain largely unknown.Here,we show that bract suppression is required for the reproductive branching in rice.We identified a pathway involving the intrinsic time ruler microRNAI56/529,their targets SQUAMOSA PROMOTER BINDING PROTEIN LIKE(SPL)genes,NECK LEAF1(NL1),and PLASTOCHRON1(PLA1),which regulates the bract outgrowth and thus affects the pattern switch between vegetative and reproductive branching.Suppression of the bract results in global reprogramming of transcriptome and chromatin accessibility following the reproductive transition,while these processes are largely dysregu-lated in the mutants of these genes.These discoveries contribute to our understanding of the dynamic plant architecture and provide novel insights for improving crop yields. | Lei Wang Luchang Ming Keyan Liao Chunjiao Xia Shengyuan Sun Yu Chang Hongkai Wang Debao Fu Conghao Xu Zhengji Wang Xu Li Weibo Xie Yidan Ouyang Qinglu Zhang Xianghua Li Qinghua Zhang Jinghua Xiao Qifa Zhang | 2021 | Molecular Plant2021，14，7： | 2 |
| 10 | Mechanical property of U-Shaped 65Mn steel bumpers for seismic base isolation显示文摘This study proposes a novel U-shaped 65Mn steel bumper as the displacement restraining device for base-isolated structures with laminated elastomeric rubber bearings.A series of bumpers with different geometric parameters were designed and tested under monotonic and cyclic quasi-static loading protocols.The experimental results from a total of 232 specimens were analyzed to develop an analytical model to calculate the backbone curve and the maximum elastic restoring force for U-shaped 65Mn bumpers.Thus,the analytical equations to calculate the elastic,hardening,and unloading stiffness of U-shaped 65Mn bumpers,as well as their maximum elastic restoring force,are validated by using an additional ten groups of bumpers with varying radiuses.These analytical equations can accurately predict the mechanical parameters of U-shaped 65Mn steel bumpers for a design purpose. | Han Miao Wang Yuandong Du Hongkai Cui Xiangdong | 2021 | Earthquake Engineering and Engineering Vibration2021，20，3： | 2 |
| 11 | Ecology of testate amoebae and their potential use as palaeohydrologic indicators from peatland in Sanjiang Plain, Northeast China显示文摘留有遗嘱的阿米巴是在 peatlands 的底层潮湿的敏感指示物。在最后十年,他们被学习了重建自从 Holocene,水文学变化。然而,这些研究地理上被限制了为北美洲和欧洲。我们在最大的大陆人上进行了留有遗嘱的阿米巴的第一调查在 Sanjiang 平原的新鲜的水沼泽地,中国。这研究的目的是在东北中国的 peatlands 在留有遗嘱的阿米巴的生态学上提供基线数据并且估计在这个生态系统把他们用作环境指示物的潜力。我们在 5 浸泡了水的消沉以内在 46 microsites 检验了现代留有遗嘱的变形虫集合和种类环境的关系。测量的环境参数包括了:深度将在点火上浇表格, pH,和损失。结果证明主导的种类是 Trinema complanatum 类型, Euglypha 圆形大厅类型, Euglypha strigosa 类型,和 Centropyxis 产於欧洲的黑醋栗类型。冗余性分析证明水表格深度在留有遗嘱的变形虫集合上有最重要的效果,解释 16.7%(p = 0.002 ) 全部的变化。pH 不是为留有遗嘱的变形虫集合的一个统计上重要的因素。加权的平均和加权的平均部分最少的广场模型被用来造转移功能让深度浇表格。最好表现的转移功能被加权的平均部分最少的广场模型与 r 产生 < 啜 class= “ a-plus-plus ” > 2 < 潜水艇 class= “ a-plus-plus ” > 0.62 的 LOSO 和 RMSEP < 潜水艇 class= “ a-plus-plus ” > 6.96 厘米的 LOSO 。结果显示在浸泡了水的消沉 peatland 的留有遗嘱的阿米巴有潜力在 Sanjiang 平原为水文学变化并且为 palaeohydrologic 重建被用作指示物。 | Lihong SONG Hongkai LI Kehong WANG Donghui WU Haitao WU | 2014 | Frontiers of Earth Science2014，8，4： | 2 |
| 12 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 13 | Set-valued information systems显示文摘 | Guan Yanyong Wang Hongkai | 2006 | Information Sciences2006，176，17： | 1 |
| 14 | Parameter regionalization of the FLEX-Global hydrological model显示文摘Global hydrological models(GHMs) are important tools for addressing worldwide change-related water resource problems from a global perspective. However, the development of these models has long been hindered by their low accuracy. In order to improve the streamflow simulation accuracy of GHMs, we developed a GHM—the FLEX-Global—based on the regionalization of hydrological model parameters. The FLEX-Global model is primarily based on the framework of the FLEX hydrological model coupled with the HAND-based Storage Capacity curve(HSC) runoff generation module to calculate net rainfall, and uses the global river-routing Ca Ma-Flood model to calculate river network routing. This new model allows for streamflow simulation at a spatial resolution of 0.5°×0.5° and a temporal resolution of 1 day in global catchments. To validate FLEX-Global accuracy, the FLEX-Global-simulated streamflow of 26 major rivers distributed in five different climate zones was compared with the observed data from the Global Runoff Data Center(GRDC). Next, the model performance of FLEXGlobal was further verified by comparing it with that of seven existing GHMs with varying accuracy in the five climate zones.Multi-metric evaluation indicated that the streamflow simulation accuracy was improved by the FLEX-Global model with regionalized parameters, especially in the tropical and dry climate zones. This newly-developed GHM with regionalized parameters can provide scientific support for the assessment of climate change impact, optimization of global water resource mangement, simulation of Earth's multi-sphere coupling, and implementation of the Inter-Sectoral Impact Model Intercomparison Project(ISIMIP). | Jingjing WANG Hongkai GAO Min LIU Yongjian DING Yan WANG Fang ZHAO Jun XIA | 2021 | Science China Earth Sciences2021，64，4： | 1 |
| 15 | Factors affecting appresorium formation of Magnaporthe grisea显示文摘M.grisea causes one of the major diseases on rice, rice blast. Appresorium formation is the key for the pathogen to penetrate into host tissue. | WANG Hongkai LIN Fucheng LI Debao Biotechnologv Inst,Zhe- jiang Univ Hangzhou 310029,China | 2001 | Chinese Rice Research Newsletter2001，9，4： | 1 |
| 16 | Robust incipient fault identification of aircraft engine rotor based on wavelet and fraction显示文摘 | Zhongsheng Wang Hongkai Jiang | 2010 | Aerospace Science and Technology2010，，4： | 1 |
| 17 | Set-valued intormation systems 显示文摘 | Guan Yanyong Wang Hongkai | 2006 | International Journal of Information Sciences2006，176，17： | 1 |
| 18 | Progress on deuterated potassium dihydrogen phosphate(DKDP)crystals for high power laser system application显示文摘In this review,we introduce the progress in the growth of large-aperture DKDP crystals and some aspects of crystal quality including determination of deuterium content,homogeneity of deuterium distribution,residual strains,nonlinear absorption,and laser-induced damage resistance for its application in high power laser system.Large-aperture high-quality DKDP crystal with deuteration level of 70%has been successfully grown by the traditional method,which can fabricate the large single-crystal optics with the size exceeding 400 mm.Neutron diffraction technique is an efficient method to research the deuterium content and 3D residual strains in single crystals.More efforts have been paid in the processes of purity of raw materials,continuous filtration technology,thermal annealing and laser conditioning for increasing the laser-induced damage threshold(LIDT)and these processes enable the currently grown crystals to meet the specifications of the laser system for inertial confinement fusion(ICF),although the laser damage mechanism and laser conditioning mechanism are still not well understood.The advancements on growth of large-aperture high-quality DKDP crystal would support the development of ICF in China. | Mingxia Xu Baoan Liu Lisong Zhang Hongkai Ren Qingtian Gu Xun Sun Shenglai Wang Xinguang Xu | 2022 | Light(Science & Applications)2022，11，9： | 1 |
| 19 | Bacterial-fungal interactions under agricultural settings:from physical to chemical interactions显示文摘Bacteria and fungi are dominant members of environmental microbiomes.Various bacterial-fungal interactions(BFIs)and their mutual regulation are important factors for ecosystem functioning and health.Such interactions can be highly dynamic,and often require spatiotemporally resolved assessments to understand the interplay which ranges from antagonism to mutualism.Many of these interactions are still poorly understood,especially in terms of the underlying chemical and molecular interplay,which is crucial for inter-kingdom communication and interference.BFIs are highly relevant under agricultural settings;they can be determinative for crop health.Advancing our knowledge related to mechanisms underpinning the interactions between bacteria and fungi will provide an extended basis for biological control of pests and pathogens in agriculture.Moreover,it will facilitate a better understanding of complex microbial community networks that commonly occur in nature.This will allow us to determine factors that are crucial for community assembly under different environmental conditions and pave the way for constructing synthetic communities for various biotechnological applications.Here,we summarize the current advances in the field of BFIs with an emphasis on agriculture. | Yaqi Zhou Hongkai Wang Sunde Xu Kai Liu Hao Qi Mengcen Wang Xiaoyulong Chen Gabriele Berg Zhonghua Ma Tomislav Cernava Yun Chen | 2022 | Stress Biology2022，2，1： | 1 |
| 20 | Set-valued information sys-tems显示文摘 | Guan Yangyong Wang Hongkai | 2006 | Information Sciences2006，176，17： | 1 |
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