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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 3 | Optimization of broadband omnidirectional antireflection coatings for solar cells显示文摘Broadband and omnidirectional antireflection coating is generally an effective way to improve solar cell efficiency, because the destructive interference between the reflected and incident light can maximize the light transmission into the absorption layer. In this paper, we report the incident quantum efficiency ηin, not incident energy or power, as the evaluation function by the ant colony algorithm optimization method, which is a swarm-based optimization method. Also, SPCTRL2 is proposed to be incorporated for accurate optimization because the solar irradiance on a receiver plane is dependent on position, season, and time. Cities of Quito, Beijing and Moscow are selected for two-and three-layer antireflective coating optimization over λ = [300,1100] nm and θ = [0°, 90°]. The ηin increases by 0.26%, 1.37% and 4.24% for the above 3 cities, respectively, compared with that calculated by other rigorous optimization algorithms methods, which is further verified by the effect of position and time dependent solar spectrum on the antireflective coating design. | Xia Guo Qiaoli Liu Huijun Tian Ben Li Hongyi Zhou Chong Li Anqi Hu Xiaoying He | 2019 | Journal of Semiconductors2019，40，3： | 4 |
| 4 | Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation,regulating Th17/Treg balance,maintaining intestinal barrier integrity,and modulating gut microbiota显示文摘Rabdosia serra(R.serra),an important component of Chinese herbal tea,has traditionally been used to treat hepatitis,jaundice,cholecystitis,and colitis.However,the chemical composition of R.serra and its effect against colitis remain unclear.In this study,the chemical composition of the water extract of R.serra was analyzed using ultra performance liquid chromatography coupled with a hybrid linear ion trap quadrupole-orbitrap mass spectrometer(UPLC-LTQ-Orbitrap-MS).A total of 46 compounds,comprising ent-kaurane diterpenoids,flavonoids,phenolic acids,and steroids,were identified in the water extract of R.serra,and the extract could significantly alleviate dextran sulfate sodium salt-induced colitis by improving colon length,upregulating anti-inflammatory factors,downregulating proinflammatory factors,and restoring the balance of T helper 17/T regulatory cells.R.serra also preserved intestinal barrier function by increasing the level of tight junction proteins(zonula occludens 1 and occludin)in mouse colonic tissue.In addition,R.serra modulated the gut microbiota composition by increasing bacterial richness and diversity,increasing the abundance of beneficial bacteria(Muribaculaceae,Bacteroides,Lactobacillus,and Prevotellaceae_UCG-001),and decreasing the abundance of pathogenic bacteria(Turicibacter,Eubacterium_fissicatena_group,and Eubacterium_xylanophilum_group).Gut microbiota depletion by antibiotics further confirmed that R.serra alleviated colitis in a microbiota-dependent manner.Overall,our findings provide chemical and biological evidence for the potential application of R.serra in the management of colitis. | Hongyi Li Yi Wang Shumin Shao Hui Yu Deqin Wang Chuyuan Li Qin Yuan Wen Liu Jiliang Cao Xiaojuan Wang Haibiao Guo Xu Wu Shengpeng Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 4 |
| 5 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 6 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 7 | Porous graphene paper for supercapacitor applications显示文摘Graphene paper shows a great promise for the electrical energy storage. However, the high stability, purity and specific surface area have become stringent requirements for supercapacitor applications. Finding methods to tackle these problems is rather challenging. Here, we develop a facile method to prepare porous graphene papers with a thickness 0.5 mm by a thermal shock to the layer-structure graphene paper self-assembled on Cu foil under nitrogen flowing. The as-prepared porous graphene paper exhibits a large specific capacitance of 100 F g^(-1)at the scan rate of 100 m V s^(-1)with high stability and purity without any residual chemical reagents, showing a promising potential for supercapacitor applications. The high electrochemical properties are mainly attributed to the high-specific area and the improved conductivity of the porous graphene paper performed by the multieffect of reducing, cleaving and expanding to the layer-structure graphene paper by high-energy thermal heating during the thermal shock process. This work paves a pathway to the facile preparation of porous graphene paper for supercapacitor applications. | Qi Li Xinli Guo Yao Zhang Weijie Zhang Chuang Ge Li Zhao Xiaojuan Wang Hongyi Zhang Jian Chen Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，8： | 2 |
| 8 | Use of electrosense in the feeding behavior of sturgeons显示文摘The electro-receptive lateral line system appeared early in the evolutionary history of fish.Sturgeons,members of the primitive Chondrostei group,are known for their electroreceptors(ampullae of Lorenzini)on the head,which are thought to be sensitive to weak electric fields in aquatic environments and involved in feeding,mating and migration.Here,we report the results of a set of behavioral and electrophysiological experiments designed to determine the function and characteristics of the electrosense in cultured sturgeons.The results showed Sibe-rian sturgeon(Acipenser baerii Brandt,1869)feeding striking at bio-electric fields produced by living feed-fish enclosed in a gel chamber and at the corrosion field produced by metal rods.With an electric stimulus that mim-ics the bio-electric fields produced by living prey,the relative discharge rate of electrosensory neurons in the dorsal octavolateralis nucleus(DON)was modulated by and phase-locked to sinusoidal stimulus and some units showed selectivity for dipolar direction in white sturgeon(Acipenser transmontanus Richardson,1836).This is the first study to provide the empirical evidence correlating with electrosensory behaviors and electrophysiolog-ical responses in cultured sturgeons,and suggesting that electrosense does play an innate role in feeding behav-ior of sturgeon.We believe this will have important implications for protecting sturgeons in the wild. | Xuguang ZHANG Jiakun SONG Chunxin FAN Hongyi GUO Xiaojie WANG Horst BLECKMANN | 2012 | Integrative Zoology2012，7，1： | 2 |
| 9 | Au nanoparticles decorated graphene/nickel foam nanocomposite for sensitive detection of hydrogen peroxide显示文摘The Au nanoparticles decorated graphene(AuNPs@Gr)/nickel foam(Gr/NiF) nanocomposite(AuNPs@Gr/NiF) was prepared by chemical vapor deposition followed by electrophoretic deposition of AuNPs on Gr/NiF. The morphology, microstructure and sensing performance of the as-prepared AuNPs@Gr/NiF nanocomposite were characterized and measured, respectively by scanning electron microscope, transmission electron microscope, ultraviolet visible spectroscopy and chemical workstation. The asprepared AuNPs@Gr/NiF nanocomposite was used as the electrode to construct a chemical sensor for the detection of hydrogen peroxide(H_2O_2). The results showed that the AuNPs distributed homogenously and stably on the surface of Gr/NiF. The chemical sensor exhibits a sensitive and selective performance to the detection of H_2O_2. | Xiaojuan Wang Xinli Guo Jian Chen Chuang Ge Hongyi Zhang Yuanyuan Liu Li Zhao Yao Zhang Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 10 | Preliminary results of Sr∶Ca ratios of Coilia nasus in otoliths by micro PIXE显示文摘 | ZHONG Ling GUO Hongyi SHEN Hao | 2007 | Nuclear Instruments and Methods in Physics Research2007，260，1： | 1 |
| 11 | Annual Operation Status of SECRAL in 2009显示文摘 | Lu Wang Sun Liangting Feng Yucheng Guo Xiaohong Zhang Xuezheng Li Jingyu Cao Yun Wang Hui Ma Baohua Shang Yong Sha Shan Ma Hongyi Li Xixia Lin Shuhao Zhang Wenhui Jin Tao Zhao Huanyu Zhao Hongwei | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 12 | Operation of LECR3显示文摘 | Feng Yueheng Ma Baohua Wang Hui Li Jinyu Cao Yun Shang Yong Lu Wang Sha Shan Ma Hongyi Zhang Wenhui Lin Shuhao Li Xixia Zhao Huanyu Miao Tingting Guo Xiaohong Zhang Xuezhen Sun Liangting | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 13 | Experimental Study on Friction Coefficient Between Concrete and the Top Surface of Rubble Mound Foundation显示文摘 | Li Yanbao Jiang Xuedong Guo Hongyi | 2005 | China Ocean Enginnering2005，19，2： | 1 |
| 14 | Performance analysis of physical-layer network coding based on MAP mapping algorithm显示文摘 | Lu Ling Yu Hongyi Guo Jinhuai | 2007 | Journal of Xidian University (Natural science)2007，，： | 1 |
| 15 | Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population显示文摘Objective:Hereditary colorectal cancer(CRC)accounts for approximately 5%–10%of all CRC cases.The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.Methods:We performed the first population study investigating the germline mutation status in more than 1,000(n=1,923)Chinese patients with CRC and examined their relationship with the somatic mutational landscape.Germline alterations were examined with a 58-gene next-generation sequencing panel,and somatic alterations were examined with a 605-gene panel.Results:A total of 92 pathogenic(P)mutations were identified in 85 patients,and 81 likely pathogenic(LP)germline mutations were identified in 62 patients,accounting for 7.6%(147/1,923)of all patients.MSH2 and APC was the most mutated gene in the Lynch syndrome and non-Lynch syndrome groups,respectively.Patients with P/LP mutations had a significantly higher ratio of microsatellite instability,highly deficient mismatch repair,family history of CRC,and lower age.The somatic mutational landscape revealed a significantly higher mutational frequency in the P group and a trend toward higher copy number variations in the non-P group.The Lynch syndrome group had a significantly higher mutational frequency and tumor mutational burden than the nonLynch syndrome group.Clustering analysis revealed that the Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Population risk analysis indicated that the overall odds ratio was 11.13(95%CI:8.289–15.44)for the P group and 20.68(95%CI:12.89–33.18)for the LP group.Conclusions:Distinct features were revealed in Chinese patients with CRC with germline mutations.The Notch signaling pathway was uniquely clustered in the Lynch syndrome group,and the MAPK and cAMP signaling pathways were uniquely clustered in the non-Lynch syndrome group.Patients with P/LP germline mutations exhibited higher CRC risk. | Jianfei Yao Yunhuan Zhen Jing Fan Yuan Gong Yumeng Ye Shaohua Guo Hongyi Liu Xiaoyun Li Guosheng Li Pan Yang Xiaohui Wang Danni Liu Tanxiao Huang Huiya Cao Peisu Suo Yuemin Li Jingbo Yu Lele Song | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 16 | Parallel machines earliness and tardiness scheduling with proportional weights显示文摘 | SUN Hongyi GUO Qing | 2003 | Computers Operation Research2003，30，5： | 1 |
| 17 | An Entity-Association-Based Matrix Factorization Recommendation Algorithm显示文摘Collaborative filtering is the most popular approach when building recommender systems,but the large scale and sparse data of the user-item matrix seriously affect the recommendation results.Recent research shows the user’s social relations information can improve the quality of recommendation.However,most of the current social recommendation algorithms only consider the user's direct social relations,while ignoring potential users’interest preference and group clustering information.Moreover,project attribute is also important in item rating.We propose a recommendation algorithm which using matrix factorization technology to fuse user information and project information together.We first detect the community structure using overlapping community discovery algorithm,and mine the clustering information of user interest preference by a fuzzy clustering algorithm based on the project category information.On the other hand,we use project-category attribution matrix and user-project score matrix to get project comprehensive similarity and compute project feature matrix based on Entity Relation Decomposition.Fusing the user clustering information and project information together,we get Entity-Association-based Matrix Factorization(EAMF)model which can be used to predict user ratings.The proposed algorithm is compared with other algorithms on the Yelp dataset.Experimental studies show that the proposed algorithm leads to a substantial increase in recommendation accuracy on Yelp data set. | Gongshen Liu Kui Meng Jiachen Ding Jan P.Nees Hongyi Guo Xuewen Zhang | 2019 | Computers, Materials & Continua2019，，1： | 1 |
| 18 | Parallel machine earliness and tardiness scheduling with proportional weights 显示文摘 | Sun Hongyi Guo qing | 2003 | Computers & Operations Research2003，，30： | 1 |
| 19 | Sound production in marbled rockfish (Sebastiscus marmoratus) and implications for fisheries显示文摘Recently,several rockfish species(genus Sebastes)have been reported to be soniferous.To determine whether an additional rockfish species produces sounds,passive acoustic recordings were analyzed from captive marbled rockfish(Sebastiscus marmoratus)during the non-spawning season.Three distinct sounds were identified based on frequency features.The common characteristics among all sounds were low frequency(below 300 Hz)and rapidly dampened pulses consisting of 3–5 acoustic energy cycles.During free-swimming conditions in the canvas tank,the fish produced voluntary sounds with lower frequencies than the disturbance sounds produced by individuals during prodding.Two types of sounds were identified in the disturbance context:one type consists of single or double pulses with two peak frequencies,and another type consists of a series of pulses with a single peak frequency.These results suggest that specific-species and behavior-associated sounds are potentially useful in passive acoustical surveys to monitor rockfish populations and distributions remotely. | Xuguang ZHANG Hongyi GUO Shouyu ZHANG Jiakun SONG | 2015 | Integrative Zoology2015，10，1： | 1 |
| 20 | 6 - 18 Operation Status of On-line Ion Sources in 2012显示文摘 | FengYucheng Lu Wang Li Jinyu Zhang Wenhui Ma Hongyi Ma Baohua Wang Hui Li Jiaqing Lin Shuhao Cao Yun Sha Shan W u Qi Guo Junwei Fang Xing Yang Yao Li Xixia Zhang Hengjuan Zhao Huanyu Zhang Xuezhen Sun Liangting Zhao Hongwei | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
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