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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 3 | Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic reviewofrandomized controlled trials显示文摘 | Lisa Rambout BSc Phm Laura Hopkins MD MSC Brian HuHon MSC Dean Fergusson PhD | 2007 | CMAJ2007，17，5： | 1 |
| 4 | The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib,nilotinib and dasatinib显示文摘 | Deadman B J Hopkin MD Ley SV | 2013 | Org Biomol Chem2013，11，11： | 1 |
| 5 | Hemangioma of the vertical segment of the facial nerve显示文摘 | Hopkins B Aygun N Eisen MD | 2007 | Otol Neurotol2007，28，4： | 1 |
| 6 | Modeling and simulation of ion channels and action potentials in taste receptor cells显示文摘Based on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their corresponding ionic components, including voltage-gated Na+ currents and outward delayed rectifier K+ currents. Our simulations reproduced the action potentials of taste receptor cells in response to electrical stimuli or sour tastants. The kinetics of ion channels and their roles in action potentials of taste receptor cells were also analyzed. Our prototype model of single taste receptor cell and simulation results presented in this paper provide the basis for the further study of taste information processing in the gustatory system. | CHEN PeiHua1, LIU Xiao-dong2, ZHANG Wei1, ZHOU Jun1, WANG Ping1, YANG Wei3 & LUO JianHong3 1Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China 2Calcium Signals Lab, Department of Biomedical Engineering and Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA 3Department of Neurobiology, Institute for Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China | 2009 | Science China(Life Sciences)2009，52，11： | 1 |
| 7 | Identification of virulence genes in uropathogenic Escherichia coli by multiplex polymerase chain reaction and their association with infectivity in mice显示文摘 | Morin MD Hopkins WJ | 2002 | Urology2002，60，3： | 1 |
| 8 | A flow-based synthesis of imatinib: the API of Gleevec 显示文摘 | Hopkin MD Baxendale IR Ley SV | 2010 | Chem Commun2010，46，： | 1 |
| 9 | Transient and sustained changes in myofilament sensitivity to Ca^2 + contribute to the inotropic effects of sevoflurane in rat ventricle 显示文摘 | Graham MD Bru-Mercier G Hopkins PM | 2005 | Br J Anaesth2005，94，3： | 1 |
| 10 | Transient and sustained changes in myofilament sensitivity to Ca^2+ contribute to the inotropic effects sevoflurane in rat ventricle 显示文摘 | Graham MD Bru-Mercier G Hopkins PM | 2005 | Br J Anaesth2005，94，3： | 1 |
| 11 | Hemangioma of the Vertical Segment of the Facial Nerve显示文摘 | Hopkins B Aygun N Eisen MD | 2007 | Otol Neurotol2007，28，40： | 1 |
| 12 | Hemangioma of the vertical segment of the facial nerve显示文摘 | Hopkins B Aygun N Eisen MD | 2007 | Otol Neurot012007，28，40： | 1 |
| 13 | Major histocompatibility complex class I cytotoxic T lymphocyte immunity to human metapneumovirus(hMPV)in individuals with previous hMPV infection and respiratory disease显示文摘 | Herd KA Nissen MD Hopkins PM | 2008 | J Infect Dis2008，197，： | 1 |
| 14 | Antagonistic actions of halothane and sevoflurane on spontaneous Ca^2+ release in rat ventricular myocytes显示文摘 | Graham MD Hopkins PM Harrison SM | 2006 | Anesthesiology2006，105，1： | 1 |
| 15 | The Degree of Symmetry of Certain Compact Smooth Manifolds II显示文摘We give the sharp estimates for the degree of symmetry and the semi-simple degree of symmetry of certain compact fiber bundles with non-trivial four dimensional fibers in the sense of cobordism, by virtue of the rigidity theorem of harmonic maps due to Schoen and Yau (Topology, 18, 1979, 361-380). As a corollary of this estimate, we compute the degree of symmetry and the semi-simple degree of symmetry of CP2×V, where V is a closed smooth manifold admitting a real analytic Riemannian metric of non-positive curvature. In addition, by the Albanese map, we obtain the sharp estimate of the degree of symmetry of a compact smooth manifold with some restrictions on its one dimensional cohomology. | Bin XU Department of Mathematics, University of Science and Technology of China, Hefei 230026, China Chern Institute of Mathematics, Nankai University, Tianjin 300071, China Department of Mathematics, Johns Hopkins University, Baltimore, MD 21218, USA. | 2007 | Chinese Annals of Mathematics,Series B2007，28，2： | 0 |
| 16 | PROBING THE EARLY UNIVERSE WITH DEEP OBSERVATIONS AND LARGE SURVEYS显示文摘Recent advances in astronomy have enabled scientists to reach the early universe to an unprecedented depth. With the new telescopes such as the Chandra, FUSE, and with the Sloan Digital Sky Survey (SDSS), we have gained critical insights into the 'Origin of our Universe', i.e. how the intergalactic medium evolves to form galaxies and quasars. SDSS has broken a ten-year barrier of z=5 to reach the very early universe, with the discovery of five quasars at z 5.0. The survey will find more than ten thousands of quasars, enabling us to carry out the most comprehensive classification of quasars. FUSE finds traces of the primordial matter at z ~3, which corresponds to hydrogen column density as low as 10 -11 cm -2 and cannot be detected even with the largest optical telescope. The finding suggests that the intergalactic medium is an evolving and complex entity, and it is ionized mainly by the accumulated radiation from quasars. The Chandra telescope has taken a million second deep exposure of a selected region, reaching about twenty times deeper than ROSAT to a limiting flux of 5 × 10 -17 ergs s -1 cm -2 in the 0.5-2 keV band. The sources found so far can account for up to 90% of the hard X-ray background field, and they consist of Seyfert-2 and normal galaxies at z < 1 and quasars at z < 4.5. In the near future, the Next Generation Space Telescope and others will reveal the first generation of baryonic objects after the Big Bang. | Zheng Wei (Department of Physics and Astronomy, The Johns Hopkins University Baltimore, MD 21218-2686, USA) (Center for Astrophysics University of Science and Technology of China, Hefei, AnHui, 230026) | 2001 | 中国科学院上海天文台年刊2001，，1： | 0 |
| 17 | Parameterization of the Non-Local Thermodynamic Equilibrium Source Function with Chemical Production by an Equivalent Two-Level Model显示文摘The classic two-level or equivalent two-level model that includes only the statistical equilibriumof radiative and thermal processes of excitation and quenching between two vibrational energy levelsis extended by adding chemical production to the rate equations. The modifications to the non-localthermodynamic equilibrium source function and cooling rate are parameterized by φc, which characterizesthe ratio of chemical production to collisional quenching. For applications of broadband emission of O3 at9.6 μm, the non-LTE effect of chemical production on the cooling rate and limb emission is proportionalto the ratio of O to O3. For a typical [O]/[O3], the maximum enhancements of limb radiance and coolingrate are about 15%-30% and 0.03-0.05 K day-1, respectively, both occurring near the mesopause regions.This suggests that the broadband limb radiance above ~80 km is sensitive to O3 density but not sensitiveto the direct cooling rate along the line-of-sight, which makes O3 retrieval feasible but the direct coolingrate retrieval difficult by using the O3 9.6 μm band limb emission. | Xun ZHUThe Johns Hopkins University Applied Physics Laboratory, MD 20723-6099, USA | 2003 | Advances in Atmospheric Sciences2003，20，4： | 0 |
| 18 | Recent Development of OCT Technologies显示文摘Optical coherence tomography (OCT) was first reported about 18 years ago. OCT was originally developed for imaging the relatively transparent eye tissue, and later applied | Xingde Li Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205 | 2009 | 生物物理学报2009，25，S1： | 0 |
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