|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnostic value of antigenemia assay for cytomegalovirus gastrointestinal disease in immunocompromised patients显示文摘AIM:To investigate the utility of the cytomegalovirus(CMV)antigenemia assay for the diagnosis of CMV gastrointestinal disease(GID). METHODS:One hundred and thirty immunocompromised patients were enrolled in this study.Patients with a history of anti-CMV treatment and who had not undergone examination using the antigenemia assay were excluded.CMV-GID was defined as the detection of large cells with intranuclear inclusions alone or associated with granular cytoplasmic inclusions by biopsy.Biopsy sections were stained with hematoxylin and eosin and immunohistochemically stained with anti-CMV.We evaluated the association between CMV-GID and patient characteristics(symptoms,underlying disease,medication,leukocyte counts,and antigenemia assay).All patients were checked with an human immunodeficiency virus(HIV)antibody test before endoscopic examination.White blood cell(WBC)counts were obtained from medical records within 1 wk of endoscopy.Leukopenia was defined as a total WBC count<5000 cells/mm 3 . For HIV patients,we also checked CD4+counts from medical records. RESULTS:A total of 99 patients were retrospectively selected for analysis.Of the immunocompromised patients,19 had malignant disease,18 had autoimmune disease,19 had disorders of biochemical homeostasis, three had undergone transplantation,and 45 had HIV infection.A total of 50 patients had received immunosuppressive therapy.No patients had inflammatory bowel disease.Fifty-five patients were diagnosed as having CMV-GID.Univariate analysis indicated an association between HIV infection,leukopenia,and positive antigenemia and CMV-GID(P<0.05).Multivariate analysis using logistic regression revealed that HIV infection and positive antigenemia were the only independent factors related to CMV-GID(P<0.01).The sensitivity,specificity,positive predictive value,and negative predictive value of antigenemia for CMV-GID were 65.4%,93.6%, 91.9%,and 71.0%,respectively.In a subgroup analy-sis,patients with leukopenia displayed low sensitivity and high specificity.Minimal differences in accuracy were seen among patients with or without leukopenia. HIV-infected patients displayed low sensitivity and high specificity.Accuracy barely differed between HIV-positive and-negative patients.In HIV-infected patients, CD4 count<50 cells/μL resulted in low sensitivity and high specificity.Differences in accuracy among patients were minor,regardless of CD4 count.In patients who had undergone both quantitative real-time polymerase chain reaction(PCR)and antigenemia assay,real-time PCR was slightly more accurate in terms of sensitivity than the antigenemia assay;however,this difference was not statistically significant(P=0.312). CONCLUSION:If the antigenemia test is positive,endoscopic lesions are acceptable for the diagnosis of CMVGID without biopsy.The accuracy is not affected by HIV infection and leukopenia.Either PCR or the antigenemia assay are valid. | Naoyoshi Nagata Masao Kobayakawa Takuro Shimbo Kazufusa Hoshimoto Tomoyuki Yada Takuji Gotoda Junichi Akiyama Shinichi Oka Naomi Uemura | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 2 | Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases显示文摘AIM:To evaluate prospectively usefulness of fecal lactoferrin(Lf)and fecal hemoglobin(Hb)in the diagnosis of colorectal diseases.METHODS:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal endoscopy.RESULTS:Lf was positive in 18(50%)of 36 patients with colorectal cancer,25(15.9%)of 157 with colorectal polyps,29(46.8%)of 62 with ulcerative colitis,and 25(62.5%)of 40(62.5%)with Crohn's disease.The Hb-positive rates were 50%,12.1%,41.9% and 32.5%,respectively.Of the 318 patients free of abnormalities by colorectal endoscopy,Lf was positive in 29(9.1%)and Hb was positive in 15(4.7%).Among patients with Crohn's disease,the Lf-positive rate was significantly higher than the Hb-positive rate.If either high Lf or Hb levels were considered positive,the positive rates rose to 61.1%,51.6%,and 67.5% in the colorectal cancer group,ulcerative colitis group,and Crohn's disease group,respectively.If both high Lf and Hb levels were rated positive,the positive predictive values(PPV)were 21% for colorectal cancer,33% for ulcerative colitis,and 17% for Crohn's disease,and PPV of high Hb level alone was 18%,25% and 13%,respectively.CONCLUSION:Fecal Lf and Hb were found useful in the detection of colorectal diseases,and the combination of the two measurements appears to increase the sensitivity and efficacy of diagnosis. | Ichiro Hirata Masahiro Hoshimoto Osamu Saito Masanobu Kayazawa Takashi Nishikawa Mitsuyuki Murano Ken Toshina Fang-Yu Wang Ryoichi Matsuse | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 3 | Anaplastic carcinoma of the pancreas: Case report and literature review of reported cases in Japan显示文摘We report a case of a 64-year-old woman with anaplastic carcinoma of the pancreas(ACP) with cyst formation and review 60 ACP cases reported in Japan. In 20% of cases, laboratory tests revealed severe anemia(hemoglobin level < 10.0 g/d L) and elevated leucocyte counts(> 12000/mm3), which were likely attributable to rapid tumor growth, intratumoral hemorrhage, and necrosis. Elevated serum CA19-9 levels were observed in 55% of cases. Cyst-like structures were observed on imaging in 47% of cases, and this finding appears to reflect subsequent cystic degeneration in the lesion. Macroscopically, hemorrhagic necrosis was observed in 77% of cases, and cyst formation was observed in 33% of cases. ACP should be considered when diagnosing pancreatic tumors with a cyst-like appearance, especially in the presence of severe anemia, elevated leucocyte counts, or elevated serum CA19-9 levels. | Sojun Hoshimoto Junichi Matsui Ryohei Miyata Yutaka Takigawa Jun Miyauchi | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Increased levels of macrophage colony-stimulating factor in the placenta and blood in preeclampsia 显示文摘 | Hayashi M Hoshimoto K Ohkura T | 2002 | Am J Reprod Immunol2002，47，1： | 1 |
| 5 | CD44variant 6 in endometrioid carcinoma of the uterus : Its expression in the adenocarcinoma component is an independent prognostic marker 显示文摘 | Hoshimoto K Yamauchi N Takazawa Y | 2003 | Pathol Res Pract2003，199，2： | 1 |
| 6 | CD44 variant 6 in Endometrioid carcinoma of the uterus: Its expression in the adenocarcinoma componentis an independent prognostic marker显示文摘 | Hoshimoto K Yamauchi N TakazawaY | 2003 | Pathol Res Pract2003，199，2： | 1 |
| 7 | Changes in urinary excretion of six biochemical parameters in normotensive pregnancy and preeclampsla 显示文摘 | Hayashi M ueda Y hoshimoto K | 2002 | Am J kidey Dis2002，39，2： | 1 |
| 8 | Successful conception following fallopian tabe recanalization in interfile patientswith a unilateral proximally occluded tube andw contra lateralpatent tube显示文摘 | Hayashpim Hoshimoto K Ohkara T | 2003 | Hum Reprot2003，18，1： | 1 |
| 9 | Reasults of mic tosurgical treatment for intramedul lary spinal cord ependymomas: analysis of 36 cases显示文摘 | Hoshimaru M Koyawa T Hoshimoto N | 1999 | Neurosurgery1999，44，2： | 1 |
| 10 | Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma显示文摘 | Hayashi M Tomobe K Hoshimoto K | 2002 | Int J Clin Pract2002，56，2： | 1 |
| 11 | CD44 variant 6 inendometrioid carcinoma of the uterus:its expression in the adeno-carcinoma component is an independent prognostic marker显示文摘 | Hoshimoto K Yamauchi N Takazawa Y | 2003 | Pathol Res Pract2003，199，2： | 1 |
| 12 | Hepatocellular carcinoma with extensive peliotic change显示文摘 | Sojun Hoshimoto Zenichi Morise Keiichi Suzuki Yoshinao Tanahashi Masahiro Ikeda Tadashi Kagawa Yoshizumi Mizoguchi Atsushi Sugioka | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 1 |
| 13 | CD44 variant 6 in endometrioid carcinoma of the uterus: Its expression in the adenocarcinoma component is an independent prognostic marker显示文摘 | Hoshimoto K Yamauchi N Takazawa Y | 2003 | Pathol Res Pract2003，199，2： | 1 |
| 14 | Changes in urinary ex- cretion of six biochemical parameters in normotensive pregnancy and preeclampsia显示文摘 | Hayashi M Ueda Y Hoshimoto K | 2002 | Am J Kidney Dis2002，39，2： | 1 |
| 15 | Macrophage colony-stimulating factor levels in amniotic fluid before and after the onset of labor do not differ in normal pregnancies显示文摘 | Hayash M Hoshimoto K Komine F | 2004 | Am J Reprod Immunol2004，51，5： | 1 |
| 16 | Results of microsurgical treatment for intramedullary spinal cord ependymomas:analysis of 36 cases显示文摘 | Hoshimaru M Koyama T Hoshimoto N | 1999 | Neurosurgery1999，44，： | 1 |
| 17 | Results ofmicrosurgical treatment for intramedullary spinal cord ependymomas: analysis of 36 cases 显示文摘 | Hoshimaru M Koyama T Hoshimoto N | 1999 | Neurosurgery1999，44，： | 1 |
| 18 | Characterization of five marker levels of the hemostatie system and endothelial status in normotensive pregnancy and pre-eclampsia 显示文摘 | Hayashi M Inoue T Hoshimoto K | 2002 | Eur J Haematol2002，69，： | 1 |
| 19 | Results of microsurgical treatment for intramedullary spinal cord ependymomas:analysis of 36 cases显示文摘 | Hoshimaru M Koyawa T Hoshimoto N | 1999 | Neurosurgery1999，44，2： | 1 |
| 20 | Increased levels of macrophage colony - stimulating factor in the placenta and blood in preeclampsia 显示文摘 | Hayashi M Hoshimoto K Ohkura T | 2002 | Am J Reprod Immunol2002，47，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员